1.Allopurinol: a necessary evil.
Singapore medical journal 2009;50(9):925-author reply 927
2.Carpal tunnel syndrome caused by tophaceous gout.
The Korean Journal of Internal Medicine 2014;29(4):544-545
3.A Case of Vanishing Bile Duct Syndrome Associated with Hypersensitivity to Allopurinol.
Seong Ho CHOI ; Soo Hyun YANG ; Young Bong SONG ; Hye Jin KIM ; Yeoung Tae SEO ; Dong Seog CHOI ; Kyoung Hyoub MOON ; Jong Hoon BYUN ; Eun Sil YU
The Korean Journal of Hepatology 2005;11(1):80-85
Allopurinol is frequently used for the treatment of hyperuricemia and gout. Sometimes, a life-threatening reaction develops, as is illustrated by the following case report. We describe a 60-year-old male patient who was treated with allopurinol because of asymptomatic hyperuricemia, and he was presented with fever, skin rash, eosinophilia, worsening renal function and vanishing bile duct syndrome. In this report, we discussed vanishing bile duct syndrome as a serious side effect of allopurinol, and we briefly reviewed the etiology, prevention, and treatment modalities for vanishing bile duct syndrome.
Allopurinol/*adverse effects
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Bile Duct Diseases/*etiology/pathology
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Drug Hypersensitivity/*complications
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English Abstract
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Gout Suppressants/*adverse effects
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Humans
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Male
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Middle Aged
4.Allopurinol hypersensitivity syndrome in patients with hematological malignancies: characteristics and clinical outcomes.
Hong Ki MIN ; Boin LEE ; Seung Ki KWOK ; Ji Hyeon JU ; Wan Uk KIM ; Young Min PARK ; Sung Hwan PARK
The Korean Journal of Internal Medicine 2015;30(4):521-530
BACKGROUND/AIMS: Allopurinol is a urate-lowering agent that is commonly used to prevent chemotherapy-related hyperuricemia. Allopurinol hypersensitivity syndrome (AHS) is a disorder involving multiple organs, which may be accompanied by cutaneous adverse reactions. We identified the characteristics and clinical outcomes of chemotherapy-associated AHS in patients with hematological malignancies. METHODS: This retrospective single-center study included 26 AHS patients (11 with and 15 without hematological malignancies) admitted to Seoul St. Mary's Hospital. AHS was defined using the criteria of Singer and Wallace. Comparisons were made using the Mann-Whitney U test and Fisher exact test as appropriate. RESULTS: In patients with a hematological malignancy and AHS, statistically significant differences were observed in terms of younger age at onset; shorter duration of exposure; higher starting and maintenance doses of allopurinol; lower incidence of eosinophilia, leukocytosis, and underlying renal insufficiency; and more frequent occurrence of fever compared to AHS patients without a hematological malignancy. Two AHS patients with a hematological malignancy were examined for human leukocyte antigen (HLA)-B typing, but neither patient harbored the HLA-B*5801 allele. All of the patients ceased allopurinol treatment, with most patients making a full recovery. Two patients in the study died; however, these deaths were unrelated to AHS. One patient developed serious sequelae of AHS that required hemodialysis. CONCLUSIONS: Physicians who prescribe allopurinol for the prevention of chemotherapy-related hyperuricemia should be aware of the unique risk of AHS, even in patients with hematological malignancies who do not have known risk factors for AHS. Novel urate-lowering agents should be considered alternative treatments.
Adolescent
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Adult
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Age Factors
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Aged
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Allopurinol/*adverse effects
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Antineoplastic Agents/*adverse effects
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Comorbidity
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Dose-Response Relationship, Drug
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Drug Hypersensitivity Syndrome/diagnosis/drug therapy/*etiology
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Female
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Glucocorticoids/therapeutic use
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Gout Suppressants/*adverse effects
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Hematologic Neoplasms/*drug therapy
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Humans
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Hyperuricemia/chemically induced/diagnosis/*prevention & control
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Male
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Medical Records
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Middle Aged
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Republic of Korea
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Retrospective Studies
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Risk Factors
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Treatment Outcome
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Young Adult