Objective:To study the iodine nutritional status of pregnant women in Jiangxi Province, and to provide basis for iodine supplementation scientifically.Methods:In 2019, 100 counties (cities, districts, referred to as counties) of 11 cities in Jiangxi Province were selected by systematic sampling. Each county was divided into five sections according to five directions: east, west, south, north and middle. One township (street) was taken in each section, and 20 pregnant women (balanced early, middle and late pregnancy) were taken from each township (street) to detect their family salt iodine and urinary iodine levels in order to compare the levels of salt iodine and urinary iodine of different cities and the distribution of urinary iodine in different stages of pregnancy.Results:A total of 10 000 edible salt samples were collected from the families of pregnant women, the median of salt iodine was 24.53 mg/kg, the consumption rate of qualified iodized salt was 97.05% (9 705/10 000), and the iodized salt coverage rate was 99.80% (9 980/10 000). There was no significant difference in the iodine content of edible salt of pregnant women in different cities ( H = 3.42, P > 0.05). A total of 10 000 urine samples were collected from pregnant women, the median of urinary iodine was 175.58 μg/L. There was a statistically significant difference in the urinary iodine content of pregnant women in different cities ( H = 28.80, P < 0.01). There was no statistically significant difference in urinary iodine distribution of pregnant women in different stages of pregnancy (χ 2 = 5.73, P > 0.05). Conclusion:The iodine nutritional status of pregnant women in Jiangxi Province is in a suitable state, but the distribution of iodine nutritional status of pregnant women in different regions is uneven, iodine nutritional status of pregnant women in key regions should be paid attention to.

Objective:To understand the status and tendency of coal-burning-borne endemic fluorosis after implementation of prevention and control measures in Jiangxi Province.Methods:According to the requirements of the national "Coal-burning-borne Endemic Fluorosis Monitoring Program", 3 fixed monitoring villages and 5 non-fixed monitoring villages in Luxi, Shangli were selected as monitoring sites every year from 2014 to 2018, respectively, 10 households were selected by simple random method in each village to survey the usage of stove and health behavior related to the consumption of pepper. At the same time, dental fluorosis and urinary fluoride were monitored in children aged 8 - 12 years in fixed monitoring villages.Results:There were significant differences in the utilization rate of improved stoves, the utilization rate of electric cookers and the qualified rate of improved stoves in fixed monitoring villages between each year (χ 2 = 111.70, 83.96, 36.64, P < 0.05), but there was no significant difference in the correct utilization rate of qualified improved stoves(χ 2 = 2.35, P > 0.05). There were significant differences in the utilization rate of improved stoves, the utilization rate of electric cookers, the qualified rate of improved stoves and the correct utilization rate of qualified improved stoves in non-fixed monitoring villages between each year (χ 2 = 132.32, 42.63, 50.03, 15.29, P < 0.05). There was no significant difference in pepper correct drying rates between fixed monitoring villages and non-fixed monitoring villages between each year (χ 2 = 4.068, 3.436, P > 0.05), the rate of pepper correct keeping and washing methods was 100% in monitored villages each year. From 2014 to 2018, the detection rate of dental fluorosis in children aged 8 - 12 years decreased from 17.04% (106/622) to 6.68% (90/1 347), and showed a downward trend year by year (χ 2trend = 72.60, P < 0.01). The annual geometric mean of urinary fluoride of children was 0.77, 0.74, 0.71, 0.74 and 0.72 mg/L, respectively. There was no significant difference among years ( H = 4.142, P > 0.05). Conclusion:Remarkable achievements have been made in the prevention and control of coal-burning-borne endemic fluorosis in Jiangxi Province.

Objective: To analyze the clinical characteristics of Wilson's disease (WD) with onset of acute liver failure (ALF) in children. Methods: Clinical data of 19 children diagnosed with WD presented with ALF in Xi'an Children's Hospital from January 2016 to April 2021 were retrospectively analyzed, including general condition, clinical manifestation, laboratory examination, and gene detection. The children were divided into the death group and survival group according to the clinical outcome. The children who had hepatic WD with non-ALF onset during the same period were selected as the control. The general conditions and laboratory indexes were compared between death group and survival group, ALF group and non-ALF group. T-test, Mann Whitney U test or χ² test were used to compare the differences between the two groups. Results: Of the 19 WD children with ALF onset, 10 were females and 9 were males. The age of admission was (10.1±2.6) years and time to onset of first visit was 9 (4, 15) days. Among the WD children with ALF onset, 4 children were lost to follow-up, 5 cases death (death group) and 10 cases survived (survival group). The ceruloplasmin in the death group was higher than that in the survival group (0.078 (0.055, 0.105) vs. 0.033 (0.027, 0.058) g/L, Z=-2.33, P=0.020). There were 95 children who had hepatic WD with non-ALF onset. The WD patients with ALF onset were older at admission (9.9 (8.0, 11.1) vs. 5.4 (3.7, 6.9) years, Z=-5.25, P<0.001), had higher ceruloplasmin (0.060 (0.030, 0.078) vs. 0.024 (0.006, 0.060) g/L, Z=-3.11, P=0.002), 24 h urinary copper (674 (205, 1 803) vs. 149 (108, 206) μg, Z=-4.25, P<0.001), and positive rate of K-F ring [17/19 vs. 7%(7/95), χ²=50.17, P<0.001] while shorter onset time at initial visit (0.3 (0.1, 0.5) vs. 1.0 (0.7, 6.0) months, Z=-4.28, P<0.001). There was no gender difference between the two groups [9/19 vs. 61%(58/95), χ²=1.22, P=0.269]. Of the 19 WD children with ALF onset, 13 had the ATP7B gene tested, and 15 reported variants were detected. The main variations were c.2333G>T (p. Arg778Leu), c.2621C>T (p. Ala874Val) and c.2975C>T (p. Pro992Leu). The allele frequencies were 6/26(23%), 4/26(15%) and 3/26(12%), respectively. Conclusions: Children of WD onset with ALF are school-aged and above. They have an acute onset, a short course of the disease, and poor prognosis. The positive rate of K-F ring, ceruloplasmin and urinary copper are higher than those of the hepatic WD children with non-ALF onset.
Ceruloplasmin/metabolism* ; Child ; Copper/metabolism* ; Female ; Hepatolenticular Degeneration/genetics* ; Humans ; Liver Failure, Acute/therapy* ; Male ; Retrospective Studies