BACKGROUND: To evaluate the utilization of point-of-care ultrasound (POCUS) for the assessment of emergency department (ED) patients with musculoskeletal symptoms and the impact of musculoskeletal POCUS on medical decision-making and patient management in the ED. METHODS: This was a retrospective review of ED patients presenting with musculoskeletal symptoms who received a POCUS over a 3.5-year period. An ED POCUS database was reviewed for musculoskeletal POCUS examinations used for medical decision-making. Electronic medical records were then reviewed for demographic characteristics, history, physical examination findings, ED course, additional imaging studies, and impact of musculoskeletal POCUS on patient management in ED. RESULTS: A total of 264 subjects (92 females, 172 males) and 292 musculoskeletal POCUS examinations were included in the final analysis. Most common symptomatic sites were knee (31.8％) and ankle (16.3％). Joint effusion was the most common finding on musculoskeletal POCUS, noted in 33.7％ of the patients, and subcutaneous edema/cobblestoning was found in 10.2％ of the patients. Muscle or tendon rupture was found in 2.3％ of the patients, and 1.9％ of the patients had joint dislocation. Bursitis or bursa fluid was found in 3.4％ of patients, and tendonitis/tendinopathy was found in 2.3％. Twenty percent of them were ultrasound-guided musculoskeletal procedures, and most of them (73.3％) were arthrocentesis. Of the included studies, all except three either changed or helped guide patient management as documented in the patients' medical records. CONCLUSION: Our study findings illustrate the utility of POCUS in the evaluation of a variety of musculoskeletal pathologies in the ED.