Objective To investigate the relationship between cerebral thrombosis and iron-deficiency anemia, and their clinical manifestations and therapy. Methods The clinical data of 4 patients with iron deficiency anemia complicated by cerebral thrombosis were analyzed retrospectively. Results Four patients were moderate-to-sexere anemia with thrombocytosis, and their blood pressure was relatively low. Two had chronic infection foci. All patients had cerebral infarction in the internal carotid system, of those, 2 were weatershed infarctions, and 2 were basal ganglia infarctions. Oxygen inhalation, correcting anemia, adjusting blood presssure to an appropriate level, and other conventional treatment were effective. Conclusions The patients with moderate-to-severe anemia, such as accompanied by thrombocytosis and lower blood pressure, are easy to came thrombosis. While in the routine treatment of cerebral thrombosis, attention should be paid to finding the causes of anemia and correcting them.