1.Recurrent Episodes of Rhabdomyolysis after Seizures in a Patient with Glycogen Storage Disease Type V.
Hyung Jun PARK ; Yoonkyung CHANG ; Jee Eun LEE ; Heasoo KOO ; Jeeyoung OH ; Young Chul CHOI ; Kee Duk PARK
Journal of Clinical Neurology 2016;12(3):373-375
No abstract available.
Glycogen Storage Disease Type V*
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Glycogen Storage Disease*
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Glycogen*
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Humans
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Rhabdomyolysis*
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Seizures*
2.A Case of McArdle's Disease.
Sang Ik LEE ; Chang Won SONG ; Kyu Hyun PARK ; Sang Wook KIM
Journal of the Korean Neurological Association 1992;10(4):554-558
McArdle's disease is a disorder of carbohydrate metabolism, which is inhented as an autosomal recessive or occasionally an autosomal dominant trait. Hallmark of clinical features is exercise intolerence, I.e. muscle pain following strenuous exercise. Electrophysiologically insertion of an EMG needle shows that there is no electrical activity, differentiating this contracture from a muscle cramp. Histological examination of muscle biopsy specimen shows increase in glycogen and the presence of subsarcolemrnal blebs. We report a 23-year-old, male patient who presented clinical, electrophysiological, and histological findings compatible with McArdle's disease.
Biopsy
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Blister
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Carbohydrate Metabolism
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Contracture
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Glycogen
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Glycogen Storage Disease Type V*
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Humans
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Male
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Muscle Cramp
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Myalgia
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Needles
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Young Adult
3.The Significance of Clinical and Laboratory Features in the Diagnosis of Glycogen Storage Disease Type V: A Case Report.
Hyung Jun PARK ; Ha Young SHIN ; Yu Na CHO ; Seung Min KIM ; Young Chul CHOI
Journal of Korean Medical Science 2014;29(7):1021-1024
Glycogen storage disease type V (GSD-V) is the most common disorder of muscle glycogenosis with characteristic clinical and laboratory findings. A 32-yr-old woman complained of exercise intolerance and myoglobulinuria since early adolescence. She reported several episodes of second-wind phenomenon. Physical examination did not show any neurological abnormality, including fixed muscle weakness or atrophy. Serum creatine kinase level was 1,161 IU/L at rest. The result of the non-ischemic forearm exercise test was compatible with GSD-V. Mutation analysis identified the compound heterozygous mutations of the PYGM, p.D510fs and p.F710del, which has not yet been reported in Korea. The present case recognizes that detail clinical and laboratory analysis is the first step in the diagnosis of GSD-V.
Adult
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Base Sequence
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Creatine Kinase/blood
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Exons
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Female
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Frameshift Mutation
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Gene Deletion
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Genotype
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Glycogen Phosphorylase, Muscle Form/genetics
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Glycogen Storage Disease Type V/*diagnosis/genetics/pathology
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Humans
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Pedigree
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Sequence Analysis, DNA