This paper presents the situation of secrecy management at colleges and universities,and analyzes the reasons for the inadequacy of capability in this aspect.From the perspective of PAEI management roles,we point out the solutions to improve the capability include strengthening leaderships,targeting,building system,managing risks and raising awareness of secrecy.

Background and purpose:Aurora-A is a member of serine/threonine kinase family. The abnormal expression of Aurora-A induces tumorigenesis and radioresistance. This study was aimed to investigate the association of Aurora-A with radioresistance. Methods: Capan-1 cells were treated with Aurora-A kinase inhibitor, and then used to test cell proliferation, anchorage independent assay, cell cycle, and cell cycle regulatory proteins. Treated cells were also used to detect cell apoptosis afterγ-irradiation. Results:Cell growth and colony number in soft agar were decreased after treatment with Aurora-A inhibitor. Treatment of cells with Aurora-A inhibitor also down-regulated the expression of Cyclin D1, CDK2 and CDK6 to induce cell cycle arrest at G1/S and G2/M phases, but promoted cell apoptosis afterγ-irradiation. Conclusion:Treatment of pancreatic cancer cells with Aurora-A kinase inhibitor blocks cell proliferation and cell cycle progression, and promotes sensitivity of cells to radiation. Thus, Aurora-A may be used as one of therapeutic targets to increase the sensitivity of pancreatic cancer radiotherapy.

Objective To explore some features of the sonographic appearance of recurrent and revival pheochromoeytoma (PHEO) in order to get some references in the clinical diagnosis.Methods To compare sonograms of 10 patients with recurrent and revival PHEO with sonograms of 60 cases(contrast group)with unrecurrent and unrevival PHEO in the same period.Results There was significant difference between the two groups and contrast group(G=9.475,P=0.002).However there was no significance in the incidence of malignant PHEO between recurrent and revival one(P>0.05).The echo of tumor:complex echo 2 cases,purely solid hypoecho 5 cases and hffperecho 1 case.Conclusions The tumor with recurrent and revival PHEO could have potential malignancy,the PHEO at the extra-adrenal often showed a phenomenon of recurrence,and the malignant PHEO appeared the multiple character.

China ; Female ; Humans ; Male ; Population Surveillance ; Tobacco Use Cessation ; methods ; Tobacco Use Disorder ; epidemiology ; prevention & control ; World Health Organization

As a major venue of scientific research activities,medical colleges and institutes are also an importance source of providing highly trained medical talents.With the medical education reform deepen,scientific research is now becoming the focus point of exploring the social aspect of medicine.Taking one military medical university as example,this paper demonstrated four specific measures for managing social sciences research in medical colleges.

Object To investigate the synthesis of alkaloids by cell suspension cultures of Datura metel L. Methods Cultured cells derived from leaves of D. metel were m aintained in Murashige and Skoog (MS) liquid medium. The effects of different c arbohydrated, different inoculum sizes, and different pH values of medium as aff ecting facters on cell growth and alkaloid formation were studied. Re sults The optimum carbohydrate was sucrose, inoculum size (1.5 - 2. 0 g/L) for fresh weight and initial pH values (5.5-6.0) of the medium were benefit for cell growth and alkaloid synthesis in the suspension cultures. The synthesis of alk aloids was improved when exogenous phenylalanine added to the culture. Conclusion Suspension-cultured cells of D. metel c an be used to synthesize alkaloids.

With the expanding of ultrasonic applications, the development of ultrasonic surgical equipment has become a focus in related fields. Ultrasonic horn system is an important component of surgical equipment,and the horn resonance properties directly affect the technical performance of ultrasonic surgical equipment. In this paper, a number of tuning and matching methods appeared in recent years are discussed, and the advantages and problems are analyzed. On the basis, foreground of the research is prospected.

Objective To summarize the clinical features of severe fever with thrombocytopenia syndrome(SFTS),to improve the understanding of the disease,and strengthen the prevention and treatment of the disease,thus to improve the survival rate.Methods To analyze the patients with SFTS in our hospital,including their clinical characteristics and treatment methods.Results Of 210 patients,115 cases were mild,95 cases were heavy cases.191 cases were cured and discharged,among them,115 cases were mild,and the others were severe in all cases.The total effective rate was 90.95%,with a total mortality of 19 cases,with a fatality rate of 9.04%.Conclusion SFTS mainly manifested as fever,fatigue,nausea,vomiting,diarrhea.The treatment is mainly symptomatic treatment of early cases can not be identified,can be added with doxycycline.Those have basic disease and poor prognosis often have severe syndromes.White blood cell,platelet count and lactate dehydrogenase are related to the prognosis of the disease.

Objective To study the CT features and enhance the knowledge of peripheral primitive neuroectodermal tumors(pPNETs). Methods The CT appearances of 6 patients with pPNETs pathologically proved were analyzed retrospectively. Results The CT findings of 5 bone pPNETs were soft mass of homogeneous or heterogeneous density and osteolytic destruction without osteosclerosis, periosteum reaction and tumor bone formation. Follow up CT showed the mass shrunken significantly after radiotherapy in one case. In 1 patient of chest Askin tumor, the lesion appeared as a vast heterogeneous soft mass with moderate inhomogeneous enhancement. The mass invaded mediastinum and local bone destruction were not detected. Four months after operation, a small homogeneous tumor occurred in right chest wall with moderate homogeneous enhancement. Conclusion The manifestations of pPNETs on CT have no characteristics. However, CT can show the intra tumor structures and the extent of the tumor very well, which is helpful in differentiating diagnosis,predicting resectability, detecting distant metastases and evaluating the response to treatment.

This article aims to promote the teaching quality in clinical pharmachology. The methods are as follows: First, understanding the difference between the clinical pharmachology and pharmachology; Second, improving the teachers’ teaching level, especially increasing the clinical experiences in using drug; Third, developing the teachers’ spirits of occupation; Last, cultivating the ability of self-teaching of students.