The strategic cost management of the hospital means setting the cost management of the hospital in the realm of strategic management and analyzing the hospital and its cost behavior and structure from a strategic level so as to create advantages in competition, attain the goal of adapting the hospital to the continuously changing environment and facilitating stralegic management. Strategic cost management is characterized by a protracted, overaU, extensional and innovative nature and methods for it include value chain analysis, strategic positioning analysis, cost agent analysis and many others. Clarifying the goals of strategic cost management, selecting different strategies according to strategic cost information, perfecting the cost management of the hospital and enhancing cost awareness, and giving play to the functional role of economic management personnel are some of the prerequisites for the hospital to implement strategic cost management.

Objective To explore the method of repairing foot soft tissue defects by using island skin flaps pedicled with sural nerves and vessels. Methods 24 patients with foot soft tissue defects were treated surgically. The defects were repaired with island skin flaps pedicled with ipsilateral sural nerves and vessels. Results Of all the 24 flaps, 21 flaps survived at the first intention. Partial necrosis appeared in 3 flaps but were cured at the second intention. The follow ups of 1 to 2 years showed that the appearance and function were satisfactory in all the cases except 4 in which the skin appeared swollen. Conclusion To repair foot soft tissue defects, this flap has the advantages of strong anti infection ability and good texture so that healing at the first intention and early functional recovery can be obtained.

Stem cell transplantation provides a new thinking for treating ischemic heart disease.However,the poor survival and differentiation rate of stem cells after transplantation limit its application in treatment of ischemic heart disease.Therefore,researchers study precondition stem cells through different methods to improve stem cell proper- ty in order to improve therapeutic effect of stem cell transplantation.The present article made a review on its re- search progress.

SOX1,a member of the SOX transcript factor super family,has been demonstrated having the functions of regulating the development of human embryonic neural system and crystalline lens,and the additional function of SOX1 in tumors are attracting more and more attention as well.It is reported in resent years that SOX1 is detected lowly expressed in many kinds of tumor issues,which owns to the methylation of SOX1.SOX1 can also regulate the abilities of tumors on proliferation,invasion and migration.Besides,SOX1 may play a crucial role in regulation of the differentiation of cancer stem cells.Further research of SOX1 and its function among related pathways may contribute to seeking for new therapies for tumor treatment.

Objective To observe the effects of Haizao Yuhu Decoction on the CXCR 4 expression of TT cell tumor-bearing mice. Methods Culture the human thyroid TT cells in vitro, and inoculate them into 30 healthy mice BALB/C. Subsequently, Haizao Yuhu Decoction was given to the tumor-bearing mice. They are grouped into three groups, including tumor-bearing group (n=10), Haizao Yuhu Decoction high dosage group (n=10) and Haizao Yuhu Decoction low dosage group (n=10) to observe the tumor growth to calculate the anti-tumor rate. After the tumor has been reaped, immunohistochemical is adopted to test the expressions of chemotactic factor receptor-CXCR 4 on protein level. RT-PCR is used to test the expressions of CXCR 4 on genetic level. Results Comparing with the tumor-bearing group, HZYHD high-dosage group has decreased the expressions of CXCR 4 on both the protein and genetic levels, which is to certain degree dependent on concentration.Conclusion Haizao Yuhu Decoction could decrease the expression of CXCR 4.

Gastrointestinal microbiota is a huge and complex system that has multiple influential factors. As an exogenous pathogen,Helicobacter pylori(Hp)may interact with gastrointestinal microbiota. It has been revealed that Hp infection led to an increase in Lactobacillus acidophilus in intestinal tract and a decrease in Actinobacteria,Bacteroidetes and Firmacutes in stomach. Proton pump inhibitors and antibiotics,the major components of eradication regimens for Hp infection,may also have an impact on gastrointestinal microbiota. On the other hand,gastrointestinal microbiota interferes with Hp’s attachment into gastric mucosa. Probiotics combined with eradication therapy could benefit the eradication rate of Hp infection and reduce adverse events.

Objective To evaluate the efficacy and safety of adjuvant IFN therapy for viral hepatitis-related hepatocellular carcinoma(HCC)after treatment with surgical resection or transarterial chemoembolization(TACE).Methods Controlled trials of adjuvant treatment with IFN for patients with HCC published between 2000 and 2012 were searched electronically in MEDLINE,PubMed,Cochrane Library,and EMBASE databases.According to the heterogeneity of the studies,two different models-the fixed-effect model and the random-effect model-were applied to analyze the results. Results Ten trials were screened according to inclusion and exclusion standards.Eight randomized,controlled trials and two non-randomized,controlled trials were included.These ten trials with a total of 1 ,029 subjects were eventually involved in the meta-analysis;528 HCC patients were treated with adjuvant treatment with IFN and 501 patients with placebo.Compared to the control group,the recurrence rates of HCC in IFN group were significantly lower CR=0.66;95% CI=0.50 to 0.86;P=0.02),especially after TACE treatment according to subgroup analysis(OR=0.73;95%CI=0.52 to 1.01;P=0.06 for surgical resection;and OR=0.54;95%CI=0.33 to 0.86,P=0.01 for TACE).The death rates in the IFN group also significantly decreased according to not only total events analysis(OR=0.42;95%CI=0.32 to 0.56;P<0.01)but also subgroup analysis(OR=0.51;95%CI=0.36 to 0.72;P=0.0002 for surgical resection;and OR=0.33;95%CI=0.21 to 0.50;P<0.01 for TACE).Conclusion Adjuvant IFN therapy may significantly reduce the recurrence rates of patients with viral hepatitis-related HCC and improve the survival of patients after surgical resection or TACE.The ideal dose mostly selected is 3 MIU/mL,three times per week,which can make patients tolerate the adverse reactions of IFN better and maintain effective concentrations for a long time.

Interleukin-24 (IL-24) is a novel cancer suppressor cytokine. It can suppress cancer cell growth, induce cancer cell apoptosis, inhibit angiogenesis, stimulate the PBMC secretion of cytokines, and enhance the antitumor activity of radiotherapy, chemotherapy and targeting gene-virotherapy. It is reasonable to suggest that IL-24 may be a powerful and effective protocol for combinatorial cancer treatment in the clinic.

OBJECTIVETo explore the impact on neutrophil-to-lymphocyte ratio (NLR) and the quality of life (QOL) in the patients of non-small-cell lung cancer (NSCLC) treated with wheat-size moxibustion therapy.

METHODSSeventy patients of NSCLC were randomized into an observation group and a control group, 35 cases in each one. Finally, 33 cases were participated in the observation group and 32 cases in the control group for statistical analysis. In the observation group, Zusanli (ST 36) and Feishu (BL 13) were selected for grain-size moxibustion, 9 moxa cones on each acupoint, once a day. There was the follow-up visit without any treatment applied in the control group. The trial lasted for 6 weeks. The changes in NLR and the QOL score before and after treatment were observed in the patients of the two groups and the differences were compared between the two groups.

RESULTSCompared with the condition before treatment, in the observation group, NLR was reduced apparently (P< 0.05), the general health state/life quality field, physical functioning, emotional functioning, cognitive functioning, fatigue, pain, short breath, insomnia and anorexia were improved apparently (all P < 0.05). In the control group, the differences were not significant in NLR, the general health states/life quality field, physical functioning, emotional functioning, cognitive functioning, role functioning, social functioning, fatigue, pain, short breath, insomnia and anorexia before and after treatment (all P > 0.05). In comparison of the two groups, NLR was reduced apparently in the observation group as compared with that in the control group after treatment (P < 0.05). The scores of the general health state/life quality field, physical functioning, emotional functioning and cognitive functioning were increased apparently as compared with those in the control group after treatment (all P < 0.05). The scores of fatigue, pain, short breath, insomnia and anorexia in the observation group were reduced apparently as compared with those in the control group after treatment (all P < 0.05).

CONCLUSIONThe wheat-size moxibustion therapy reduces NLR and improves the immune function and quality of life in the patients of NSCLC.

Adult ; Aged ; Carcinoma, Non-Small-Cell Lung ; immunology ; therapy ; Female ; Humans ; Lung Neoplasms ; immunology ; therapy ; Lymphocytes ; immunology ; Male ; Middle Aged ; Moxibustion ; Neutrophils ; immunology ; Quality of Life

High-resolution melting technique shows great potential as a clinical diagnostic tool because of its cost-effectiveness , convenience and closed-tube format which can prevent the risk of cross contamination.HRM analysis has been widely used in molecular diagnostics in the management of cancer by mutation detection , pre-sequence screening , methylation and copy number variations , which involves cancer screening, diagnosis, individual treatment and prognosis .Take advantage of the high detection sensitivity of HRM, the accuracy of mutation screening method could be improved and the test cost could be reduced by combing HRM analysis with sequencing , which helps to develop the molecular diagnostic technique .