BACKGROUND: Although several kinds of treatment methods(destructive therapy, immunotherapy, etc) for plane warts have been attempted but there have been no entirely satisfactory treatments, because the plane wants are seen to recur frequently. OBJECTIVE: This study was aimed to evaluate the combination therapy of griseofulvin and immunotherapy(dinitrochlorobenzene=DNCB, diphenylcycloprope none=DPCP) on plane warts. METHOD: Sixteen patients(age range, 9 to 41; mean age, 21.8 years) with VPJ were treated with the combination therapy with griseofulvin(500mg/day) and single contact immunotherapy(DNCB or DPCP).
Dinitrochlorobenzene ; Griseofulvin* ; Immunotherapy ; Warts*

With isolated strams of dermatophytes, susceptibility tests were undertaken to antifungal drugs, and the results of both tests by inoculation of fungal suspensions and, fungal mats were compared, also the combined actior.s of drugs against isolated strains were evaluated, Diverse susceptibiIity patterns were observed among different fungal species, however, no arminor susceptibility differences were detected among strains of same species. Among drugs tested, tolnaftate showed the most strong antifungal ar.tion, and Ep, floccoaum was the most and T. mentagrophytes was the least sensitive species to drugs. MIC levels by mats inoculation were generally far higher than that of fungal suspension, particularly with tolnaftate it was several hundred folds higher by fungal mats inoculatian. Combined actions of drugs were generelly elevated against test strains, when miconazole cornbined with tolnaftate, the action was synergistic against T. mentagrophytes, and when tolnaftate combined with griseofulvin or siccarin cornbined with griseofulvin, thactions were elevated to T. rubrum.
Arthrodermataceae* ; Griseofulvin ; Miconazole ; Suspensions ; Tolnaftate

A Case of fungus corneal ulceration of the left eye was presented. The fungus was classified as a Tricophyton. The eye was treated successfully with Griseofulvin and chymotrypsin.
Chymotrypsin ; Corneal Ulcer* ; Fungi* ; Griseofulvin

In vitro sensitivity of T. mentagrophytes against antifungal agents was investigated. The 20 strains of T. mentagrophytes were tested. They were 5 strains of granilar form, 5 of powdery form, 5 of persicolor form, and 5 of downy for m. The tested antifungal agents were griseofulvin, ket,oconazole and it,raconazole. The results were as follows : 1. Minimal inhibitory concintration(MIC) of antifungal agents against, T. mentagrophytes : MIC of griseofulvin was 3.13-25 ug/ml, the highest level, that of ketoconazole was 0.05-12 ug/ml, and that of itraconazole was 0.025 6.25 ug/ml, the lowest one. 2. MIC of antifungal agents against T. mentagrophytes strains. MlC of griseofulvin was 12-25 ug/ml on granular form and 3.13-25 ug/ml on the other forms. MIC of ketoconazole was 0.39-12 ug/ml on granular form, 0,05 0.78 ug/ml on powdery form, 0.05 12 ug/ml on persicolor form, and 0.1-12 ug/ml on downy form. MIC of itraconazole was 0.39-6.25 ug/ml on granular form, 0.05-0.39 ug/ml on powdevy form, 0.025-0.05 ug/ml on persicolor form, and 0.05-0.1 ug/ml on downy form. Granular form showed the highest level of MIC among antifungal agents. These findings suggesed that, itraconazole was the most arctive drug against T. mentagrophytes and the pranular form showed the lowest, sensirivity against antifungal agents.
Antifungal Agents* ; Griseofulvin ; Itraconazole ; Ketoconazole ; Trichophyton*

Tinea capitis in the neonatal period is extremely rare. To our knowledge, there have been only a few reports of neonatal tinea capitis in the Korean dermatologic literature. We report an additional case of neonatal tinea capitis caused by Microsporum canis. The patient was successfully treated with oral griseofulvin.
Griseofulvin ; Humans ; Microsporum ; Tinea Capitis* ; Tinea*

Five secondary metabolites, including a new isopimarane derivative xylaroisopimaranin A (1), were isolated from the endophytic fungus Xylaralyce sp. (HM-1), and their structures were elucidated by 1D, 2D NMR, MS and CD spectra. Their bioactivities were performed to antibacterial, Hep G2 cells cytotoxicity and brine shrimp inhibition. The biological evaluation results showed that the xylaroisopimaranin A (1), xylabisboein B (2), griseofulvin (3) , 5-methylmellein (4) and mellein-5-carboxlic acid (5) displayed no significant Hep G2 cells cytotoxicity and antibacterial acitivity, but they inhibited the brine shrimp with IC₅₀ from 0.5 to 25 µmol/mL.
Artemia ; Fungi ; Griseofulvin ; Hep G2 Cells

This study was undertaken to evaluate the efficacy and safety of orally administered ketoconazole in the treatment of onychomycosis. Thirteen patients with onychomycoiis were selected for this study. For evaluation of ketoconazole efficacy twelve patients received a 200 mg tablet of ketoconazole daily and one patient received a. 10() mg tablet of ketoconazole daily. All patients were studied monthly clinically and mycologically by KOH mount and culture on Sabourauds medium. The results were as follows: 1. Seven(53.8%) of thirteen cases achieved remission, marked improvement occurred in three cases(23.1%) and moderate improvement occurred in three cases (23. 1 %). 2. The mean duration of remission or clinical improvement was 5 months for all lesions and toenail lesions(5. 4 months) took longer to heal than finger nail lesions (4 months). 3. One hundred percent of patient who previously failed to respond to griseofulvin were cured or clinically improved by ketoconazole. 4. Two patients cornplained of indigestion and one of headache. In our study, ketoconazole was highly effective in the treatment of onychomycosis.
Dyspepsia ; Fingers ; Griseofulvin ; Headache ; Humans ; Ketoconazole* ; Nails ; Onychomycosis*

The present study was designed to obtain omparative data on in vitro antifungal activities of imidazole derivatives. Minimum inhibitory oncentrations of clotrimazole, miconazole, econazole, ketoconazlole and griseofulvin on 4 strains of Trichophyton mentagrophytes, 3 strains of Trichophyton rubrum, 2 strains of Microsporum canis and ] strain of Sporothriv: schenckii were etermined after 3 week' incubation at room temperature on Sabouraud's dextrose liquid media. In addition, the fungicidal activities of miconazole and econazole were tested against Z'richophyton mentagrophytes and Microsporum canis, using the techniques described by Vanbreuseghern(1967) The results are summarzed as follows: ] In most of the dermatophytes studied, 1 to 10 pg/ml of M1C were detected. Diverse susceptibility pattern was observed among different fungal species, but no or minor variability was noted within the same species. The susceptibility of Z'ri- chophyton rubrum showed at MIC of 0. 01 to 10 pg/ml, T ichophyton mentagro- phyt.es and Mic osporum canis at 0.1 to 10 pg/ml and 0. 1 to 1000 gg/ml respec- tively. The Trichophyton rubrum was the most sensitive. In the susceptibility test of Sporothrix schenckii, the high resistance to clotrimazole and griseofuhin was observed. The fungistatic activities of miconazole, econazole and ketoconazole were observed only at concentrations higher than JpQ pg/ml.
Arthrodermataceae ; Clotrimazole ; Econazole ; Glucose ; Griseofulvin ; Ketoconazole ; Miconazole ; Microsporum ; Sporothrix ; Trichophyton

We report three cases of kerion celsi caused by Trichophyton tonsurans in 16-year-old students of one high school wrestling team. The first case presented a 10x5cm and several 3~4cm sized, markedly inflammatory, boggy lesions on the scalp for 5 months. Other cases showed several 2~4cm sized, erythematous, follicular pustules and nodules with partial alopecia on the scalp for 2 months. Histopathology and results of mycologic study were consistent with kerion celsi due to Trichophyton tonsurans. All lesions were successfully treated with griseofulvin 500mg daily for 7~15weeks and short term therapy of low dose of prednisolone and cephadroxil.
Adolescent ; Alopecia ; Griseofulvin ; Humans ; Prednisolone ; Scalp ; Tinea Capitis* ; Trichophyton* ; Wrestling

We report a case of a phototoxic reaction in a 48-year-old female induced by griseofulvin ingestion. The patient hac! erythematous papules, vesicles and patches on the sun-exposed areas. Phototest revealed a decreased minimal erythemal dose to UVA (10J/cm). Photopatch tests with 1%, 5%, 10% Griseofulvin ointment and vaseline as a control and photoingestion tests with Griseofulvin (50mg b.i.d.) were all negative. After the cessation of Griseofulvin, her skin lesions were markedly improved with complete loss of photosensitivity.
Eating ; Female ; Griseofulvin ; Humans ; Middle Aged ; Petrolatum ; Skin