Clinically, benign juvenile melanoma (BJM) is a benign nevus-cell tumor and arise predominantly in children. The lesion usually is solitary and is encountered most commonly on the face and extremities. In most mstances the lesion consists of a dome-shaped, srnall nodule. The histoIogic picture often closely resembles that of a maIignant melanoma and there is no doubt that prior to its recognition as an entity by Spitz in 1948 many cases were misdiagnosed as malignant melanoma. A case of benign juvenile melanoma in 23-year old male is described with brief review of literatures. Hisr.ologic pictures show considerable junctional activity. In the upper dermis edema and ectasia of the various vascular elements are present. The re:us cells are pleomorphic. They are mostly spindle-shaped and are arranged mostly in fairly well circumscribed nests. Giant cells are frequentIy observed. Melanin is scanty and mitotic figures are absent. These are typical histologic pictures of the BJM, To our knowledge, there have been no prior repots of BJM in Korea, based on our own review.
Child ; Dermis ; Dilatation, Pathologic ; Edema ; Extremities ; Giant Cells ; Humans ; Korea ; Male ; Melanins ; Melanoma* ; Young Adult

No abstract available.

The warts are benign skin tumors caused by virus, most frequently seen in childhood, and have atendency to regress before reaching adulthood. Various articles have been suggested that wart involution may be involved with immune response of the host, but definite mechanism has not been found. The author studied the tuberculin sensitivities of the wart patients in order to evaluate immune responses of the hosts, and observed the course of the warts after BCG vaccination to the patients for the facilitation of nonspecific immune reaction of the hosts. The results are as follows; 1. Tuberculin positivity was not decreased, however the sensitivity to the tuberculin was decreased among the wart patients than the non-wart groups. 2. No significant difference was observed between the numbers of wart and the degrees of tuberculin sensitivity. R. BCG vaccination was promoted the invotution of warts without valuable changes of the tuberculin sensitivities.
Humans ; Mycobacterium bovis* ; Skin ; Tuberculin* ; Vaccination* ; Warts*

No abstract available.
Animals ; Mice* ; Swimming*

Human wart diseases are benign skin tumors caused by viruses of the papova group which usually affect children and almost always regress until adulthood. Various therapeutic modalities have been tried for the treatment of warts, however there is no single satisfactory method and the clinical course as well as the prognosis is always variable. The spontaneous regression of warts may represent an increase in the activity of host immune responses. Recent studies have tended to confirm that serum antiviral antihodies and cellular immune responses occur in relation to regression of warts, but there is no convincing evidence of a correlation between the appmrance of immune responses and resolution of the warts. BCG and some of similar extra,cts have becn known to be capable of initiating a wide range of non-specific immune reactions to cancerous diseases. The aim of the present investigation has been to study no-specific irnmune response of Tubercin-3 in patients with svarts, based on the findings that RCG and some of similar extracts were found to be a potent reticuloendothelial stimulant. Taventy casee attending a, dermatolo-ical out-ptient department consists of eight verrua plana juvenilis, seven verruca vulgaris, one verruca plxntaris and four molluscurn contagiosum were trezted with Tubercin-R. The results revealed complete cure in six(37. 5.) and clinical improvemeat in nine. (56. %) of sixteen cases of various warts, and one of four czses of molluscum contagiosurn showed a slight decrea,se in size and nu!nber of the lesions. There is no eviclence of a correlation among the age of patient, type of verruca and therapeutic effect. On the basis of our findings, we can state that non-specific immune response of BCG .and some of similar extracts may be facilitate the involution of warts. The relationship of thes immune respons to the involution of warts clezrly require further study.
Child ; Humans ; Immunity, Cellular ; Mycobacterium bovis ; Prognosis ; Skin ; Warts*

PURPOSE: This study was performed to find the relation between glaucoma and the quality of life (QOL). METHODS: The questionnaire survey and ophthalmologic examination was made in 105 glaucoma patients under treatment at ophthalmology clinic of a university hospital and 120 normal persons who had undergone an routine health check-up from June 1st, 2000 and June 30th, 2001. The questionnaire was composed of general characteristics, health-related behavior and the short form-36 health survey for QOL. Using the t-test, analysis of variance (ANOVA), Pearson's correlation analysis and analysis of co-variance (ANCOVA), we examined the relationship between glaucoma and QOL. RESULTS: 1. By t-test or ANOVA various domains of QOL showed statistically significant difference by sex, age, coverage of medical insurance, family history of glaucoma, past history of systemic diseases, educational level, marital status, smoking and drinking status. Visual acuity showed significant positive correlation with QOL and horizontal and vertical cup-to-disk (C/D) ratio showed significant negative correlation with QOL. 2. By ANCOVA to find the association of glaucoma with QOL controlling other related characteristics of subjects, QOL of the glaucoma group showed lower than that of the normal group, but the differences were not statistically significant. CONCLUSIONS: QOL of glaucoma patients was lower than that of normal persons without glaucoma considering sex, age, health insurance system, family history of glaucoma, past history of systemic disease, educational level, marital status, smoking status, drinking status and visual acuity, so further study will be necessary to observe the change of QOL according to progression of glaucoma and treatment status.
Drinking ; Glaucoma* ; Health Surveys ; Humans ; Insurance ; Insurance, Health ; Marital Status ; Ophthalmology ; Quality of Life* ; Surveys and Questionnaires ; Smoke ; Smoking ; Visual Acuity

BACKGROUND: The choice of anesthetic agents and adjuvants during outpatient surgery is of critical importance. Propofol is widely used for the induction and maintenance of outpatient anesthesia. Because propofol lacks analgesic properties, very high concentrations may be required when propofol is used as the sole anesthetic drug. Propofol is used with adjuvants such as nitrous oxide or opioid. This study was designed to evaluate the intraoperative hemodynamic response, recovery characteristics and side effects of propofol-fentanyl anesthesia compared with propofol-N2O anesthesia for outpatient surgery. METHODS: Twenty six healthy and unpremedicated patients scheduled for outpatient surgery were randomly allocated to receive either propofol-N2O anesthesia (N-group) or propofol-fentanyl anesthsia (F-group). The patients in N-group were ventilated with nitrous oxide 60~70% in oxygen and the patients in F-group were ventilated with oxygen 40% in nitrogen via laryngeal mask airway (LMA). RESULTS: There was no significant difference in blood pressure during anesthesia, recovery time and side effects between two group. There was significant decrease of heart rate in F-group. CONCLUSION: We concluded that nitrous oxide and fentanyl are reasonable adjuvants of propofol anesthesia in outpatient anesthesia.
Ambulatory Surgical Procedures* ; Anesthesia* ; Anesthetics ; Blood Pressure ; Fentanyl ; Heart Rate ; Hemodynamics ; Humans ; Laryngeal Masks ; Nitrogen ; Nitrous Oxide ; Outpatients* ; Oxygen ; Propofol

PURPOSE: To investigate the changes in tear flow and tear filim stability in patients with long-term instillation of antiglaucoma drug. METHODS AND OBJECTS: We measured Schirmer test score and tear film break-up time (BUT) in long-term antiglaucoma drug instilling 60 patients (120eyes) who had been diagnosed with open angle glaucoma and in randomly selected 60 normal subjects (120eyes) from March 2000 to February 2001 at Chosun University Hospital. Obtained results were retrospectively analyzed with the age progression and sex of subjects, duration of instillation, number and type of drugs to find out correlations between these factors. RESULTS: Average Schirmer test score and BUT were measured considerably lower in antiglaucomat drug instilled group compared to normal-subjects group (P<0.05, student t-test). Both measurements considerably decreased as age of patients and drug instillation time increased (P<0.05, ANOVA test). But number and type of instilled drugs had no considerable correlation to the obtained results (P>0.05, ANOVA test). CONCLUSIONS: It should be predicted that the patients who had instilled antiglaucoma drug for a long time and who are also of old age may develop dry eye syndrome and eye surface problem. So special care should be taken with glaucoma treatment in such cases.
Dry Eye Syndromes ; Glaucoma ; Glaucoma, Open-Angle ; Humans ; Instillation, Drug* ; Retrospective Studies ; Tears*

No abstract available.
Malaria* ; Plasmodium vivax* ; Plasmodium*

In order to investigate the factors associated with family burdens of schizophrenics, 92 primary caregivers and 68 siblings of 92 persons with schizophrenia were examined by means of self-report scales about the effect of positive and negative symptom behaviors, clinical and sociodemographic variables, and guilty feelings toward patient on the objective and subjective burden. The results were as follows. 1) There was no difference in the objective and subjective burden scores between the primary caregivers and siblings, even though the former showed a higher scores compared to the latter. 2) Burden scores were significantly affected by the factors such as age of patients, duration of illness, total duration of hospitalizations, monthly family income, and the experience of family education in the primary caregivers or siblings of schizophrenics. 3) Objective and subjective burden were related to both the severity of positive, negative, and the other symptom behaviors in the primary caregivers and siblings. The positive and negative symptom behaviors were more related to subjective burdens compared to objective burdens in the primary caregivers and siblings. The positive symptom behaviors were more related to perceived objective and subjective burdens compared to negative symptom behaviors in the siblings. 4) The correlations between guilty feelings toward patient and burden scores was significant only in the primary caregivers. These results could be used as useful datas to develop the more effective family intervention for reducing family burden.
Caregivers* ; Education ; Hospitalization ; Humans ; Schizophrenia ; Siblings* ; Weights and Measures