1.Single lesion Lepromatous Leprosy in a teenager: An unexpected scenario
Carmella Jane C. Luis ; Grace Monica Ibaviosa ; Johannes F. Dayrit
Journal of the Philippine Dermatological Society 2018;27(2):91-93
Introduction:
Hansen’s disease (HD) is a chronic granulomatous disease principally affecting the skin and peripheral
nervous system caused by Mycobacterium leprae. The incubation period varies from months to more than 30 years.
The tuberculoid form of HD usually presents with a single hypoesthetic patch and skin biopsy shows epithelioid
granulomas with absence of bacilli on Fite-Faraco stain. In contradistinction, lepromatous leprosy usually presents
with numerous papules, plaques and nodules with induration of the ears and nose. Biopsy shows foamy granulomas
with presence of acid-fast bacilli on Fite-Faraco stain.
Case summary:
We present a case of a 13-year old female who presented with a 3-year history of a single
hypoesthetic patch on the left knee. The initial clinical diagnosis was tuberculoid leprosy. However, histopathology
revealed a Grenz zone, and a nodular granulomatous infiltrate consisting of epitheloid and foamy histiocytes with
scattered lymphocytes. Fite-Faraco stain showed a bacillary index (BI) of 3+. Slit-skin smear revealed a BI of 4+. She
was then started on multidrug therapy.
Conclusion
This case highlights the importance of slit-skin smear and biopsy as routine procedures in all new cases
of suspected HD. These procedures will help differentiate multibacillary from paucibacillary forms of the disease
which will influence decisions for treatment and prognostication. This case emphasizes that lepromatous leprosy
may present with single lesions and may be misdiagnosed as paucibacillary leprosy if skin-slit smear and biopsy have
not been done. This case further suggests that there are factors yet undetermined which play significant roles in
determining the host response to M. leprae which are believed to influence morphology, configuration, number and
distribution of skin lesions.
Leprosy
;
Leprosy, Multibacillary
2.A randomized, double-blind, controlled study on the safety and efficacy of 25% Tinospora Rumphii (Makabuhay) cream versus 2% Mupirocin cream on superficial pyodermas caused by Staphylococcus aureus
Grace Monica Ibaviosa ; Johannes Dayrit ; Ma. Teresita G. Gabriel ; Gracia B. Teodosio ; Cara Lynn Chia
Journal of the Philippine Dermatological Society 2019;28(2):15-25
Background:
Superficial pyoderma is an infection most commonly caused by Staphyloccoccus aureus. The drug
of choice is 2% mupirocin cream. However, high cost and emerging drug resistance affect compliance and overall
cure. Tinospora rumphii has demonstrated antibacterial activity in vivo rendering it a potential cost-effective
alternative treatment.
Objectives:
To determine the safety and efficacy of 25% T. rumphii cream versus 2% mupirocin cream in the
treatment of superficial pyodermas caused by S. aureus.
Methods:
A randomized, double-blind, controlled study of 60 patients with superficial pyodermas caused by S
aureus, aged 18-60, were given either 25% T. rumphii or 2% mupirocin cream for two weeks. Bactericidal activity,
erythema, edema, induration and size of lesion were evaluated at baseline, days 3, 7, and 14. Participants Global
Assessment (PGA) score and adverse events were noted. Statistical analysis was done using Mann-Whitney U
and Pearson Chi square test. RESULTS: Fifty-one subjects (85%) completed the trial. There were no statistically
significant differences between the two treatment groups for bactericial activity against Staphylococcus aureus
(p=0.687) at day 14, for erythema (p=0.923, 0.5335, 0.3726, 0.6949), edema (p=0.0972, 0.5967, 0.2052, 0.2783),
induration (p=0.0855, 0.3113, 0.281, 0.3161), and size of lesions (p=0.7262, 0.169, 0.15, 0.3988) at baseline, days
3, 7 and 14. There was no significant difference in PGA score (p=0.3086, 0.3483, 0.2234) at Days 3, 7 and 14 in both
groups. No adverse events were noted.
Conclusion
Twenty five percent T. rumphii cream is equally safe and effective as 2% mupirocin cream for
treatment of superficial pyodermas caused by S. aureus.
Mupirocin
;
Staphylococcus aureus