No abstract available.
Graft vs Host Disease*

No abstract available.
Graft vs Host Disease* ; Warts*

Graft-versus-host disease occurs after the administration of foreign immunologically competent cells to an individual who is immunologically compromised. It is a clinical syndrome characterized by cutaneous changes, gastrointestinal dysfunction and liver dysfunction. Cutaneous graft-versus-host reaction is usually the earliest and certainly the most common form of the disease. The diagnosis of graft-versus-host disease is a complex clinicopathologic skill requiring considerable experience. There as yet appears to be no pathognomonic single clinical or histologic feature in the acute phase. In this review article, the definition, immunological aspects and. clinical features of graft-versus-host disease, diagnostic criteria of acute cutaneous graft-versus-host reaction and graft-versus-tumor effect are discussed.
Diagnosis ; Graft vs Host Disease ; Liver Diseases

No abstract available.
Graft vs Host Disease* ; Liver Transplantation*

No abstract available.
Graft vs Host Disease* ; HLA-DR Antigens

No abstract available.
B-Lymphocytes ; Graft vs Host Disease

Chimerism ; Graft vs Host Disease ; Liver Transplantation

Subacute radiation dermatitis is a cutaneous disorder that occurs secondary to radiation exposure. It occurs after weeks to a few months from radiation exposure. Histologically, subacute radiation dermatitis presents with interface dermatitis that resembles graft-versus-host disease or a fixed drug eruption. The previous reports on this disease have usually been related to extensive or repeated coronary angiography. Herein, we report on a case of subacute radiation dermatitis that occurred 5 weeks after cardiac intervention therapy.
Coronary Angiography ; Dermatitis ; Drug Eruptions ; Fluoroscopy ; Graft vs Host Disease

PURPOSE: To evaluate the therapeutic effects of 0.03% tacrolimus eye drops on dry eye associated with chronic ocular graft-versus-host disease (GVHD). METHODS: This study included 24 eyes of 12 patients with refractory dry eye associated with chronic ocular GVHD who were unresponsive to topical steroid and 0.05% topical cyclosporine. The topical steroid and cyclosporine were discontinued for 2 weeks before treatment and 0.03% tacrolimus eye drops were applied twice a day for 1 month. Artificial tears, ointment, and lid cleanser were used in the same manner before initiating tacrolimus treatment. Ocular staining score, tear break-up time, ocular surface disease index (OSDI), and Schirmer I test score were evaluated. RESULTS: Ocular staining score, tear break-up time, and OSDI improved with statistical significance (p < 0.05) after 28 days of treatment. Schirmer I test did not show statistical improvement after treatment. CONCLUSIONS: The use of 0.03% tacrolimus eye drops were effective for refractory dry eye associated with chronic ocular GVHD.
Cyclosporine ; Graft vs Host Disease* ; Humans ; Ophthalmic Solutions* ; Tacrolimus* ; Tears

NKT cells (nature killer T cells), as a regulatory cellular compartment in the immune system, express cell surface markers of T cells and NK cells. It secretes a variety of cytokines that stimulate specific antigens. Through regulating the balance of Th1/Th2, the NKT cells play an important role in prevention and treatment of graft-versus-host disease (GVHD). Its antitumor and anti-infectious effects serve as a basis of its application in allogeneic hematopoietic stem cell transplantation. A better understanding of the biological and immunological features of NKT cell, as well as its specific immune regulatory mechanisms, will further justify the rationales of using NKT cells in the management of GVHD for patients. In this review, the biologic properties, classification, differentiation and development, immune activation of NKT cells as well as the NKT cells and GVHD including the related mechanisms of prevention and treatment of GVHD with NKT cells, NKT cells and tumors, NKT cells and infection, and NKT cells and clinical GVHD are summarized.
Animals ; Graft vs Host Disease ; Humans ; Natural Killer T-Cells