PURPOSE: To characterize the CT and MR findings in patients with meningioangiomatosis(MA). MATERIALS AND METHODS: Four patients (18 to 53 years old, two females and two males) with MA were retrospectively reviewed. CTwas used in four cases and MR in three. Pathologic specimens were obtained from all four. RESULT: All lesions were located in the cortical and subcortical areas and showed spotty(n=1), popcornlike(n=2), or gyral(n=1) calcification. The mass were associated with surrounding edema and gliosis. In two patients, lesions were multiple and were accompanied by eccentric cysts. CONCLUSION: MA is a surgically correctable benign disease. Its radiologic characteristics are cortical or subcortical mass with various calcifications, associated peripheral edema and gliosis.
Edema ; Female ; Gliosis ; Humans ; Middle Aged ; Retrospective Studies

We report a case of disseminated calcific cysticercosis of brain, accompanied with marked hydrocephalus. Histopathologically, the calcific spots consisted of mummified scolex and bladder of cysticercus cellulosae with a diffuse calcification, but no area of cystic change were noted. Surrounding brain tissue showed a dense fibrous reaction and gliosis with little foreign body reaction.
Brain* ; Cysticercosis ; Cysticercus ; Foreign-Body Reaction ; Gliosis ; Hydrocephalus ; Urinary Bladder

Retinal dysplasia is defined as an abnormal differentiation of the retina with proliferation of its elements into resettes, folds, and gliosis. The clinical presentation is usually bilateral with a variety fo systemic abnormalities. We experienced a case of unilateral retinal dysplasia without systemic abnormalities occurring in a 2-month-old girl who underwent an enucleation of her right eye because of the possibility of retinoblastoma. We reviewed the available literatures regarding this disease.
Female ; Gliosis ; Humans ; Infant ; Retina ; Retinal Dysplasia* ; Retinaldehyde* ; Retinoblastoma

Retinal dysplasia is defined as an abnormal differentiation of the retina with proliferation of its elements into resettes, folds, and gliosis. The clinical presentation is usually bilateral with a variety fo systemic abnormalities. We experienced a case of unilateral retinal dysplasia without systemic abnormalities occurring in a 2-month-old girl who underwent an enucleation of her right eye because of the possibility of retinoblastoma. We reviewed the available literatures regarding this disease.
Female ; Gliosis ; Humans ; Infant ; Retina ; Retinal Dysplasia* ; Retinaldehyde* ; Retinoblastoma

Retinal dysplasia is an abnormal differentiation of the retina at embryonal retina stage with proliferation of its elements into rosettes, fold, and gliosis and it is very difficulat to distinguish between the various types of intraocular disease, especilaly retinoblastoma. We experienced a case of unilateral retinal dysplasia without systemic abnormalities occurring in a 5 months old boy. It was clinically suspected Retinoblastoma, which was proved to be Retinal Dysplasia by histopathologic examination.
Gliosis ; Humans ; Infant ; Male ; Retina ; Retinal Dysplasia* ; Retinaldehyde* ; Retinoblastoma

High-dose methylprednisolone (MP) has been shown to play an important role in traumatic optic nerve injury. The purpose of this study was to investigate histopathologic changes of the injured optic nerve with time course after experimental trauma to the optic nerve had been induced. The optic nerve trauma was made by rotating the eyeball in rabbits. Twelve rabbits were divided into three groups (Group 1; 2 weeks, Group 2; 1 month, and Group 3; 2 months) according to time course after MP administration. Each group comprised of control group and treatment group. MP significantly reduced damage of the myelinated nerve and gliosis in comparision with the control group, when MP was administered IV immediately after trauma in the treatment group at a bolus of 30mg/kg, two times for 3 days, with a subsequent continuous MP infusion at 30mg/kg for 4 days. And massive gliosis and damage of the myelinated nerve in the control group were oberserved on electron microscopy. However, we could not find PMNLs, macrophages, and proliferation of fibroblast in both the control group and treatment group. It is possible that high-dose MP protects further damage of the injured optic nerve and that the beneficial effect is partially due to its antioxidant rather than its anti-inflammatory effect. This histopathologic study indicated that high-dose MP might improve the neurological outcome in the injured optic nerve.
Fibroblasts ; Gliosis ; Macrophages ; Methylprednisolone* ; Microscopy, Electron ; Myelin Sheath ; Optic Nerve Injuries ; Optic Nerve* ; Rabbits

Neuroinflammation such as reactive gliosis and microglial activations are important pathological findings of ALS. We present a first autopsy case of ALS in Korea related with neuroinflammatory change. A 67-year-old ALS patient suddenly expired due to accidental head trauma. Gross autopsy finding showed marked atrophic change in spinal cord. Pathological finding include a marked loss of motor neurons, reactive gliosis and microglial infiltrations. These findings suggest neuroinflammation may play a role in pathogenesis of ALS.
Aged ; Amyotrophic Lateral Sclerosis ; Autopsy ; Craniocerebral Trauma ; Gliosis ; Humans ; Korea ; Motor Neurons ; Spinal Cord

A case of the tuberous sclerosis, 14-years old boy, was observed. In his father and sister, the cerebral tubers were noted by brain computerized tomography. This disease has been reported occasionally in dermatologic and psychiatric department because of adenoma sebaceum, mental retardation and epilepsy respectively, but it has not been reported at neurosurgical department in Korea. The histopathology of the brain lesion showed atypical cell(tuberous sclerosis cell), gliosis and nonspecific calcification which confirmed the diagnosis of tuberous sclerosis.
Adolescent ; Brain ; Diagnosis ; Epilepsy ; Fathers ; Gliosis ; Humans ; Intellectual Disability ; Korea ; Male ; Sclerosis ; Siblings ; Tuberous Sclerosis*

OBJECTIVE: The advent of high resolution magnetic resonance imaging(MRI) contributed to the preoperative localization of epileptogenic area. Even the discrete lesion visualized on MRI can be often correlated with seizure onset zone. If MRI does not, however, show any lesions in the extratemporal epilepsy, it imposes a significant challenge. This study is designed to evaluate the surgical treatment of extratemporal lobe epilepsy in which MRI does not show any lesion, to define the surgical strategy and to investigate the underlying pathology. METHODS: We studied the nineteen patients with MRI-negative extratemporal epilepsy who underwent resective surgery after careful preoperative investigation between 1993 and 1995. RESULTS: Scalp EEG could not lateralize the epileptogenic foci in 9 patients. Intracranial EEG recording was performed in all patients with successful localization: depth electrode study in 12, and subdural grid and strip study in 7 patients. Resection was performed in frontal(n=14), in parietal(n=3), and in multilobar area(n=2). Pathological findings comprised cortical dysplasia in 10, gliosis in 7, and collagenoma in one patients. The surgical outcome was classified as seizure free in 10, rare seizures in 2, significant reduction in 5, and no change in 2 patients. CONCLUSION: MRI-invisible extratemporal epilepsy can be managed surgically with promising results. Cortical dysplasia and gliosis are two major pathological findings in this context though MRI does not demonstrate any lesions.
Electrodes ; Electroencephalography ; Epilepsy* ; Gliosis ; Humans ; Magnetic Resonance Imaging ; Malformations of Cortical Development ; Pathology ; Scalp ; Seizures

A patient presenting with the characteristic clinical features of the dementia of Pick's type is described, in whom neuropathological examination of brain biopsy material revealed atypical features, including extensive subcotical gliosis with mild cortical neuronal loss and without any neuronal cytoskeletal inclusions (Pick bodies, neurofibrillary tangles, and Lewy bodies) and amyloid deposits (senile plaques). And she has the suggestive family history of the same clinical features in her two brothers. So, the clinical and pathological features are discussed with particular reference to typical Alzheimer's disease and Pick's disease, and it is proposed that the case should be classified as familial progressive subcortical gliosis.
Alzheimer Disease ; Biopsy ; Brain ; Dementia ; Gliosis* ; Humans ; Neurofibrillary Tangles ; Neurons ; Pick Disease of the Brain ; Plaque, Amyloid ; Siblings