1.Marketing License System of Drugs at Home and Abroad:A Comparative Study
China Pharmacy 2007;0(34):-
OBJECTIVE:To provide reference for the evolvement of the current drug marketing license system in China. METHODS: The registry classification, the drug registration procedure and the combination of marketing license and production license both at home and abroad were analyzed comparatively. In addition, the necessity and feasibility of the drug marketing license system in China were analyzed. RESULTS & CONCLUSIONS: The current drug marketing license system that centered on license No. goes against the investigation of legal ability, drug administration mode, medicine technology transfer system and original equipment manufacture thus remains be reformed. There is still difficulty for the enforcement of drug marketing licensor system, yet it should be carried out step by step until its establishment.
2.Clinic Treatment of Infective Diabetic Foot
Chinese Journal of Nosocomiology 2006;0(03):-
OBJECTIVE To investigate the clinical characteristics and the present condition of infective diabetic foot. METHODS A total of 100 cases with infective diabetic foot were classified into the wet gangrene and composite gangrene, and treated by the systemic and local modality in combination. RESULTS The cure rate of the wet gangrene and composite gangrene was 29.5% and 18.2%, respectively and the effective rate was 83.3% and 68.2%, respectively. CONCLUSIONS The combined therapy is effective for the treatment of diabetic foot.
3.Diagnosis and treatment characters of senile patients with lumbar disc protrusion (A report of 56 cases)
Yu WEI ; Lizhen GUAN ;
Chinese Journal of Minimally Invasive Surgery 2001;0(03):-
Objective To investigate the clinical characteristics and treatment of senile patients with lumbar disc protrusion . Methods The clinical data of 56 cases of senile lumbar disc protrusion from 1990 to 2000 were reviewed retrospectively. Results 48 patients had been followed for 6 months to 7.5 years with average 4 years. Excellent and good results were 41 cases (85.4%).Conclusions There was atypical symptom in the senile patients with lumbar disc protrusion. CT was an important methods for diagnosis. The after concomitant diseases were controlled, resecting half vertebral lamina and enlarging fenestration were performed. The therapeutic results were satisfactory.
4.High-intensity Interval Training for Aerobic Capacity and Physical Health (review)
Chinese Journal of Rehabilitation Theory and Practice 2016;22(1):13-18
The high-intensity interval training often consisted of groups of interval high-intensity exercise of exhaustion or above 90%maximal oxygen consumption, which can be applied to improve aerobic capacity. Adaption of skeletal muscles might be resulted from high-intensity interval training, including recruitment, glucose metabolism and activity of mitochondrial oxidase, etc., and improve maxi-mum oxygen uptake. It has been used for physical fitness, such as weight reduction, rehabilitation of heart diseases and diabetes mellitus, etc.
5.Clinical Study of Mind- and Qi-regulating Acupuncture for the Treatment of Postoperative Gastroplegia
Shanghai Journal of Acupuncture and Moxibustion 2016;(1):34-35
Objective To investigate the clinical efficacy of mind- and qi-regulating acupuncture in treating postoperative gastroplegia.Methods Thirty-six patients with postoperative gastroplegia were randomly allocated to treatment and control groups, 18 cases each. The control group received conventional acupuncture and the treatment group, acupuncture at points for regulating mind and qi (Baihui, Sishencong and Yindang) in addition. Pre- and post-treatment Hamilton Depression Rating Scale (HAMD) scores and gastric drainage volumes, and the number of treatments and the recovery rate were recorded in the patients. Comparisons of them were made between the two groups.Results There was a statistically significant pre-/post-treatment difference in the HAMD score in the two groups (P<0.01). There was a statistically significant post-treatment difference in the HAMD score between the treatment and control groups (P<0.05). There was a statistically significant pre-/post-treatment difference in gastric drainage volume in the two groups (P<0.01). There were statistically significant differences in the number of treatments and the recovery and marked efficacy rate between the treatment and control groups (P<0.05).Conclusions Mind- and qi-regulating acupuncture helps recovery and can also reduce the number of treatments in gastroplegia patients.
6.Clinical application of anti-carbamylated protein antibody
Journal of Medical Postgraduates 2016;29(4):421-426
Rheumatoid arthritis ( RA) was a common autoimmune disease characterized with main clinical manifestations of chronic inflammation in joints.Anti-carbamylated proteins(anti-CarP)antibody, as a promising bio-marker, played a crucial role in the diagnosis of RA patients and the screening of pre-RA patients .In this article , recent progress on the study of anti-CarP antibody and RA related diseases has been reviewed , which was expected to provide new references for the diagnosis and treatment of related clinical diseases .
8.Ultraviolet radiation can improve the biological activity of titanium surface.
Yun GUAN ; Heng WANG ; Wei TENG
Chinese Journal of Stomatology 2012;47(8):510-511
Animals
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Catalysis
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Cell Adhesion
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drug effects
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radiation effects
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Humans
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Hydrophobic and Hydrophilic Interactions
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Osseointegration
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drug effects
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radiation effects
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Osteoblasts
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cytology
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drug effects
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radiation effects
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Osteogenesis
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drug effects
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radiation effects
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Photochemical Processes
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Surface Properties
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radiation effects
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Time Factors
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Titanium
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chemistry
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pharmacology
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radiation effects
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Ultraviolet Rays
9.Variations of mitochondrial gene ATP6 in type 2 diabetes mellitus
Wei YE ; Jianxin Lü ; Minxin GUAN
Chinese Journal of Laboratory Medicine 2008;31(7):807-811
Objective To investigate the correlation between the variations of mitochondrial gene ATP6 and type 2 diabetes mellitus ( T2DM ) and chronic complications. Methods Genomic DNA were extracted from 254 T2DM patients and 165 age-matched controls. After amplification of ATP6 by PCR and direct sequencing, all sequences were compared with the reference sequence (rCRS) to find out the variations. Bioinformatics and statistic method were used to analyze these variations. Results Many variations were detected respectively in T2DM patients and controls, a part of them only appeared in T2DM patients in low frequency, which has not been reported previously. Most of these variations are located in thethird and forth transmembrane helix of ATP synthase subunit 6 (ATPase6). Interestingly, these variationsalmost were detected in the non-obese T2DM patients with hypotension, including G8557A, A8563G,T8594C, C8609T, A8689G, G8998A and G9139A. Conclusions There were many variations in geneATP6 and must of them are mitochondrial SNP, while variations A8689G, T8825C, G8920A, G8998A andG9139A may be mild mutations which my increase the susceptibility of T2DM. G8557A, A8563G,T8594C, C8609T, A8689G, G8998A and G9139A may be associated with the biogenetics diseases suchdiabetes and hypertension.
10.Expression of Bcl-2, integrin ?3 protein in resected non-small cell lung cancer and its clinical relevance
Wei WANG ; Huiqiang HUANG ; Zhongzhe GUAN
China Oncology 2001;0(03):-
Purpose:To study the expressions and its clinical significances of bcl-2 and integrin?3 in human Non-small cell lung cancer(NSCLC)after radical surgical resection. Methods:Immunohistochemical (IHC) staining of bcl-2 and integrin?3 was performed on paraffin-embedded sections from 269 NSCLC patients who underwent surgery and were followed up for 1.1 to 122.2(median, 48.4) months postoperatively. Differences in survival rates and clinical characteristics were evaluated by SPSS10.0 statistical software packet. Results:The prevalence of bcl-2, integrin?3 and both these proteins expression in NSCLCs was 56.9%, 47.2% and 34.9%, respectively. Bcl-2 expression was seen more frequently in female NSCLCs and smaller tumors. Integrin?3 was seen more frequently in squamous carcinomas. Cox multivariate analysis showed that bcl-2 expression in stage Ⅱ NSCLC was an independent risk factor (5 years survival rate: 39.3% vs 52.1% P=0.04), and both bcl-2 and integrin ?3 positive in stage Ⅲa NSCLC are independent good factors(5 years survival rate: 34.5% vs 23.8% P=0.04). Conclusions:Bcl-2 and integrin ?3 are indicators of NSCLC biological behavior. Combined analysis of expression of these proteins in tumors may indicate the prognosis of NSCLC.