1.Analysis of 94 cases of IgA nephropathy in children.
Hua-Xiong MAO ; Zhu-Wen YI ; Li LIANG ; Yi-Wei HE ; Xi-Qiang DANG ; Xiao-Chun WU ; Xiao-Jie HE ; Shuang-Hong MO
Journal of Central South University(Medical Sciences) 2007;32(1):174-178
OBJECTIVE:
To evaluate the clinical and pathological features of 94 children suffering from IgA nephropathy (IgAN) while estimating the prevalent situation in Hunan province.
METHODS:
To summarize the annual number of hospitalized children, those with kidney diseases, those accepted biopsy, and those confirmed as IgAN in both Xiangya Hospital and Second Xiangya Hospital undertaking kidney biopsy in Hunan province during 1995 and 2004.
RESULTS:
In the past 10 years, as the hospitalized population in both hospitals accrued to 9.98% each year. The rate of 7.5% was seen in those with kidney diseases. Among whom 56.3% accepted kidney biopsy and 94 of them were confirmed as IgAN. Hematuria was the main clinical presentation, seen in 71 cases, accounting to 76%, and even to 98% after excluding those with nephrotic syndrome and isolating proteinuria type of IgAN. Inflammation infiltration (91%), renal tubule degeneration (81%), and renal interstitial fibrosis (31%) were the major pathological features of 94 children, especially in nephrotic syndrome IgAN.
CONCLUSION
The number of children with IgAN synchronously accrues as hospitalized population, those with kidney diseases, and those by kidney biopsy. Hematuria is the major symptom. To routinely perform urine analysis and kidney biopsy in asymptomatic hematuria may improve the diagnosis. Inflammation infiltration, renal tubule degeneration, and renal interstitial fibrosis are the major pathological features in IgAN children, especially in nephrotic syndrome IgAN, probably relating to continuous proteinuria. Early control of proteinuria may delay or decrease renal tubule fibrosis.
Adolescent
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Biopsy, Needle
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Child
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Child, Preschool
;
China
;
epidemiology
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Female
;
Glomerulonephritis, IGA
;
complications
;
epidemiology
;
pathology
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Hematuria
;
diagnosis
;
etiology
;
Hospitalization
;
statistics & numerical data
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Humans
;
Kidney
;
pathology
;
Male
2.Beta-Thalassemia Minor Is Associated with IgA Nephropathy.
Jung Hyun KANG ; Bo Rha PARK ; Kyung Soo KIM ; Do Yeun KIM ; Hee Jin HUH ; Seok Lae CHAE ; Sung Joon SHIN
Annals of Laboratory Medicine 2013;33(2):153-155
No abstract available.
Aged
;
Anemia/diagnosis
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Bone Marrow Cells/pathology
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Chromosomes, Human, Pair 11
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Electrophoresis
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Glomerulonephritis, IGA/complications/*diagnosis
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Hematuria/pathology
;
Hemoglobin A/analysis
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Heterozygote
;
Humans
;
Male
;
Renal Insufficiency/diagnosis
;
beta-Globins/genetics
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beta-Thalassemia/*diagnosis/etiology
3.Clinical analysis of proteinuria and glomerular lesions in Henoch-Schönlein purpura nephritis of adults.
Dong-yan LIU ; Yu-bing WEN ; Hang LI ; Xue-wang LI
Acta Academiae Medicinae Sinicae 2005;27(2):237-240
OBJECTIVETo analyze the characteristics of proteinuria and glomerular lesions in Henoch-Schönlein purpura nephritis (HSPN) of adults.
METHODSThe pathologic results and clinical data of 103 HSPN patients were analyzed.
RESULTSPatients with mild or moderate proteinuria accounted for 40.8% and 37.9%, respectively. Patients with nephropathic proteinuria accounted for about 21.4%. Severer proteinuria resulted in higher blood pressure and increased cholesterol, and albumin decreased gradually (P < 0.01); meanwhile, total glomerular lesion, tubulointerstitial lesion, and vascular lesion also became severer (P < 0.01).
CONCLUSIONProteinuria may indirectly reflect the severity of glomerular lesions in HSPN of adults.
Adolescent ; Adult ; Aged ; Female ; Glomerulonephritis, IGA ; diagnosis ; etiology ; Humans ; Immunoglobulin A ; blood ; Immunoglobulin G ; blood ; Immunoglobulin M ; blood ; Kidney Glomerulus ; pathology ; Kidney Tubules ; pathology ; Male ; Middle Aged ; Nephritis ; diagnosis ; etiology ; Proteinuria ; etiology ; urine ; Purpura, Schoenlein-Henoch ; complications ; pathology ; Retrospective Studies
4.Immunoglobulin A Nephropathy Associated with Plasmodium falciparum Malaria.
Dong Eun YOO ; Jeong Ho KIM ; Jeong Hae KIE ; Yoonseon PARK ; Tae Ik CHANG ; Hyung Jung OH ; Seung Jun KIM ; Tae Hyun YOO ; Kyu Hun CHOI ; Shin Wook KANG ; Seung Hyeok HAN
Journal of Korean Medical Science 2012;27(4):446-449
Glomerulonephritis occurs as a rare form of renal manifestation in Plasmodium falciparum malaria. Herein, we report a case of falciparum malaria-associated IgA nephropathy for the first time. A 49-yr old male who had been to East Africa was diagnosed with Plasmodium falciparum malaria. Microhematuria and proteinuria along with acute kidney injury developed during the course of the disease. Kidney biopsy showed mesangial proliferation and IgA deposits with tubulointerstitial inflammation. Laboratory tests after recovery from malaria showed disappearance of urinary abnormalities and normalization of kidney function. Our findings suggest that malaria infection might be associated with IgA nephropathy.
Acute Kidney Injury/etiology/pathology
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Antimalarials/therapeutic use
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Creatinine/blood
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Glomerulonephritis, IGA/*diagnosis/*etiology
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Hematuria/etiology
;
Humans
;
Immunoglobulin A/*metabolism
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Malaria/*complications/drug therapy/*pathology
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Male
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Middle Aged
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Plasmodium falciparum/*isolation & purification
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Proteinuria/etiology
;
Quinine/therapeutic use
5.Renal Manifestations in 2007 Korean Patients with Behcet's Disease.
Sung Bin CHO ; Jihyun KIM ; Shin Wook KANG ; Tae Hyun YOO ; Zhenlong ZHENG ; Suhyun CHO ; Hye Sun LEE ; Dongsik BANG
Yonsei Medical Journal 2013;54(1):189-196
PURPOSE: Behcet's disease (BD) theoretically affects all sizes and types of blood vessels and results in multi-organ involvement. However, renal BD has not been fully characterized, though the kidneys are histologically rich in blood vessels. MATERIALS AND METHODS: A total of 2007 patients who fulfilled the diagnostic criteria for BD were enrolled in this study. We reviewed the medical records and test results of the BD patients and used univariate and multivariate logistic regression analyses to determine the clinical significance of renal involvement in BD. RESULTS: Among the 2007 BD patients, we noted hematuria in 412 (20.5%) and proteinuria in 29 (1.4%). Univariate analysis showed that the BD patients with hematuria were predominantly female and older, had higher erythrocyte sedimentation rates (ESRs), and more frequently presented with genital ulcerations. BD patients with proteinuria had higher ESR levels compared to BD patients without proteinuria. In the multivariate analysis, age, sex, and ESR were found to be significantly associated with hematuria in BD patients, whereas only ESR was associated with proteinuria in BD patients. We also found that IgA nephropathy was the most common pathologic diagnosis in 12 renal BD patients who underwent renal biopsies. CONCLUSION: We suggest that routine urinalysis and serum renal function tests be performed for the early detection of renal BD, especially in older female BD patients with recurrent hematuria, high ESR levels, and frequent genital ulcers, as well as in BD patients with proteinuria and high ESR levels.
Adolescent
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Adult
;
Age Factors
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Aged
;
Aged, 80 and over
;
Behcet Syndrome/*complications/epidemiology/*metabolism
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Biopsy
;
Female
;
Glomerulonephritis, IGA/complications/diagnosis
;
Hematuria/complications/diagnosis
;
Humans
;
Kidney/*pathology
;
Kidney Diseases/*diagnosis
;
Logistic Models
;
Male
;
Middle Aged
;
Multivariate Analysis
;
Proteinuria/complications/diagnosis
;
Republic of Korea
;
Young Adult
6.Crohn's Disease in Association with IgA Nephropathy.
Ji Myoung LEE ; Kang Moon LEE ; Hyung Wook KIM ; Woo Chul CHUNG ; Chang Nyol PAIK ; Jeong Rok LEE ; Yeong Jin CHOI ; Jin Mo YANG
The Korean Journal of Gastroenterology 2008;52(2):115-119
Urological complications are not uncommon in Crohn's disease (CD). The most common manifestations are renal stones, enterovesical fistulas, and ureteral obstruction, but renal parenchymal disease has rarely been reported. IgA nephropathy, the most common form of primary glomerulonephritis, is usually isolated, but can be sometimes associated with chronic extrarenal disorders such as inflammatory bowel disease. We describe a case of 36 year-old man with CD associated with IgA nephropathy. He was diagnosed as CD 6 years ago and at that time, isolated proteinuria was observed. He presented recurrent proteinuria and elevation of creatinine level while he had been managed well with mesalamine and azathioprine. The renal biopsy was performed and IgA nephropathy (type IV) was diagnosed. Strict blood pressure control with angiotensin converting enzyme inhibitor and calcium channel blocker resulted in clinical improvement and normalization of serum creatinine level.
Adult
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Angiotensin-Converting Enzyme Inhibitors/therapeutic use
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Anti-Inflammatory Agents, Non-Steroidal/therapeutic use
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Antimetabolites/therapeutic use
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Azathioprine/therapeutic use
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Blood Pressure
;
Calcium Channel Blockers/therapeutic use
;
Colonoscopy
;
Crohn Disease/*diagnosis/drug therapy/etiology
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Glomerulonephritis, IGA/complications/*diagnosis/pathology
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Humans
;
Male
;
Mesalamine/therapeutic use
;
Proteinuria/diagnosis/etiology