Objective To improve the treat effect of the orthotopic liver transplantation patients with severe sepsis. Methods Fif-ty-six post-surgery patients were enrolled in this study. Patients were divided into two groups. One was non-OLT group (A group) and the other was OLT group (B group). Besides general data, the surveillance of blood lactate, the number of failure organs, APACHE Ⅱand MODS were recorded. 28-days survival rate and follow-up were checked. Results The mortality of hospitalization in non-OLT group was 30% and 57.6% in OLT group. The level of blood lactate in OLT group at the 1 st day increased significantly, which was statistically differ-ent with that in non-OLT group (P <0.01). It decreased but kept higher than that in non-group in following seven days. The numbers of failure organs in OLT group were more than in non-OLT group (P <0.01). The continuous APACHE Ⅱ score had no significant difference between two groups. But the continuous MODS score in OLT group was higher than in non-OLT group (P <0.01). Conclusions The 28-days mortality of OLT with severe sepsis is almost two times as much as that of non-OLT. It should cause more attention. The OLT with se-vere sepsis is more likely suffered from failure organs and difficult to recovery. To assess the condition of failure organs in OLT patients with severe sepsis, MODS score is better than APACHE Ⅱ score in this study. It is suggested that the standard of score system could be improved or come up with new score for organ transplantation. It will be better if blood lactate score is included.

Objective To evaluate the curative effect of reoperation on postoperative recurrent hepatocellular carcinoma (HCC). Method From Jan.1995 to Dec. 1998, 18 recurrent HCC patients underwent 27 sessions of reoperation in our hospital. Result The mean interval between first and second operation among 18 patients was 39?14 months, and for the 9 cases, in which cancer recurred after second surgery, the mean interval between the second and the third operations was 21?4.5 months (P

MTH1 protein can mitigate DNA damage which caused by reactive oxygen species through hydrolyzing oxidized deoxy-ribonucleoside triphosphate.MTH1 is highly expressed in various cancers, so as to maintain the viability of cancer cells.MTH1 is closely related to tumor associated genes such as microRNA,RAS gene and p53 gene.Moreover, MTH1 inhibitors can selectively suppress the proliferation of cancers,which is a potential new target in tumor therapy.

Humans ; Lymphocytes ; cytology ; drug effects ; Micronucleus Tests ; Occupational Exposure ; prevention & control ; Polycyclic Aromatic Hydrocarbons ; toxicity ; Population Surveillance ; methods

0.05).The smoking group had a higher TG level and a lower HDL-C level than the control one with statistical significance(P0.05).The HL activities in serum,lung and liver of smoking group were lower than those of control group(P

Objective:In view of the different kind of equipment to develop proprietary standardization of medical equipment preventive maintenance template, and make a quantitative evaluation of effects.Methods: Set up the experimental group and control group, compare maintenance data and parameters of the quality control.Results: According to the standardization of the preventive maintenance of patient monitor template, maintenance data improved, quality indicators improved significantly.Conclusion: The establishment of the standardization of medical equipment preventive maintenance template, can improve the rate of running machines, security equipment in the best state operation, reduce the equipment failure risk, ensure the safety of the use of the equipment.

Purpose:To study the expressions and its clinical significances of bcl-2 and integrin?3 in human Non-small cell lung cancer(NSCLC)after radical surgical resection. Methods:Immunohistochemical (IHC) staining of bcl-2 and integrin?3 was performed on paraffin-embedded sections from 269 NSCLC patients who underwent surgery and were followed up for 1.1 to 122.2(median, 48.4) months postoperatively. Differences in survival rates and clinical characteristics were evaluated by SPSS10.0 statistical software packet. Results:The prevalence of bcl-2, integrin?3 and both these proteins expression in NSCLCs was 56.9%, 47.2% and 34.9%, respectively. Bcl-2 expression was seen more frequently in female NSCLCs and smaller tumors. Integrin?3 was seen more frequently in squamous carcinomas. Cox multivariate analysis showed that bcl-2 expression in stage Ⅱ NSCLC was an independent risk factor (5 years survival rate: 39.3% vs 52.1% P=0.04), and both bcl-2 and integrin ?3 positive in stage Ⅲa NSCLC are independent good factors(5 years survival rate: 34.5% vs 23.8% P=0.04). Conclusions:Bcl-2 and integrin ?3 are indicators of NSCLC biological behavior. Combined analysis of expression of these proteins in tumors may indicate the prognosis of NSCLC.

Objective To analyze the associations between alleles of TNF?-308 and myasthenia gravis(MG) and its subgroups. Methods A biallelic polymorphism at position -308 in the promoter region of TNF? was screened by polymerase chain reaction (PCR) amplification and NcoⅠ restricted enzyme. One hundred MG patients and one hundred healthy controls of Chinese were analysed. Results The allele TNF?2(A) was found significantly increased in all patients (0.32 in MG vs 0.21 in healthy controls, P0.05), showing a trend of increase in patients with an late onset of disease (0.34) compared to age matched healthy controls (0.10, P

Objective To investigate the degree of retinal development in preterm infants. Methods Flash electroretinography (ERG) was performed on 25 healthy preterm infants and 25 full-term ones, and the response of rod cells and cone cells and maximal mixed responses were recorded. The delitescence and amplitudes of a- and b-waves and the ratio of amplitudes of b-/a-wave of maximal responses were analyzed. Results Compared with the full-term infants, The delitescence of responses of rod cells in preterm infants was statistically longer (.t=11.007,P.=0.000) but without any significant changes of amplitudes (.t=1.836,P.=0.069); statistically longer delitescence (.t=2.44, P=0.010; (t=10.800,)P.=0.000) and lower amplitude (.t=5.804,P=0.000; t=5.809,P.=0.000) of a- and b-wave of maximal response were found in preterm infants group. In the response of cone cells, there were significant differences of the delitescence (.t=4.444,P.=0.000) and amplitude (.t=3.819,P.=0.000)of a-wave and delitescence of b-wave(.t=2.850,P.=0.005) between the two groups, and no statistical difference of amplitude of b-wave (.t=0.486,P.=0.628) between the two groups. The ratio of amplitudes of b-/a-wave of the maximal mixed response was not significantly different between the two groups ((.t=1.142,)P.=0.256). Conclusions The development of retinal function is slower in preterm infants than that in full-term ones.