Granuloma annulare is a benign, self-limiting dermatosis of unknown cause, and is characterized by necrobiotic dermal papules that often assume an annular configuration. A generalized form is common in the fifth to seventh decades of age, however, it is uncommon in childhood, especially in infancy. We report an interesting case of generalized grannuloma annulare which occurred in a 60 day-old boy. Dermatologists should include generalized granuloma annulare in the differential diagnosis of infants with generalized papular eruptions.
Diagnosis, Differential ; Granuloma Annulare* ; Granuloma* ; Humans ; Infant* ; Male ; Skin Diseases

We have experienced 4 cases which were clinically diagncsed as granuloma pyogenicum, but histologically as a malignant melanorna, an eccrine angiomatous hamartoma with granuloma pyogenicum, a subungual exostosis, and a lipoma, with granulation tissue. A granuloma pyogenicum may have clinical resemblances to various benign or malignant lesions. Therefore, any lesion that resembles a granuloma pyogenicum should have this clinical impression confirmed by histologic examination.
Diagnosis, Differential ; Exostoses ; Granulation Tissue ; Granuloma* ; Granuloma, Pyogenic* ; Hamartoma ; Lipoma

Periapical cemental dysplasia(PCD) is a condition most commonly seen in the mandibular incisor region. Radiographically it passes through the three phases(osteolytic stage, intermediate stage, and mature stage). At osteolytic stage, the lesion is similar to features associated with granuloma or cyst that arise following pulpal necrosis. So, it is important to confirm the vitality of the pulp to diagnosis. In this case, it is difficult to confirm the vitality of involved tooth because the tooth was covered with PFG bridge. And it is unusual that the PCD lesion at mandibular incisors has occurred at first and the lesion of mandibular canine and mandibular premolar were occurred afterward.
Bicuspid ; Diagnosis* ; Granuloma ; Incisor ; Necrosis ; Tooth

Diagnosis, Differential ; Granuloma/diagnosis* ; Humans ; Lung ; Lung Diseases/diagnosis*

Lipogranuloma is a rare benign disease accompanied by a reactive inflammatory process related to exogenous or endogenous lipids. We report a case of lipogranuloma of the lung mimicking pulmonary neoplastic disease in a 57-year-old woman, who presented with the symptom of coughing for a month. The diagnosis of lung cancer was considered for the CT finding of a mass in right lower lobe. The patient underwent subsequent operation, and pathological examination of the surgical specimen revealed a stromal lesion consisting of lipid vacuoles with foreign body type giant cells and scattered lymphocytes. The final diagnosis of lipogranuloma of the lung was established. Clinicians should be aware of lipogranuloma in the lung, which can be easily confused with lung tumors or other benign diseases. A careful differential diagnosis is necessary.
Female ; Granuloma ; diagnosis ; Humans ; Lung Neoplasms ; diagnosis ; Middle Aged

Diagnosis, Differential ; Granuloma, Lethal Midline ; diagnosis ; therapy ; Humans ; Infant ; Male

Eosinophilic granuloma of the cervical spine is an uncommon disease. A 20-year old male patient noticed cervical pain, restricted range of movement, torticollis and tenderness. On computed tomographic scan, myelographic imaging and plain radiographic imaging demonstated a bony destruction in the left side of the third cervical vertebral body and a part of the pedicle. Preoperative radioisotope bone scan demonstrated an hot uptake in the third cervical vertebral body. Gross total removal of the lesion and radiation therapy were performed. Postoperative course was favorable. The lesion is readily curable and should be considered in the diferential diagnosis of pain or neurological deficit in association with a lytic defect in the cervical spine. Occasionally, a solitary lesion characteristic of eosinophillic granuloma in found in cases of otherwise classic Hand-Schuller-Christian. So, close chinical and radiologic follow-up sholuld be obtained.
Diagnosis ; Eosinophilic Granuloma* ; Eosinophils* ; Follow-Up Studies ; Granuloma ; Humans ; Male ; Neck Pain ; Spine* ; Torticollis ; Young Adult

We report two cases showing typical clinical features of subcutaneous granuloma annulare. Clinically, rapidly growing non-tender subcutaneous nodules developed on the scalp of healthy children without histories of trauma or infection. Histopathologically, collagen degeneration surrounded by histiocytes and lymphocytes in a palisading arrangement were seen in the deep dermis and subcutaneous layer. The foci of degeneration contained pale and edematous basophilic mucinous deposits. The skin lesions resolved spontaneously without specific treatment. Subcutaneous granuloma annulare should be considered in the differential diagnosis of children presenting with soft tissue masses.
Basophils ; Child ; Collagen ; Dermis ; Diagnosis, Differential ; Granuloma Annulare* ; Granuloma* ; Histiocytes ; Humans ; Lymphocytes ; Mucins ; Scalp ; Skin

Pyogenic granuloma is a lobular capillary hemangioma that occurs mostly on the skin and the mucosal surfaces of the oral cavity and tongue. Only a few cases in other parts of the digestive tract have been reported. Gastrointestinal pyogenic granuloma is a rare cause of hemorrhage in the digestive tract, but should be considered in the differential diagnosis of patients with gastrointestinal bleeding. We report the case of a 62-year-old anemic woman found to have a pyogenic granuloma of the duodenum, which was treated adequately by endoscopic mucosal resection.
Diagnosis, Differential ; Duodenum ; Female ; Gastrointestinal Tract ; Granuloma ; Granuloma, Pyogenic ; Hemorrhage ; Humans ; Middle Aged ; Mouth ; Skin ; Tongue

We observed the histopathologic findings of 21 biopsed materials those initial clinical impression was suspected as granuloma pyogenicum. Also we compared the cange in the number of mast cells in the lesion of the granuloma pyogenicum with those in the normal appearing skin by Giemsa stain, and the stainability of mucopolysaccharides in the stromal edema of granuloma pyogenicum lesion with that in the normal appearing skin by Alcian blue-PAS stain. The results were as fallows: The various microscopic diagnoses made in 8 cases, which was clinically granuloma pyogenicurn. These 8 cases were granulation tissue(3), subungual exostosis(1), dermatofibrorna(1), sebaceous epithelioma(l), liporna with granulation tissue(1), and malignant melanoma(1). 2. The number of mast cells in the granuloma pyogenicum lesion were increased (p<0.01), especially in the lesion which showed marked capillary endothelial proliferation, and the amount of mucopolysaccharides was increased in the stromal edema of the granuloma pyogenicum lesion.
Azure Stains ; Capillaries ; Diagnosis ; Edema ; Glycosaminoglycans ; Granuloma* ; Granuloma, Pyogenic* ; Mast Cells ; Skin