1.Use of the ultrasound-based total malignancy score in the management of thyroid nodules.
Giovanni Guido POMPILI ; Silvia TRESOLDI ; Anna RAVELLI ; Alessandra PRIMOLEVO ; Giovanni DI LEO ; Gianpaolo CARRAFIELLO
Ultrasonography 2018;37(4):315-322
PURPOSE: The purpose of this study was to validate the role of the total malignancy score (TMS) in identifying thyroid nodules suspicious for malignancy through the sum of their ultrasound features. METHODS: The local ethical committee approved this prospective observational study. We examined 231 nodules in 231 consecutive patients (164 females and 67 males; age range, 20 to 87 years; median age, 59 years; interquartile range, 48 to 70 years) who underwent ultrasound followed by fine-needle aspiration cytology (FNAC). The nodules were further classified using the TMS, which considers ultrasound features (number, echogenicity, structure, halo, margins, Doppler signal, calcifications, and growth), and the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC), which considers cytological features. Patients with non-negative nodules (TBSRTC categories III to VI) underwent histological analysis, repeated FNAC, or 2 years of regular ultrasound follow-up. The associations between the final diagnosis, each of the ultrasound features, and the TMS were estimated using the chi-square test, the Mann-Whitney U test, and multivariate logistic regression. A receiver operating characteristic (ROC) curve was used to evaluate the diagnostic accuracy of the TMS. RESULTS: On ultrasound, 47% of the nodules (108 of 231) had a TMS < 3, 18% (42 of 231) had a TMS of 3, and 35% (81 of 231) had a TMS >3. The FNAC results of 85% of the nodules (196 of 231) were benign, while 15% (35 of 231) had non-negative results. Hypoechogenicity, solid structure, the presence of microcalcifications, and the number of nodules were independent predictors of the final diagnosis, and the diagnostic accuracy of the TMS was good (area under the ROC curve, 0.82). CONCLUSION: The TMS system is simple to use, reliable, easily reproducible, and closely reflects malignancy risk. Based on our results, FNAC could be limited to nodules with a TMS ≥3 without missing any cases of carcinoma.
Biopsy, Fine-Needle
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Cytodiagnosis
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Diagnosis
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Diagnostic Imaging
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Female
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Follow-Up Studies
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Humans
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Logistic Models
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Male
;
Observational Study
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Prospective Studies
;
ROC Curve
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Thyroid Gland*
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Thyroid Neoplasms
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Thyroid Nodule*
;
Ultrasonography
2.The role of contrast-enhanced ultrasonography in image-guided liver ablations.
Lorenzo Carlo PESCATORI ; Luca Maria SCONFIENZA ; Giovanni MAURI
Ultrasonography 2016;35(1):87-88
No abstract available.
Liver*
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Ultrasonography*
3.Endoscopic Treatment of Iatrogenic Perforation of Sigmoid Diverticulum: A Case Report of Multidisciplinary Management
Giacomo Emanuele Maria RIZZO ; Giuseppina FERRO ; Giovanna RIZZO ; Giovanni Di CARLO ; Alessandro CANTONE ; Gaetano Giuseppe Di VITA ; Carmelo SCIUMÈ
Clinical Endoscopy 2022;55(2):292-296
Iatrogenic perforations are severe complications of gastrointestinal endoscopy; therefore, their management should be adequately planned. A 77-year-old man with a history of diverticulosis underwent a colonoscopy for anemia. During the procedure, an iatrogenic perforation occurred suddenly in the sigmoid colon, near a severe angle among the numerous diverticula. Through-the- scope clips were immediately applied to treat it and close mucosal edges. Laboratory tests showed increased inflammation and infection, and although there were no complaints of abdominal pain, the patient had an extremely distended abdomen. A multidisciplinary board began management based on a conservative approach. Pneumoperitoneum was treated with computed tomography-assisted drainage. After 72 hours, his intestinal canalization and laboratory tests were normal. Though this adverse event is rare, a multidisciplinary board should be promptly gathered upon occurrence, even if the patient appears clinically stable, to consider a conservative approach and avoid surgical treatment.
4.The Burden of Agoraphobia in Worsening Quality of Life in a Community Survey in Italy
Antonio PRETI ; Martina PIRAS ; Giulia COSSU ; Elisa PINTUS ; Mirra PINTUS ; Goce KALCEV ; Federico CABRAS ; Maria Francesca MORO ; Ferdinando ROMANO ; Matteo BALESTRIERI ; Filippo CARACI ; Liliana DELL’OSSO ; Guido Di SCIASCIO ; Filippo DRAGO ; Maria Carolina HARDOY ; Rita RONCONE ; Carlo FARAVELLI ; Mario MUSU ; Gabriele FINCO ; Antonio Egidio NARDI ; Mauro Giovanni CARTA
Psychiatry Investigation 2021;18(4):277-283
Objective:
Current nosology redefined agoraphobia as an autonomous diagnosis distinct from panic disorder. We investigated the lifetime prevalence of agoraphobia, its association with other mental disorders, and its impact on the health-related quality of life (HR-QoL).
Methods:
Community survey in 2,338 randomly selected adult subjects. Participants were interviewed with the Advanced Neuropsychiatric Tools and Assessment Schedule (ANTAS), administered by clinicians. The diagnoses were based on the ICD-10 criteria. The Short-Form Health Survey (SF-12) was used to quantify HR-QoL.
Results:
In the sample, 35 subjects met the criteria for agoraphobia (1.5%), with greater prevalence among women (2.0%) than men (0.9%): odds ratio (OR) 2.23; 95% CI: 1.0-5–2. Agoraphobia was more often seen among those with (n=26; 1.1%) than without (n=9; 0.4%) panic disorder: OR=8.3; 2.9–24.4. Co-morbidity with other mental disorders was substantial. The mean score of SF-12 in people with agoraphobia was 35.2±7.8, with similar levels of HR-QoL in people with (35.3±7.9) or without (34.8±7.3) panic disorder: ANOVA: F(1;33)=0.0; p=1.00.
Conclusion
One out of seventy people may suffer from agoraphobia in their lifetime. The attributable burden in terms of HR-QoL is substantial and comparable to the one observed for chronic mental disorders such as major depression, post-traumatic stress disorder, or obsessive-compulsive disorder.
5.The Burden of Agoraphobia in Worsening Quality of Life in a Community Survey in Italy
Antonio PRETI ; Martina PIRAS ; Giulia COSSU ; Elisa PINTUS ; Mirra PINTUS ; Goce KALCEV ; Federico CABRAS ; Maria Francesca MORO ; Ferdinando ROMANO ; Matteo BALESTRIERI ; Filippo CARACI ; Liliana DELL’OSSO ; Guido Di SCIASCIO ; Filippo DRAGO ; Maria Carolina HARDOY ; Rita RONCONE ; Carlo FARAVELLI ; Mario MUSU ; Gabriele FINCO ; Antonio Egidio NARDI ; Mauro Giovanni CARTA
Psychiatry Investigation 2021;18(4):277-283
Objective:
Current nosology redefined agoraphobia as an autonomous diagnosis distinct from panic disorder. We investigated the lifetime prevalence of agoraphobia, its association with other mental disorders, and its impact on the health-related quality of life (HR-QoL).
Methods:
Community survey in 2,338 randomly selected adult subjects. Participants were interviewed with the Advanced Neuropsychiatric Tools and Assessment Schedule (ANTAS), administered by clinicians. The diagnoses were based on the ICD-10 criteria. The Short-Form Health Survey (SF-12) was used to quantify HR-QoL.
Results:
In the sample, 35 subjects met the criteria for agoraphobia (1.5%), with greater prevalence among women (2.0%) than men (0.9%): odds ratio (OR) 2.23; 95% CI: 1.0-5–2. Agoraphobia was more often seen among those with (n=26; 1.1%) than without (n=9; 0.4%) panic disorder: OR=8.3; 2.9–24.4. Co-morbidity with other mental disorders was substantial. The mean score of SF-12 in people with agoraphobia was 35.2±7.8, with similar levels of HR-QoL in people with (35.3±7.9) or without (34.8±7.3) panic disorder: ANOVA: F(1;33)=0.0; p=1.00.
Conclusion
One out of seventy people may suffer from agoraphobia in their lifetime. The attributable burden in terms of HR-QoL is substantial and comparable to the one observed for chronic mental disorders such as major depression, post-traumatic stress disorder, or obsessive-compulsive disorder.
6.Monitoring the activities of Italian colposcopy clinics before and during the COVID-19 pandemic
Giovanni Delli CARPINI ; Paolo Giorgi ROSSI ; Luca GIANNELLA ; Jacopo Di GIUSEPPE ; Nicolò CLEMENTE ; Francesco SOPRACORDEVOLE ; Maggiorino BARBERO ; Giorgio BOGANI ; Rosa De VINCENZO ; Massimo ORIGONI ; Francesco CANTATORE ; Barbara GARDELLA ; Mattia DOMINONI ; Ermelinda MONTI ; Carlo Antonio LIVERANI ; Anna VISCARDI ; Alessio PAGAN ; Andrea AMADORI ; Chiara ALESSI ; Matteo ANDOLFATTO ; Paolo CATTANI ; Annalisa PIERALLI ; Guido STEVENAZZI ; Andrea CIAVATTINI
Journal of Gynecologic Oncology 2023;34(1):e7-
Objective:
To evaluate the impact of healthcare reorganization during the severe acute respiratory syndrome coronavirus 2 pandemic on Italian colposcopy clinic activities, focusing on cervical excision procedures, follow-ups for conservative management of low-grade lesions, and follow-ups post cervical excision.
Methods:
Retrospective study conducted in 14 Italian colposcopy clinics. The number and clinical characteristics of cervical excisions, follow-ups for conservative management of low-grade lesions, and follow-ups after cervical excision were compared between the period March 1, 2019 to February 29, 2020 (pre-pandemic) and March 1, 2020 to February 28, 2021 (pandemic) with a Poisson regression analysis.
Results:
In the pandemic period, the number of cervical excisions was reduced by 8.8% (95% confidence interval [CI]=−15.6% to −2%; p=0.011). Excisions were less frequently performed in the operating room (−35.1%; 95% CI=−47.6% to −22.6%; p<0.001), the number of patients from spontaneous screening was reduced by −14.0% (95% CI=−23.4% to −4.6%; p=0.003), and the CO2-laser technique was used less frequently (−30%; 95% CI=−45.1% to −15.0%; p<0.001). As compared to the pre-pandemic period, the number of follow-ups for conservative management of low-grade lesions was reduced by −26.7% (95% CI=−39.0% to −14.4%; p<0.001), and the follow-up appointments after cervical excision were reduced by −51.0% (95% CI=−58.1% to −43.9%; p<0.001).
Conclusion
The most significant impact of the healthcare reorganization during the coronavirus disease 2019 pandemic was on follow-ups after cervical excision. The resumption of disrupted activities should follow a risk-based prioritization, starting from women in follow-up after cervical excision. It is advisable that the trend of performing cervical excision as an outpatient procedure is maintained in the post-pandemic period.