1.Effects of Combined Therapy with Ezetimibe Plus Simvastatin After Drug-Eluting Stent Implantation in a Porcine Coronary Restenosis Model.
Jung Sun CHO ; Myung Ho JEONG ; Doo Sun SIM ; Young Joon HONG ; Kyung Seob LIM ; Jung Ha KIM ; Hyoung Doo KIM ; Ju Yeal BAEK ; Hee Jeoung YOON ; Sung Ho HER ; Seung Won JIN ; Ju Han KIM ; Youngkeun AHN ; Jeong Gwan CHO ; Jong Chun PARK ; Jung Chaee KANG
Journal of Korean Medical Science 2010;25(5):716-722
The aim of this study was to examine the anti-proliferative and anti-inflammatory effects of ezetimibe/simvastatin (E/S) after drug-eluting stent (DES) implantation in a porcine coronary restenosis model. Pigs were randomized into two groups in which the coronary arteries (23 pigs) had DES. Stents were deployed with oversizing (stent/artery ratio 1.3:1) in porcine coronary arteries. Fifteen pigs were taken 10/20 mg of E/S and eight pigs were not taken E/S. Histopathologic analysis was assessed at 28 days after stenting. In neointima, most inflammatory cells were lymphohistiocytes. Lymphohistiocyte count was not different between two groups (337+/-227 vs. 443+/-366 cells, P=0.292), but neointima area was significantly smaller (1.00+/-0.49 mm2 vs. 1.69+/-0.98 mm2, P=0.021) and percent area stenosis was significantly lower (23.3+/-10% vs. 39+/-19%, P=0.007) in E/S group compared with control group. There were no significant differences in fibrin score (1.99+/-0.79 vs. 1.81+/-0.88, P=0.49), endothelial score (1.75+/-0.66 vs. 1.80+/-0.59, P=0.79), and the percent of endothelium covered lumen (43+/-21% vs. 45+/-21%, P=0.84) between E/S group and control group. Combined therapy with ezetimibe and simvastatin inhibits neointimal hyperplasia, but does not inhibit inflammatory infiltration and arterial healing after DES implantation in a porcine coronary restenosis model.
Animals
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Anticholesteremic Agents/administration & dosage
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Azetidines/*administration & dosage
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Coronary Restenosis/diagnosis/drug therapy/*etiology
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*Disease Models, Animal
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Drug Combinations
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Drug Implants/administration & dosage
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Drug-Eluting Stents/*adverse effects
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Female
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Graft Occlusion, Vascular/diagnosis/*drug therapy/*etiology
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Humans
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Hydroxymethylglutaryl-CoA Reductase Inhibitors/administration & dosage
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Simvastatin/*administration & dosage
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Swine
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Treatment Outcome