1.Reversible Dysphasia and Statins.
Journal of Korean Medical Science 2012;27(4):458-459
This paper presents a case of reversible dysphasia occurring in a patient prescribed atorvastatin in combination with indapamide. A milder dysphasia recurred with the prescription of rosuvastatin and was documented on clinical examination. This resolved following cessation of rosuvastatin. The case highlights both a need for a wider understanding of potential drug interactions through the CYP 450 system and for an increased awareness, questioning and reporting of drug side-effects.
Anticholesteremic Agents/adverse effects/*therapeutic use
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Antihypertensive Agents/therapeutic use
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Anxiety/diagnosis
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Aphasia/diagnosis/*etiology
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Cytochrome P-450 Enzyme System/metabolism
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Depression/diagnosis
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Drug Interactions
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Female
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Fluorobenzenes/adverse effects/*therapeutic use
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Heptanoic Acids/adverse effects/*therapeutic use
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Humans
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Hypercholesterolemia/drug therapy
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Indapamide/therapeutic use
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Middle Aged
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Pyrimidines/adverse effects/*therapeutic use
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Pyrroles/adverse effects/*therapeutic use
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Sulfonamides/adverse effects/*therapeutic use