4.Mesangial IgA/IgG Deposit Glomerulonephritis.
Suk Ho CHUNG ; Sung Soon KIM ; Hong Do CHA ; Jung Sil CHO ; In Joon CHOI
Yonsei Medical Journal 1974;15(2):128-135
Percutaneous renal biopsy was performed on a 34 year old male patient with mild proteinuria and microhematuria. Histopathologic examination showed a focal mesangiopathic glomerulonephritis, simulating a "minimal change" disease pattern by light microscope. Granular deposits of IgA, C3, IgG, IgM, and fibrinogen were present in the glomerular mesangial area by immunofluorescent technique. A special prevalence of IgA was found. The intensity of immunofluorescent staining was correlated with the mesangial proliferative reaction by light microscopy. Electron microscopy showed electron dense granular deposits in the mesangial areas. The glomerulonephritis in this patient was related with the IgA antibody associated mesangial immune complex deposit disease mediated by the classic complement pathway. This glomerulonephritis is known to have a good prognosis. The antigenic nature, the reason of predominant immune deposits in the mesangium, and the mechanism of a special prevalence of IgA and IgM immunoglobulin classes are discussed, and special attention to the value of immunofluorescent study of renal diseases, with a review of the literature, is given.
Adult
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Case Report
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Glomerulonephritis/immunology*
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Glomerulonephritis/pathology
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Human
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Immunoglobulin A/analysis*
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Immunoglobulin G/analysis*
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Kidney/ultrastructure
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Male
5.Clinical and pathological features of IgA nephropathy in west Guangdong province.
Wei-ling CHEN ; Hua-peng LIN ; Hua-feng LIU
Journal of Southern Medical University 2010;30(5):1150-1151
OBJECTIVETo analyze the pathological and clinical features of IgA nephropathy (IgAN) in west Guangdong province.
METHODSThe pathological type and clinical features of 120 patients with IgAN were retrospectively analyzed.
RESULTSMesangial proliferative glomerulonephritis and focal segmental glomerulosclerosis were the most frequent features of IgAN. IgM deposit could be found in half of the IgAN patients, especially in the IgAN patients with focal segmental glomerulosclerosis.
CONCLUSIONThe incidence of IgAN may vary between different regions. Clinically, misdiagnosis of other renal diseases as IgAN may often occur. The nature and severity of glomerular immunoglobulin deposition can be related to the pathogenesis and progression of IgAN.
Adult ; China ; Female ; Glomerulonephritis, IGA ; diagnosis ; pathology ; Glomerulonephritis, Membranoproliferative ; pathology ; Glomerulosclerosis, Focal Segmental ; pathology ; Humans ; Male ; Retrospective Studies ; Young Adult
6.Podocyte depletion in children with hepatitis B virus-associated membranous nephropathy.
Yu ZHANG ; Jian-hua ZHOU ; Hong-tao WANG
Chinese Journal of Pediatrics 2007;45(5):344-348
OBJECTIVEHepatitis B virus-associated membranous nephropathy (HBV-MN) is a disease characterized by podocytopathy. Podocyte is a terminally differentiated cell with limited capability of proliferation. Thus, damage of podocyte might result in decreased cell number, and then lead to the development of marked proteinuria and glomerulosclerosis. The present study aimed to investigate the changes of glomerular podocyte number in the children with hepatitis B virus-associated membranous nephropathy (HBV-MN), and their significance in the pathogenesis of HBV-MN.
METHODSPodocytes were identified through specific immunohistological staining of Wilms tumor gene protein 1 (WT1), a characteristic marker for podocyte nuclei, and podocyte numerical density (Nv), mean glomerular tuft volume (V) and the podocyte number per glomerulus (Npodo) were estimated through Weibel-Gomez method in 19 children with biopsy-proven HBV-MN and 8 children with thin basement membrane disease (control group), and analyses were made for possible correlation with clinical, serological and pathological data.
RESULTSAmong the 19 cases with HBV-MN, 3 showed microvillus-like foot process of podocytes, granular degeneration of podocyte were found in 4 cases, vacuolization in 1 case and podocyte detachment in 2 cases. Nv and Npodo were significantly decreased in children with HBV-MN compared with control group (t = 12.851, P = 0.0002 and t = 6.433, P = 0.0002, respectively). Moreover, the number of podocytes decreased more significantly in patients with stronger HBsAg deposition (> ++) than those with weak HBsAg deposition (< or = ++), P = 0.004, but no significant difference was found between patients with phase III or IV of HBV-MN and those with phase Ior II in podocyte number per glomerulus (P = 0.5262) and podocyte numerical density (P = 0.3564). Podocyte numerical density decreased more significantly in patients with massive proteinuria (> or = 2 g/24 h) than those with moderate proteinuria (< 2 g/24 h), P = 0.0488. The numbers of podocyte correlated significantly with serum levels of C(3) (r = 0.548, P = 0.028), but did not correlate with serum levels of albumin (r = -0.037, P = 0.891).
CONCLUSIONAll patients with HBV-MN showed podocyte damage and decreased number per glomerulus, which may play an important role in the pathogenesis of HBV-MN in children.
Cell Count ; Child ; Glomerulonephritis ; pathology ; Glomerulonephritis, Membranous ; complications ; virology ; Hepatitis B ; complications ; pathology ; Hepatitis B virus ; Humans ; Kidney Diseases ; pathology ; Kidney Glomerulus ; pathology ; Podocytes ; pathology ; Proteinuria ; pathology
7.Primary IgA nephropathy in 46 children: association of clinical and pathological findings with prognosis.
Ya-ping WANG ; Ai-min LIU ; Yu-wen DAI
Chinese Journal of Pediatrics 2005;43(11):866-867
Adolescent
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Child
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Female
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Glomerulonephritis, IGA
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diagnosis
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pathology
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Humans
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Male
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Prognosis
8.Issues on renal biopsy diagnosis.
Chinese Journal of Pathology 2012;41(2):73-75
Biopsy
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methods
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Glomerulonephritis, IGA
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pathology
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Humans
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Kidney
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pathology
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Kidney Diseases
;
pathology
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Lupus Nephritis
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pathology
9.Statistical Prediction in Pathological Types of Chronic Kidney Disease.
Mei-Fang SONG ; Zong-Wei YI ; Xue-Jing ZHU ; Xue-Ling QU ; Chang WANG ; Zai-Qi ZHANG ; Lin SUN ; Fu-You LIU ; Yuan YANG
Chinese Medical Journal 2018;131(22):2741-2742