1.Changes of Regional Cerebral Glucose Metabolism in Normal Aging Process ; A Study With FDG PKT.
Joon Kee YOON ; Sang Eun KIM ; Kyung Han LEE ; Yong CHOI ; Yearn Seong CHOE ; Byung Tae KIM
Korean Journal of Nuclear Medicine 2001;35(4):231-240
No abstract available.
Aging*
;
Glucose*
;
Metabolism*
2.Pattern of Cerebral Glucose Metabolism on F - 18 FDG Brain PET druing Vomiting and Symptom Free Periods in Cyclic Vomiting Syndrome.
Yu Kyeong KIM ; Dong Soo LEE ; Eun Joo KANG ; Jeong Kee SEO ; Jeong Seok YEO ; June Key CHUNG ; Myung Chul LEE
Korean Journal of Nuclear Medicine 2001;35(3):198-204
No abstract available.
Brain*
;
Glucose*
;
Metabolism*
;
Vomiting*
3.Optimization of UDP-glucose supply module and production of ginsenoside F1 in Saccharomyces cerevisiae.
Jin-He WANG ; Dong WANG ; Wei-Xian LI ; Ying HUANG ; Zhu-Bo DAI ; Xue-Li ZHANG
China Journal of Chinese Materia Medica 2019;44(21):4596-4604
Ginsenoside F1 is a rare ginsenoside in medicinal plants such as Panax ginseng,P. notogingseng and P. quinquefolius. It has strong pharmacological activities of anti-tumor,anti-oxidation and anti-aging. In order to directly produce ginsenoside F1 by using inexpensive raw materials such as glucose,we integrated the codon-optimized P.ginseng dammarenediol-Ⅱ synthase(Syn Pg DDS),P.ginseng protopanaxadiol synthase(Syn Pg PPDS),P. ginseng protopanaxatriol synthase(Syn Pg PPTS) genes and Arabidopsis thaliana cytochrome P450 reductase(At CPR1) gene into triterpene chassis strain BY-T3. The transformant BY-PPT can produce protopanaxatriol. Then we integrated the Sacchromyces cerevisiae phosphoglucomutase 1(PGM1),phosphoglucomutase 2(PGM2) and UDP-glucose pyrophosphorylase 1(UGP1) genes into chassis strain BY-PPT. The UDP-glucose supply module increased UDP-glucose production by 8. 65 times and eventually reached to 44. 30 mg·L-1 while confirmed in the transformant BY-PPT-GM. Next,we integrated the UDPglucosyltransferase Pg3-29 gene which can catalyze protopanaxatriol to produce ginsenoside F1 into chassis strain BY-PPT-GM. The transformant BY-F1 produced a small amount of ginsenoside F1 which was measured as 0. 5 mg·L-1. After the fermentation process was optimized,the titer of ginsenoside F1 could be increased by 900 times to 450. 5 mg·L-1. The high-efficiency UDP-glucose supply module in this study can provide reference for the construction of cell factories for production of saponin,and provide an important basis for further obtaining high-yield ginsenoside yeast cells.
Ginsenosides/metabolism*
;
Glucose
;
Panax
;
Saccharomyces cerevisiae/metabolism*
;
Uridine Diphosphate Glucose
4.The Impaired Glucose Metabolism in Patients with Cushing's Syndrome.
Hyung Joo PARK ; Joong Yeol PARK
Journal of Korean Society of Endocrinology 2003;18(4):356-359
No abstract available.
Cushing Syndrome*
;
Glucose*
;
Humans
;
Metabolism*
5.Regulation of Leptin and Resistin Gene Expression:Roles in Food Intake and Glucose Metabolism.
Journal of Korean Society of Pediatric Endocrinology 2001;6(2):104-106
No abstract available.
Eating*
;
Glucose*
;
Leptin*
;
Metabolism*
;
Resistin*
6.A study on Glucose Metabolism in Newborn Infants.
Keun Chul MYUNG ; Chang Soo RA
Journal of the Korean Pediatric Society 1985;28(12):1167-1176
No abstract available.
Glucose*
;
Humans
;
Infant, Newborn*
;
Metabolism*
7.Research progress on the role of glucose in regulating immune homeostasis.
Hui Yi CHEN ; Hai Li WU ; Hui WANG ; Xiao Guang LI
Chinese Journal of Preventive Medicine 2023;57(11):1882-1887
Glucose is the central nutrient for energy metabolism and life support in the human body. As the main energy substance of the body, glucose is essential for the normal function of immune cells and their proliferation; when glucose homeostasis is disrupted in the body, it may lead to impaired immune system function and pathological conditions. Exploring the relationship between glucose metabolism and immune regulation can help establish the gene regulatory network and figure out potential pathogenic mechanisms under physiological and pathological conditions. This article reviews the current scientific research progress on glucose metabolism and immunity, mainly focusing on the physiological regulatory functions of glucose in maintaining the homeostasis of innate and acquired immunity; and summarizes the research progress on the effects and mechanisms of glucose on tumor immunity and its related therapies under pathological conditions, taking tumors as an example.
Humans
;
Glucose/metabolism*
;
Homeostasis/physiology*
8.Research progress on the role of glucose in regulating immune homeostasis.
Hui Yi CHEN ; Hai Li WU ; Hui WANG ; Xiao Guang LI
Chinese Journal of Preventive Medicine 2023;57(11):1882-1887
Glucose is the central nutrient for energy metabolism and life support in the human body. As the main energy substance of the body, glucose is essential for the normal function of immune cells and their proliferation; when glucose homeostasis is disrupted in the body, it may lead to impaired immune system function and pathological conditions. Exploring the relationship between glucose metabolism and immune regulation can help establish the gene regulatory network and figure out potential pathogenic mechanisms under physiological and pathological conditions. This article reviews the current scientific research progress on glucose metabolism and immunity, mainly focusing on the physiological regulatory functions of glucose in maintaining the homeostasis of innate and acquired immunity; and summarizes the research progress on the effects and mechanisms of glucose on tumor immunity and its related therapies under pathological conditions, taking tumors as an example.
Humans
;
Glucose/metabolism*
;
Homeostasis/physiology*
9.Developmental trend analysis and perspectives on researches related to hepatic glucose and lipid metabolism.
Lei SHI ; Hua QU ; Hong-Ting ZHENG ; Xiu-Jie WANG
Acta Physiologica Sinica 2021;73(5):781-794
The balance of glucose and lipid metabolism is a coordinated result of multiple factors and organs, and is one of the fundamental requirements for the maintenance of human health. As the most important organ for human metabolism, liver plays a key role in regulating glucose and lipid metabolism. With the advances of researches, the number of publications related to hepatic glucose and lipid metabolism has increased rapidly, which posed a challenge for grasping the hot research topics and developmental trends of hepatic glucose and lipid metabolism in a short time. To solve such problem, we developed an information analysis method, which systematically analyzes the research status, research techniques, and hot research topics of the hepatic glucose and lipid metabolism research field through Medical Subject Headings (MeSH) of related papers and high-throughput experimental data. The results showed that the number of publications related to hepatic glucose and lipid metabolism, especially publications by Chinese scholars, has increased dramatically in this century, along with the remarkable increment of the numbers of authors and affiliations per paper. Such increment is in part positively correlated with the impact of publications. Nowadays, various types of high-throughput experimental techniques have become the main research methods for genetic studies of hepatic glucose and lipid metabolism. Transcription factors, such as peroxisome proliferator-activated receptors (PPARs), sterol regulatory element binding proteins (SREBPs), and NF-E2-related factor 2 (Nrf2), have become the new research hotspots. These results systematically showed the current focuses and developmental trends of hepatic glucose and lipid metabolism research, and the data analysis method developed in this work can also be applied to other research fields.
Glucose/metabolism*
;
Humans
;
Lipid Metabolism
;
Liver
10.Propionic acid fermentation by Propionibacterium freudenreichii CCTCC M207015 with a fibrous-bed bioreactor.
Xiaohai FENG ; Bo WU ; Xiaobo SHEN ; Hong XU
Chinese Journal of Biotechnology 2008;24(6):1075-1079
The production of propionic acid by Propionibacterium freudenreichii CCTCC M207015 was investigated in a Fibrous-bed bioreactor (FBB). The FBB was constructed by packing spiral cotton fibrous and immobilized into a bioreactor. By applying this bioreactor to propionic acid fermentation, the propionic acid yield had a significant improvement and reached 20.41 g/L, compared with the cell-free culture of 14.58 g/L (40 g/L of glucose). At the same time, the glucose exhausting time decreased from 120 h to 60 h. Batch fermentations at various glucose concentrations were carried out with FBB. Based on the analysis of the time course of production, fed-batch fermentation was also applied to produce propionic acid with FBB, the maximal propionic acid yield reached 45.91 g/L, and the proportion of propionic acid to total acids was about 72.31%.
Bioreactors
;
microbiology
;
Fermentation
;
Glucose
;
metabolism
;
Propionates
;
metabolism
;
Propionibacterium
;
classification
;
metabolism