1.Study on the role of sex steroid hormones playing in the control of rat ovarian tumor growth.
Jin Gook CHOI ; Kyu Sub LEE ; Sang NA ; Yong Jin NA ; Won Whe KIM
Korean Journal of Obstetrics and Gynecology 1993;36(7):2645-2651
No abstract available.
Animals
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Gonadal Steroid Hormones*
;
Rats*
2.Effects of sex hormones on the induction of glutathione S-transferase-P positive hyperplastic hepatic nodules in rats.
Sang Jeon LEE ; Soo Tae KIM ; Sang Chul PARK ; Kye Yong SONG
Journal of the Korean Cancer Association 1991;23(4):708-722
No abstract available.
Animals
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Glutathione*
;
Gonadal Steroid Hormones*
;
Rats*
3.Hormonal and growth effects of GnRH analogue and gonadal steroid hormones on gynecological tumor cell lines.
Jin Woo KIM ; Sa Jin KIM ; Ki Sung RYU ; Gu Taek HAN ; Jae Keun JUNG ; Sung Eun NAMKOONG ; Seung Jo KIM ; Hun Young LEE
Korean Journal of Obstetrics and Gynecology 1992;35(11):1649-1660
No abstract available.
Cell Line, Tumor*
;
Gonadal Steroid Hormones*
;
Gonadotropin-Releasing Hormone*
;
Gonads*
4.What Should Be Considered in Treatment of Melasma.
Hee Young KANG ; Jean Paul ORTONNE
Annals of Dermatology 2010;22(4):373-378
Melasma is a common acquired hyperpigmentary skin disorder characterized by light to dark brown macules and patches occurring in the sun-exposed areas of the face. Melasma lesional skin is characterized by epidermal hyperpigmentation through increased melanogenesis in epidermal melanocytes. Some patients have dermal melanin but its amount is not significant and its distribution is very heterogeneous in the whole melasma lesional skin. Melasma is not homogeneous disease and there are personal characteristics of patients with melasma. The pathogenesis of melasma is not fully understood, but several hypotheses have been suggested. Increased vascularity in melasma lesions has suggested the role of increased number of enlarged vessels in the development of melasma. Endogeneous and exogeneous stimuli such as sex hormones and ultraviolet irradiation respectively may stimulate the microenvironment leading to the release of various mediators that cause activation of melanocytes and/or these stimuli may directly activate the melanocytes. Melasma patients may have specialized melanocytes with an intrinsic sensitivity to these stimuli.
Gonadal Steroid Hormones
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Humans
;
Hyperpigmentation
;
Light
;
Melanins
;
Melanocytes
;
Melanosis
;
Skin
5.Effect of Occupational Lead on Male Sex Hormones.
Hyeong Su KIM ; Soung Hoon CHANG ; Won Jin LEE ; Jae Wook CHOI ; Jong Tae PARK ; Nam Won PAIK ; Rok Ho KIM
Korean Journal of Occupational and Environmental Medicine 2001;13(1):44-54
OBJECTIVES: This study was performed to evaluate the relationship between biological markers of lead exposure and level of sex hormones in men occupationally exposed to lead. METHODS: In this study, 33 male workers who employed at smelting and battery factories were compared with 33 male workers who were not exposed to lead. As biological markers of lead exposure, hemoglobin, ZPP, blood lead and urine lead were measured. As sex hormones, FSH, LH, testosterone, SHBG and FTI were determined. RESULTS: Hemoglobin level was significantly lower in exposed than in nonexposed group. Level of ZPP, blood lead, and urine lead were significantly higher in exposed than in nonexposed group. There was a trend that level of FSH, testosterone, SHBG, and FTI was lower in exposed than in nonexposed group respectively, but there were no statistical significance. In exposed group, FSH level was correlated with age, ZPP, and blood lead; testosterone level was correlated with hemoglobin, blood lead, urine lead, and SHBG; and FTI level was correlated with age. CONCLUSIONS: Level of some sex hormones were lower in exposed than in nonexposed group but there were no statistical significance between the exposed and the nonexposed group. But level of sex hormones were correlated with several biological markers of lead in exposed group. It suggests that occupational lead exposure might affect sex hormones.
Biological Markers
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Gonadal Steroid Hormones*
;
Humans
;
Male*
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Occupations
;
Osmeriformes
;
Testosterone
6.Sex hormones among Workers Exposed to Pesticides.
Wonjin LEE ; Cheong Sik KIM ; Hyeong Su KIM ; Chang Hoon LEE ; Jin Seok KIM
Korean Journal of Occupational and Environmental Medicine 2000;12(2):179-186
OBJECTIVE: This study was carried out to determine the effects of occupational pesticides exposure on the level of serum Luteinizing Hormone(LH), Follicle Stimulating Hormone(FSH), testosterone in male workers. METHODS: Twenty-two male workers exposed to pesticides were compared with twenty-eight male workers at same factory who were not exposed to pesticides. The selected variables for studying reproductive hormones were LH, FSH and testosterone. As part of the baseline health status, subjects were asked medical history. RESULTS: There were no statistically significant differences on the level of LH, FSH, testosterone between the exposed and non-exposed group. Also the level of sex hormones were not significant difference with each department in exposed group. And the level of LH, FSH positively correlated with age. CONCLUSIONS: These results indicate that there are no alterations in LH, FSH, testosterone at workers exposed to pesticides. But our findings are highly preliminary because of a small sample size. Thus it calls for furthur investigation of the hormonal effects at workers exposed to pesticides.
Gonadal Steroid Hormones*
;
Humans
;
Lutein
;
Male
;
Pesticides*
;
Sample Size
;
Testosterone
7.Change of Second to Fourth Digit Ratio according to Age in Korean Children.
Korean Journal of Physical Anthropology 2015;28(4):197-203
The 2nd to 4th digit ratio (2D : 4D) reflects exposure level of sex hormones in fetal period. The aim of this study is to identify a change of digit ratio according to age and a critical age showing gender difference in Korean children. This study was done on 1,182 children (588 males, 594 females). Data were collected by measuring index and ring finger length on both hands by photocopy. The data were analyzed using SPSS win 21.0. This study showed that the 2nd and 4th finger length and digit ratio of both hands increased with age both male and female. There was no differences in 2nd to 4th digit ratio between males and females until they were 3 years old. However, there were significant differences in 2nd to 4th digit ratio between males and females from the age of four. The results suggest that digit ratio in Korean children increases with age and a critical age showing gender difference is from the age of four.
Child*
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Female
;
Fingers
;
Gonadal Steroid Hormones
;
Hand
;
Humans
;
Male
8.Sexual hormone and sperm cytological test in patients with aspermia.
Qu-Tao ZHANG ; Jian-Feng CHANG ; Yi-Feng GE
National Journal of Andrology 2002;8(3):207-209
OBJECTIVESTo test the serum sexual hormone and sperm cytology in aspermia patients.
METHODSRadioimmunoassay (RIA) and Wright-Giemsa stain were used to detect serum sexual hormone and sperm cytology in 45 aspermia patients.
RESULTSAmong the 45 patients, spermatogenetic cells were detected in 16 patients(35.6%). The level of serum testerone were decreased in 16 patients, and FSH, LH were increased in 13 cases as well as that of PRL in 4 cases.
CONCLUSIONSThese results suggested that the testis function was demaged, the ratio of T/LH could further reflect the function of Leydig cells, the detection of PRL were significant only in diagnosis of aspermia induced by hypermia. It is an important index in identifying obstructive and non-obstructive aspermia and has important significance in estimating the extention of testis demage and commanding the clinical treatment of serum hormone detection and sperm cell analysis.
Gonadal Steroid Hormones ; metabolism ; Humans ; Male ; Oligospermia ; metabolism ; pathology ; Spermatogenesis
9.The effects of liver disease on endocrine hormone.
Mengyuan YANG ; Bing LI ; Huiguo DING
Chinese Journal of Hepatology 2014;22(3):168-170
10.Thyroid Dysfunction Associated with Administration of the Long-Acting Gonadotropin-Releasing Hormone Agonist.
Eun Jin HAN ; Ha Do SONG ; Ji Hoon YANG ; So Young PARK ; Sung Hoon KIM ; Hyun Koo YOON ; Chang Hoon YIM
Endocrinology and Metabolism 2013;28(3):221-225
Gonadotropin-releasing hormone (GnRH) agonist has been used in the treatment of a wide variety of sex-hormone-related diseases, as the administration of GnRH agonist can alter the secretion of gonadotropin and sex hormones. Recently, we found that the long-acting GnRH agonist aggravated hyperthyroidism and induced painless thyroiditis. This is the first report to demonstrate the association of thyroid dysfunction with GnRH agonist injection in Korea. Here, we report three cases and emphasize the clinical importance of this aggravating factor in autoimmune thyroid disease.
Gonadal Steroid Hormones
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Gonadotropin-Releasing Hormone
;
Gonadotropins
;
Graves Disease
;
Hyperthyroidism
;
Korea
;
Thyroid Diseases
;
Thyroid Gland
;
Thyroiditis