Objective To evaluate the effect on schistosomiasis control by implementing the synthetic measures with emphasis on infection source control.Methods Ten higher endemic villages in 10 counties were chosen to implement the measures of " replacing cattle with machines", "rearing domestic animals in pens", "safely treating night-soil or building methane-generating pits".In these villages, all cattle should be eliminated, other livestock be reared in pens, and all households be supplied with sanitary lavatories that could safely treat night-soil, or with methane-generating pits, and safe water. Results After 1 year of implementing the project, the number of cattle, sheep, pigs and dogs in 10 villages reduced by 92.7%,70.8%,14.3% and 20.2%, respectively, 76.0% of households had sanitary lavatories or methane-generating pits, 75.9% of households had safe water supply, all the remaining pigs were reared in pens, and the schistosome infection rate of residents reduced by 75.8%, the infection rate of cattle reduced by 79.8%, the density of infected snails reduced by 75.0% and the infection rate of snails reduced by 60.0%, respectively. Conclusion The synthetic measures with emphasis on infection source control are effective in schistosomiasis control.

BACKGROUND:N6-methyladenosine(m6A)is a hot research topic in the mechanism of pathological cardiac remodeling and plays an important role in the development of cardiovascular diseases. OBJECTIVE:To summarize the possible mechanism by which m6A modification in non-coding RNAs regulates the main processes of pathological cardiac remodeling,such as pathological cardiac hypertrophy,cardiomyocyte death,myocardial fibrosis and vascular remodeling. METHODS:"m6A,non-coding RNA,pathological cardiac hypertrophy,cardiomyocyte apoptosis,cardiomyocyte pyroptosis,cardiomyocyte ferroptosis,myocardial fibrosis,vascular remodeling"were used as search terms in Chinese and English.Relevant literature from CNKI,PubMed and Web of Science databases published from January 1974 to April 2023 was retrieved,and finally 86 eligible articles were reviewed. RESULTS AND CONCLUSION:m6A modification is a highly dynamic and reversible modification.Pathological cardiac remodeling mainly involves pathological cardiac hypertrophy,cardiomyocyte apoptosis,cardiomyocyte pyroptosis,cardiomyocyte ferroptosis,myocardial fibrosis and vascular remodeling.m6A-related enzymes can regulate pathological cardiac remodeling processes through various non-coding RNAs and different signaling pathways,which can be used as a new potential intervention for cardiovascular diseases.In pathological cardiac remodeling,research on the regulatory relationship between m6A modification and non-coding RNAs is still in its infancy.With the development of epigenetics,m6A modification in non-coding RNAs is expected to have a new development in the regulation of pathological cardiac remodeling.