Tuberous Sclerosis Complex (TSC) is a genetic disorder that presents in a myriad of
clinical manifestations affecting the different organ systems. These manifestations emerge at
different times in a patient’s lifespan and diagnosis early in the disease can be challenging.
Majority of patients with TSC develop epilepsy and is often one of the most difficult to manage.
We report two neonates with drug resistant epilepsy with seizure onset on the first day of life
and were subsequently diagnosed with Tuberous Sclerosis. These two neonates exemplified the
diverse phenotypic expression of TSC.