Female ; Granuloma, Respiratory Tract ; pathology ; Humans ; Middle Aged ; Sarcoidosis, Pulmonary ; pathology

Adult ; Female ; Granuloma, Respiratory Tract ; pathology ; Humans ; Lung, Hyperlucent ; pathology ; Male ; Middle Aged

Inflammatory pseudotumor is a infrequent, benign tumor that affects at all ages and involves the lung, gastrointestinal tract, and salivary gland. They are the most common, isolated, primary lesion of the lung in children, and usually present as circumscribed, peripheral, parenchymal tumors or endobronchial tumors, which may be usually static or increase slowly in size without causing symptoms. Surgical excision is the treatment of choice because of the location and benign nature of this lesion. The prognosis after resection is excellent. Other therapeutic modalities include radiation and steroid therapy. We experienced two cases of inflammatory pseudotumor of the lung parenchyme and endobronchus. We report these cases with a review of literatures.
Child ; Gastrointestinal Tract ; Granuloma, Plasma Cell* ; Humans ; Lung ; Prognosis ; Respiratory System* ; Salivary Glands

Adult ; Granuloma, Respiratory Tract ; microbiology ; Humans ; Male ; Mycoses ; diagnosis ; therapy ; Pharyngeal Diseases ; diagnosis ; microbiology ; therapy

The causes of dysphonia can be classified into two groups, organic and functional. Functional dysphonia includes spasmodic dysphonia, muscle tension dysphonia, mutational dysphonia and conversion dysphonia, etc. The findings of laryngoscopy in these dysphonia are almost normal. Organic dysphonia is caused by anatomical problems in the larynx, especially on the vocal fold. Benign diseases of the vocal folds are common and mainly presented as voice disorders such as hoarseness, harshness, weakness, or even loss of voice. Benign neoplasm of the larynx are very rare condition except papilloma. The most common symptoms are voice change. However, they can be presented as wheezing, dyspnea, discomfort in the throat, or cervical mass depending on the size and location of the tumor. Detailed history taking and thorough laryngeal endoscopic examination are necessary for the appropriate diagnosis and treatment.
Dysphonia ; Dyspnea ; Granuloma ; Hoarseness ; Laryngoscopy ; Larynx ; Muscle Tonus ; Papilloma ; Papillomavirus Infections ; Pharynx ; Respiratory Sounds ; Respiratory Tract Infections ; Vocal Cords ; Voice ; Voice Disorders

Inflammatory pseudotumor is a benign disease entity, which is histologically composed of inflammatory cells and fibrotic stroma. It is mainly found in the respiratory tract, but it has also been reported in the liver, central nervous system, soft tissues, urological system, and gastrointestinal tract. It is extremely rare in the spleen and there have been no cases of splenic inflammatory pseudotumor associated with autoimmune thyroiditis in Korea. The pathogenesis or etiology is unknown, but hypotheses include infection, autoimmunity, and parenchymal necrosis with hemorrhage. Because inflammatory pseudotumor may mimic malignant tumors on radiologic findings, pathologic confirmation is necessary to distinguish it from lymphoproliferative disorders of the spleen and other malignant tumors. We report a case of inflammatory pseudotumor of the spleen associated with autoimmune thyroiditis in a patient who complained of periumbilical pain.
Autoimmunity ; Central Nervous System ; Gastrointestinal Tract ; Granuloma, Plasma Cell* ; Hemorrhage ; Humans ; Korea ; Liver ; Lymphoproliferative Disorders ; Necrosis ; Respiratory System ; Spleen* ; Thyroiditis, Autoimmune*

Natural killer (NK)/T cell lymphoma is a lethal midline granuloma that produces necrotic and granulomatous lesions in the upper respiratory tract, especially in the nasal cavity. This tumor affects the nose and midface, but can also arise in the skin, gastrointestinal tract, testes, central nervous system, lungs, salivary glands, bone marrow, and larynx. Five to eight percent of extranodal lymphomas involve the orbit, and 1.3~2.0% of these present as primary orbital tumors. The skin can also be the primary site of NK/T cell lymphomas. Aside from affecting the nasal and facial skin, the tumor can involve the skin of the postauricular area, back, trunk, and upper and lower extremities. We present the case of a 37-year-old woman who had a nasal NK/T cell lymphoma with cutaneous and ocular involvement.
Adult ; Bone Marrow ; Central Nervous System ; Female ; Gastrointestinal Tract ; Granuloma, Lethal Midline ; Humans ; Larynx ; Lower Extremity ; Lung ; Lymphoma ; Nasal Cavity ; Nose ; Orbit ; Respiratory System ; Salivary Glands ; Skin ; Testis

Alveolitis, Extrinsic Allergic ; diagnosis ; pathology ; Biopsy ; Chronic Disease ; Cryptogenic Organizing Pneumonia ; diagnosis ; Diagnosis, Differential ; Granuloma, Respiratory Tract ; diagnosis ; Humans ; Idiopathic Interstitial Pneumonias ; diagnosis ; Idiopathic Pulmonary Fibrosis ; diagnosis

Good's syndrome is extremely rare. This adult-onset condition is characterized by a thymoma with immunodeficiency, low B- and T-cell counts, and hypo-gammaglobulinemia. The initial clinical presentation is either a mass-lesion thymoma or a recurrent infection. Patients with Good's syndrome are very susceptible to infections; common respiratory and opportunistic infections can be life-threatening. There are no reports of granulomatous lung disease in patients with Good's syndrome, although it has been observed in patients with common variable immunodeficiency, of which Good's syndrome is a subset. We describe a 53-year-old male thymoma patient who presented with respiratory symptoms caused by granulomatous lung disease and an opportunistic infection. He died of uncontrolled fungal infection despite repeated intravenous immunoglobulin and supportive care. Clinicians should look for evidence of immunologic dysfunction in thymoma patients presenting with severe recurrent infections, especially opportunistic infections.
Fatal Outcome ; Granuloma, Respiratory Tract/diagnosis/*etiology/therapy ; Humans ; Immunologic Deficiency Syndromes/*complications/immunology/pathology ; Lung Diseases/diagnosis/*etiology/therapy ; Male ; Middle Aged ; Thymoma/*complications/immunology/pathology ; Thymus Neoplasms/*complications/immunology/pathology

OBJECTIVETo explore the source of the fine particulate matter (PM(2.5)) in the sarcoidosis granulomatous cell and the relationship between the sarcoidosis and the PM(2.5) in the atmosphere.

METHODSParaffin-embedded tissues of 50 cases of human sarcoidosis biopsy samples, 10 cases of non-sarcoidosis autopsy lung samples, 18 cases of lung tissues (with granulomatous lesions) of rats exposed to PM(2.5) by bronchial infusion, and the free PM(2.5) sample in the atmosphere were collected. The characteristics of tissues above mentioned were observed under the light microscopy, which stained by HE staining and Warthin-Starry silver staining. The characteristics of the PM(2.5) in the four groups were analyzed using confocal Raman microscopy. The component of the PM(2.5) in the sarcoidosis granuloma was analyzed using transmission electron microscope-energy dispersive X-ray detector (TEM-EDX), and the component of the PM(2.5) in the atmosphere was analyzed with X-ray fluorescence separately.

RESULTSThe PM(2.5) in the four groups have the similar Raman spectrum, they share the feature of carbonaceous composition, the element component of PM(2.5) in the human sarcoidosis was the same as PM(2.5) in the atmosphere.

CONCLUSIONThe study provided the further evidence that the PM(2.5) in the sarcoidosis lesion was from PM(2.5) in the atmosphere, and it should be not excepted that sarcoidosis may be a sensitive individual reaction to the PM(2.5) inhaled from the atmosphere.

Adolescent ; Adult ; Aged ; Air Pollutants ; analysis ; Aluminum ; analysis ; Animals ; Carbon ; analysis ; Child ; Female ; Granuloma ; metabolism ; pathology ; Granuloma, Respiratory Tract ; metabolism ; pathology ; Humans ; Lung ; chemistry ; Male ; Middle Aged ; Particle Size ; Particulate Matter ; analysis ; chemistry ; Rats ; Sarcoidosis ; metabolism ; pathology ; Sarcoidosis, Pulmonary ; metabolism ; pathology ; Silicon ; analysis ; Skin Diseases ; metabolism ; pathology ; Spectrum Analysis, Raman ; Young Adult