1.Attractin.
Shi-liang SHEN ; Gregory S BARSH ; Zhong-bi WU
Chinese Journal of Pathology 2005;34(7):429-431
Agouti Signaling Protein
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Animals
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Central Nervous System
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abnormalities
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metabolism
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pathology
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Energy Metabolism
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Hair Color
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genetics
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physiology
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Humans
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Intercellular Signaling Peptides and Proteins
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metabolism
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Membrane Proteins
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genetics
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metabolism
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physiology
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Mutation
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Obesity
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genetics
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metabolism
2.Superior Mesenteric Artery Syndrome: Late Complication of Ileal Pouch-Anal Anastomosis
Gregory WU ; Brianna BOCKMAN ; Mohammad SABA ; Abiola MOSURO
Journal of Acute Care Surgery 2022;12(2):86-89
Superior mesenteric artery syndrome (SMAS) is an uncommon condition which is difficult to diagnose due to non-specificity of symptoms. The most common causes of SMAS are severe weight loss secondary to severe medical conditions, surgical history, and cancer. A 31-year-old male with a history of ulcerative colitis status-post proctocolectomy with ileal pouch-anal anastomosis 10 years prior, presented with progressively worsening weight loss and abdominal pain. Radiographic imaging was consistent with SMAS, which was subsequently confirmed intraoperatively during an emergency surgery in which a Roux-En-Y gastrojejunostomy was performed. Clinicians should be aware that SMAS is a rare but possible complication of ileal pouch-anal anastomosis. Although rare, there should be a low threshold for this diagnosis when obstructive symptoms present.
3.Evaluation of oxidative stress in experimental rabbit aneurysms.
Li LI ; Xin-jian YANG ; Fan JIANG ; Ai-hua LIU ; Zhong-xue WU ; Gregory J DUSTING
Acta Academiae Medicinae Sinicae 2006;28(5):707-709
OBJECTIVETo evaluate the roles of oxidative stress in the generation and development of aneurysms.
METHODSFive terminal aneurysms and 8 lateral aneurysms were rebuilt on rabbits, and 6 normal artery vessels were prepared as control. The levels of malondialdehyde (MDA), superoxide dismutase (SOD), and anti-reactive oxygen species unit (anti-ROS unit) were measured with chemical methods.
RESULTSThe levels of MDA in terminal and lateral aneurysms were (33.85 +/- 8.66) and (27.87 +/- 5.78) nmol/mg prot, respectively, which were significantly higher than (10.91 +/- 2.72) nmol/mg prot in control group (P < 0.01). The levels of SOD in terminal and lateral aneurysms were (28.30 +/- 3.58) and (33.00 +/- 8.09) U/mg prot, respectively, which were significantly lower than (127.27 +/- 38.72) U/mg prot in control group (P < 0.01). The levels of anti-ROS unit in terminal and lateral aneurysms were (47.86 +/- 5.00) and (62.64 +/- 13.87) U/ mg prot, respectively, which were significantly lower than (116.94 +/- 9.22) U/mg prot in control group (P < 0.01). No significant differences were shown between terminal aneurysm and lateral aneurysm in MDA and SOD except anti-ROS unit (P = 0.014). MDA had negative correlations with both SOD and anti-ROS unit, and the correlation coefficients were -0. 830 and -0. 852, respectively.
CONCLUSIONOxidative stress may play an important role in the development of aneurysms. Oxidative stress seems similar among various aneurysms.
Aneurysm ; classification ; metabolism ; Animals ; Disease Models, Animal ; Malondialdehyde ; metabolism ; Oxidative Stress ; Rabbits ; Reactive Oxygen Species ; metabolism ; Superoxide Dismutase ; metabolism
4.Profiles of women presenting for abortions in Singapore at the National University Hospital: focus on married women.
Xiang Wen Gregory PEK ; Wei Shan TEOH ; Duoduo WU ; Kuldip SINGH
Singapore medical journal 2023;64(5):302-306
INTRODUCTION:
In this study, we aimed to identify the differences in sociodemographic variables and reasons for termination of pregnancy (TOP) between married women and single/divorced women. We hope that this study can guide future policies and interventions to reduce the incidence of unsupported pregnancies in this profile group of women.
METHODS:
We retrospectively evaluated the sociodemographic data of 802 women who underwent an abortion for social reasons at our institution in Singapore from January 2016 to September 2018. We compared the sociodemographic variables, reasons for and methods of TOP between married and single/divorced women.
RESULTS:
We analysed data from 524 married women (65.3%) and 278 single/divorced women (34.7%). Married women were more likely to be of older age (29.5 years vs. 24.5 years, P < 0.001), had more living children and higher educational qualifications. The top two cited reason for abortions among married women were having enough children (42.0%) and the inability to afford another child (18.7%). Multivariate analysis showed that women aged >19 years and having more living children were independently associated with recurrent TOPs. Having a tertiary education was noted to be associated with less recurrent TOPs.
CONCLUSION
The most common reasons married women cited for having TOP include having enough children and the lack of financial capacity to afford another child. Recommendations to support women ought to be personalised and comprehensive in addressing their needs rather than offering a standardised support method. Greater emphasis should be placed on post-TOP family planning counselling to reduce repeated TOP.
Pregnancy
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Child
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Female
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Humans
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Retrospective Studies
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Singapore/epidemiology*
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Abortion, Induced
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Hospitals, University
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Educational Status