No abstract available.
Glomerulosclerosis, Focal Segmental*

Minimal Change Disease (MCD) and Focal Segmental Glomerulosclerosis (FSGS) are common causes of nephrotic syndrome. These two conditions are similar in their presentations but differentiated via their histopathological features and responsiveness to corticosteroids. There are ongoing debates whether MCD and FSGS are at the same spectrum of disease rather than separate entities. FSGS has been postulated to be the severe end of the spectrum of MCD. We have reported a case that has primary FSGS after years of poorly controlled MCD, which supports both conditions are the same spectrum of disease.
Focal segmental glomerulosclerosis

No abstract available.
Glomerulosclerosis, Focal Segmental* ; Hyperlipidemias* ; Hyperlipoproteinemias* ; Nephrotic Syndrome*

No abstract available.
Glomerulonephritis ; Glomerulosclerosis, Focal Segmental* ; Humans ; Kidney

No abstract available.
Glomerulosclerosis, Focal Segmental* ; Polycystic Kidney Diseases*

No abstract available.
Animals ; Glomerulosclerosis, Focal Segmental* ; Lovastatin* ; Puromycin* ; Rats*

Renal involvement is one of the extra-articular manifestations found in patients with rheumatoid arthritis (RA). Membranous glomerulonephopathy, membranoproliferative glomeruonophritis, secondary amyloidosis, and focal segmental glomerulosclerosis are reported as pathologic diagnoses of renal involvement. However, reports of renal involvement in patients with RA and antineutrophil cytoplasmic autoantibody (ANCA)-associated pauci-immune glomerulonephritis are rare. Recently, we experienced two patients with RA who developed azotemia and were finally diagnosed with ANCA-associated pauci-immune glomerulonephritis. Because of the rarity of these cases, we report two cases in patients with RA with a literature review.
Amyloidosis ; Arthritis, Rheumatoid ; Azotemia ; Cytoplasm ; Glomerulonephritis ; Glomerulosclerosis, Focal Segmental ; Humans

We report on two children with a high risk of recurrent focal segmental glomerulosclerosis (FSGS) after renal transplantation that could be effectively prevented by prophylactic administration of cyclosporine combined with preemptive plasmapheresis prior to renal transplantation.
Child ; Cyclosporine ; Glomerulosclerosis, Focal Segmental ; Humans ; Kidney Transplantation ; Plasmapheresis

Focal segmental glomerulosclerosis (FSGS) is thought to be caused by FSGS permeability factor (FSGF) in the plasma, and this plasma FSGF might be responsible for FSGS recurrence after transplantation. Therefore, to reduce the FSGF in plasma, plasmapheresis (PE) is usually used to treat recurred FSGS. We report here on the PE treatment of 33-year-old women who had recurrence of FSGS after transplantation. After recurrence, she was treated by intensive PE for 1 month and she achieved complete remission. But because the proteinuria was increased when we stopped PE, we regularly continued PE for 28 month with the patient in a state of partial remission. To the best of our knowledge, this is the second report on treating recurred FSGS with intensive PE and this is the first report for long term maintenance with performing regular PE.
Adult ; Female ; Glomerulosclerosis, Focal Segmental ; Humans ; Kidney ; Kidney Transplantation ; Permeability ; Plasma ; Plasmapheresis ; Proteinuria ; Recurrence ; Transplants

The publication of the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines on the treatment of glomerular diseases in 2012 marked a milestone in this field, asitisthe first time that comprehensive guidelines are provided for such disease entities. The current review focuses on major findings, both path ogenesis related and clinical, in the primary glomerulonephritis that have been made after the guidelines came into effect.
Glomerulonephritis* ; Glomerulonephritis, IGA ; Glomerulonephritis, Membranoproliferative ; Glomerulonephritis, Membranous ; Glomerulosclerosis, Focal Segmental ; Kidney Diseases ; Nephrosis, Lipoid ; Publications