1.Enteric Fever with Bowel Perforation Caused by Nontyphoidal Group D Salmonella.
Jin Ho LEE ; Jin Gook HUH ; Jong Chun NAH ; Eu Suk KIM ; Hye Kyung LEE ; Bo Moon SHIN ; Shukho KIM ; Haengil KOH
Infection and Chemotherapy 2004;36(4):251-254
The case of enteric fever and bowel perforation caused by nontyphoidal Salmonella spp. is extremely rare. We report a case of a 28-year-old man who suffered from enteric fever with complicated a small bowel perforation, which is a known complication of S. typhi and S. paratyphi infections. The culprit later proved to be nontyphoidal group D Salmonella spp. in our case.
Adult
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Humans
;
Salmonella*
;
Typhoid Fever*
2.Enteric Fever with Bowel Perforation Caused by Nontyphoidal Group D Salmonella.
Jin Ho LEE ; Jin Gook HUH ; Jong Chun NAH ; Eu Suk KIM ; Hye Kyung LEE ; Bo Moon SHIN ; Shukho KIM ; Haengil KOH
Infection and Chemotherapy 2004;36(4):251-254
The case of enteric fever and bowel perforation caused by nontyphoidal Salmonella spp. is extremely rare. We report a case of a 28-year-old man who suffered from enteric fever with complicated a small bowel perforation, which is a known complication of S. typhi and S. paratyphi infections. The culprit later proved to be nontyphoidal group D Salmonella spp. in our case.
Adult
;
Humans
;
Salmonella*
;
Typhoid Fever*
3.Cap-independent protein translation is initially responsible for 4-(N-methylnitrosamino)-1-(3-pyridyl)-butanone (NNK)-induced apoptosis in normal human bronchial pithelial cells.
Seo Hyun MOON ; Hyun Woo KIM ; Jun Sung KIM ; Jin Hong PARK ; Hwa KIM ; Gook Jong EU ; Hyun Sun CHO ; Ga Mi KANG ; Kee Ho LEE ; Myung Haing CHO
Journal of Veterinary Science 2004;5(4):369-378
Evidences show that eukaryotic mRNAs can perform protein translation through internal ribosome entry sites (IRES). 5'-Untranslated region of the mRNA encoding apoptotic protease-activating factor 1 (Apaf-1) contains IRES, and, thus, can be translated in a cap-independent manner. Effects of changes in protein translation pattern through rapamycin pretreatment on 4-(methylnitrosamino)-1-(3-pyridyl)-butanone(NNK, tobacco-specific lung carcinogen)-induced apoptosis in human bronchial epithelial cells were examined by caspase assay, FACS analysis, Western blotting, and transient transfection. Results showed that NNK induced apoptosis in concentration- and time-dependent manners. NNK-induced apoptosis occurred initially through cap-independent protein translation, which during later stage was replaced by cap-dependent protein translation. Our data may be pplicable as the mechanical basis of lung cancer treatment.
Antibiotics, Antineoplastic/pharmacology
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Apoptosis/*drug effects
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Apoptotic Protease-Activating Factor 1
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BH3 Interacting Domain Death Agonist Protein
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Blotting, Western
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Bronchi/metabolism/*pathology
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Carcinogens/*pharmacology
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Carrier Proteins/metabolism
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Caspases/metabolism
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Cytochromes c/metabolism
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Dose-Response Relationship, Drug
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Epithelial Cells/metabolism/*pathology
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Eukaryotic Initiation Factor-4E/metabolism
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Flow Cytometry
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Humans
;
Nitrosamines/*pharmacology
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Protein Biosynthesis
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Proteins/metabolism
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Proto-Oncogene Proteins c-bcl-2/metabolism
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RNA Cap-Binding Proteins/*physiology
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Sirolimus/pharmacology
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Time Factors
;
bcl-2-Associated X Protein