No abstract available.
Azithromycin* ; Fibroblasts* ; Gingival Hyperplasia

The fibrous epulis, a common tumor-like lesion of the gingiva, appears in the interdental papilla as a result of local irritation. Lesions are asymptomatic and have a variable growth rate. A 75-year-old woman was referred for the evaluation of a large painless gingival mass. It had started 10 years back and has been increasing in size the last year. No bone involvement was noted. The tumor was totally removed by excision with surgical scalpel under local anesthesia without teeth extraction. The microscopic findings were suggestive of a fibrous epulis. Differential diagnosis, clinical considerations and factors to prevent recurrence are discussed.
Aged ; Diagnosis, Differential ; Female ; Fibrosis ; Follow-Up Studies ; Gingival Diseases ; pathology ; Gingival Hyperplasia ; pathology ; Humans ; Maxilla

Gingival Hyperplasia/diagnosis* ; Humans ; Immunoglobulin G ; Immunoglobulin G4-Related Disease

Humans ; Nephrotic Syndrome/therapy* ; Gingival Hyperplasia/surgery* ; Gingivectomy

Enlargement of the gingival caused by phenytoin. An anticonvulsant used in the treatment of epilepsy, occurs in some of the patients receiving the drug. Its incidence varies from 3 to 62 percent, with the greater frequencies in younger patients. The hyperplasia is usually generalized throughout the mouth, but is more severe tendency in the maxillary and mandibular anterior regions. 18 year old male patient was admitted to our Department of Dentistry with the complaint of generalized painless gingival swelling. After the consult of the N.M. and laboratory study, the gingivectomy and gingivoplasty was performed. The periodontal pack and tin foil was applied on the attached gingival to protect a surgical site and bleeding control. We obtained a good result of improved esthetics and function.
Dentistry ; Epilepsy ; Esthetics ; Gingival Hyperplasia* ; Gingivectomy ; Gingivoplasty ; Hemorrhage ; Humans ; Hyperplasia ; Incidence ; Male ; Mouth ; Phenytoin* ; Tin

Hyperplasia of the gingivae may occur as a secondary reaction in the treatment of epilepsy with diphenylhydantoin sodium. This study is intended to investigate the incidence and dharacteristics of gingival hyperplasia in 124 epileptic patients taking diphenylhydantoin longstandingly. The results are as follows: 1. The incidence of diphenylhydantoin induced gingival hyperplasia is approximately 69.4%. 2. The individual tolerance or sensitivity may determine the incidence and severity of gingival hyperplasia and are not directly related with the duration of drug use and its dosage. 3. Gingival hyperplasia is more frequent in female patients and younger patients than male and older. 4. There is no direct relationship betwwen occurance of gingival hyperplasia and meticulous oral hygiene. 5. The mechanism involved in a causation of diphenylhydantoin induced gingival hyperplasia has not been elucidated. 6. We recommand that diphenylhydantoin may be prescribed as the drug of the first choice for the control of epileptic seizure in the adolescent female patients and children especially receiving certain dental treatments.
Adolescent ; Child ; Epilepsy ; Female ; Gingiva ; Gingival Hyperplasia* ; Humans ; Hyperplasia ; Incidence ; Male ; Oral Hygiene ; Phenytoin ; Sodium

PURPOSE: Systemic disease can manifest oral signs at an early phase, which may be crucial for the diagnosis and timing of treatment. This report describes two patients who presented with gingival enlargement as an early sign of acute leukemia. METHODS: Two patients presented with oral symptoms including severe gingival enlargement. The progress of their symptoms was associated with underlying systemic disease. RESULTS: The patients were transferred to the Department of Hematology and diagnosed with acute myelomonocytic leukemia. They received appropriate treatment and survived. CONCLUSIONS: Gingival enlargement can be caused by underlying systemic diseases. Accurate diagnosis and timely referral are important for preventing a fatal situation. It must be emphasized that some oral signs and symptoms may be closely correlated with systemic diseases.
Dentists ; Diagnosis ; Gingival Hyperplasia ; Hematology ; Humans ; Leukemia* ; Leukemia, Myelomonocytic, Acute ; Referral and Consultation

Gingival hyperplasia is a frequent complication in transplant patients who receive cyclosporine or calcium channel blockers. We studied an unusual case involving a renal transplant recipient with post-transplant non-Hodgkin's lymphoma that manifested as gingival hyperplasia. We initially consider that it was a side effect of cyclosporine and nifedipine. The lesion did not respond to dose reductions or the withdrawal of cyclosporine and nifedipine, and the gingival hyperplasia progressed in a localized fashion, becoming ulcerated and bleeding easily. Histological examination revealed the presence of malignant lymphoma.
Male ; Lymphoma, Non-Hodgkin/complications/*diagnosis ; *Kidney Transplantation ; Humans ; Gingival Hyperplasia/*etiology ; Adult

The congenital epulis is a rare benign lesion which has an uncertain histogenesis. But, recently it is suggested that it derives either from histiocytic/mesenchymal cells or myofibroblasts which based on many immunohistochemical study. Neumann first described congenital granular cell tumor which developed from the gingiva as congenital epulis in 1871. Epulis means "on the gum" or "gumboil" in Greek word. Congenital epulis is located exclusively on the anterior or lateral alveoiar ridge with marked predilection for female infants. The mass was covered with a nonpapillated stratified squamous epithelium of uniform thickness. There was no pseudoepitheliomatous hyperplasia. Granular cells have abundant cytoplasm with distinct borders and mitotic figures were rarely found. Six days old female neonate who had 2 x3 cm sized mass with 2 x2 cm neck in the gingival and anterior alveolar ridge of mandible was operated by simple excision and coverage by local mucosal flap. After two years she had normal teeth eruption and no recurrence.
Alveolar Process ; Cytoplasm ; Epithelium ; Female ; Gingiva ; Gingival Diseases ; Gingival Neoplasms* ; Granular Cell Tumor* ; Humans ; Hyperplasia ; Infant ; Infant, Newborn ; Mandible ; Myofibroblasts ; Neck ; Recurrence ; Tooth

PURPOSE: The congenital epulis is a rare, benign tumor. It can protrude out of the newborn's mouth to prevent normal closure of the mouth and it can interfere with respiration or feeding. METHODS: An 11-day old female neonate presented with a 1.5x1.5x2.3cm sized mass in the gingival and anterior alveolar ridge of the mandible. We performed a simple excision. RESULTS: In our case, histologically, there was no pseudoepitheliomatous hyperplasia. The staining for S-100 protein, and actin was negative. After 8 months, the patient had normal teeth eruption and no recurrence of the tumor. CONCLUSION: With early detection and appropriate treatment, we were able to help the baby avoid developing any dyspnea. Nursing was possible after the mass had been removed.
Actins ; Alveolar Process ; Dyspnea ; Female ; Gingival Neoplasms ; Humans ; Hyperplasia ; Infant, Newborn ; Mandible ; Mouth ; Recurrence ; Respiration ; S100 Proteins ; Tooth