1.Clinical evaluation of severe ovarian hyperstimulation syndrome.
Seok Hyun KIM ; Byoung Gie KIM ; Chung Hoon KIM ; Chang Jae SHIN ; Jung Gu KIM ; Shin Yong MOON ; Jin Yong LEE ; Yoon Seok CHANG
Korean Journal of Obstetrics and Gynecology 1992;35(6):860-872
No abstract available.
Female
;
Ovarian Hyperstimulation Syndrome*
2.Single-port access laparoscopic staging operation for a borderline ovarian tumor.
Aera YOON ; Tae Joong KIM ; Woo Seok LEE ; Byoung Gie KIM ; Duk Soo BAE
Journal of Gynecologic Oncology 2011;22(2):127-130
Minimally invasive surgery is widely used in benign gynecologic diseases and may be used in malignancies. We performed a single-port access laparoscopy staging - bilateral salpingo-oophorectomy, laparoscopy-assisted vaginal hysterectomy, bilateral pelvic lymphadenectomy, infracolic omentectomy, and washing cytology - in a borderline ovarian tumor. The number of harvested pelvic lymph nodes were twenty-three and there were no intraoperative or postoperative complications. Single-port access laparoscopic staging may be performed in selected patients. The efficacy, safety, and potential benefits of this technique should be evaluated in further trials.
Female
;
Genital Diseases, Female
;
Humans
;
Hysterectomy, Vaginal
;
Laparoscopy
;
Lymph Node Excision
;
Lymph Nodes
;
Postoperative Complications
3.Umbilical artery doppler velocimetry and fetal biometry.
Seong Chan PARK ; Cheol Ho KIM ; Jeong Hun CHOI ; Young Mi LEE ; Hee Sub RHEE ; Bu Kie MIN ; Gie Seok KIM
Korean Journal of Perinatology 1993;4(3):363-370
No abstract available.
Biometry*
;
Rheology*
;
Umbilical Arteries*
4.Long-term recurrence-free survival in a patient with stage IVB uterine carcinosarcoma.
Gun YOON ; Yong Seok KIM ; Byoung Gie KIM ; Duk Soo BAE ; Jeong Won LEE
Journal of Gynecologic Oncology 2011;22(4):292-294
Uterine carcinosarcomas are rare and highly aggressive tumors with a poor prognosis. Due to early metastasis and disease progression, it is known to be far more aggressive than matched grade 3 endometroid endometrial carcinomas. Five-year survival for stage IV is reported to be 10% and overall survival for stage IVB is expected to be very poor. The authors report one case after experiencing long-term survival (over 5 years) for stage IVB carcinosarcoma of uterus. Total abdominal hysterectomy and bilateral salpingo-oophorectomy was performed to 56 year old patient for uterine myoma. On pathology report, uterine carcinosarcoma was diagnosed and image studies were performed. With the impression of stage IVB uterine carcinosarcoma, 6 cycles of chemotherapy (ifosfamide and cisplatin) was conducted as adjuvant. Up to recently (over 5 years), she maintains good performance scale without evidence of tumor recurrence or disease progression.
Carcinosarcoma
;
Disease Progression
;
Endometrial Neoplasms
;
Female
;
Humans
;
Hysterectomy
;
Myoma
;
Neoplasm Metastasis
;
Prognosis
;
Recurrence
;
Uterus
5.Changes in Pulmanary Gas Exchange during General Anesthesia for Laparoscopic Cholecystectomy.
Ik Hyun CHOE ; Myoung Gie HONG ; Hoon KANG ; Hye Kyung KIM ; Yong Seok OH
Korean Journal of Anesthesiology 1993;26(1):137-140
The recent development of laparoscopic cholecysteetomy has introduced the technique of laparoscopy to the general surgical operation. During this procedure, the deliberate pneumoperitoneum with carbon dioxide(CO2) insufflation in order to visualize better the abdominal viscera may causes some problems-hypercarbia, hypertension, pneumomediastinum, subcutaneous emphysema and cardiovascular impairment, We studied the changes of cardiovascular system and pulmonary gas exchanges clinically during general anesthesia for laparoscopic eholecystectomy in the 16 patients of Seoul National University Hospital. After induction of anesthsia, ventilation was controlled with tidal volume 10 ml/kg and respiration rate 10-15/min to maintain PaCO2 35 mmHg before insufflation of carbon dioxide. After measuring of control value of mean arterial pressure(MAP), heart rate(HR) and arterial blood gas analysis before insufflation of CO2, ventilation setting was not changed throughout the operation. MAP, HR, arterial blood gas analysis were measured at 30 min interval until the end of operation. The changes of MAP, HR and PaO2, throughout the operation are not statistically significant in comparison to control(preinsufflation) values. The PaCO2 was increased significantly by 8-10 mmHg in comparison to control values(p-value<0.01). In conclusion, minute ventilation should be corrected during general anesthesia for laparoscapic cholecysteetomy with CO2 insufflation according to continuous monitoring of end tidal CO2 and arterial carbon dioxide tension.
Anesthesia, General*
;
Blood Gas Analysis
;
Carbon
;
Carbon Dioxide
;
Cardiovascular System
;
Cholecystectomy, Laparoscopic*
;
Heart
;
Humans
;
Hypertension
;
Insufflation
;
Laparoscopy
;
Mediastinal Emphysema
;
Pneumoperitoneum
;
Respiratory Rate
;
Seoul
;
Subcutaneous Emphysema
;
Tidal Volume
;
Ventilation
;
Viscera
6.Laparoscopic-assisted vaginal hysterectomy versus abdominal hysterectomy in patients with early stage endometrial cancer.
Min Kyu KIM ; Dong Seok CHOI ; Woo Young KIM ; Chel Hun CHOI ; Tae Joong KIM ; Jeong Won LEE ; Byoung Gie KIM ; Je Ho LEE ; Duk Soo BAE
Korean Journal of Obstetrics and Gynecology 2006;49(12):2583-2588
OBJECTIVE: To compare laparoscopic surgery with conventional abdominal surgery in patients with early stage endometrial cancer. METHODS: A retrospective review of 63 patients with early stage endometrial cancer managed between March 2003 and May 2005. Two groups were defined whether they had been treated by laparoscopy (case group: n=26) or by laparotomy (control group: n=37). We compared age, body mass index (BMI), hemoglobin change, operation time, number of pelvic lymph nodes, hospital stay, case with adjuvant treatment and recurrence between two groups. RESULTS: There was no statistical difference in characteristics (age, BMI, nulliparity, previous abdominal surgery, FIGO stage, histologic grade). between case and control group. In addition, there was no statistical difference in operation data and outcomes between two groups. Hemoglobin changes were 1.1 g/dL (case group) vs 1.7 g/dL (control group) (p=0.072). Operation time was 131 min vs. 115 min. The numbers of lymph nodes obtained were 8.7 vs 7.7 (right) 9.2 vs. 7.6 (left). Hospital stays were 8.4 vs. 9.2 days. Adjuvant treatment cases were 7 vs. 15. Recurrent case was one in each group. Two patients initially evaluated by laparoscopy were converted to laparotomy due to bleeding and adhesion. CONCLUSION: Laparoscopic surgery for treatment of early endometrial cancer is a safe and effective alternative to laparotomy . However, long-term survival and risk of recurrence have yet to be determined.
Body Mass Index
;
Endometrial Neoplasms*
;
Female
;
Hemorrhage
;
Humans
;
Hysterectomy*
;
Hysterectomy, Vaginal*
;
Laparoscopy
;
Laparotomy
;
Length of Stay
;
Lymph Nodes
;
Parity
;
Recurrence
;
Retrospective Studies
7.Controversies in the management of endometrial cancer: a survey of the Korean Gynecologic Oncology Group.
Jung Yun LEE ; Kidong KIM ; Taek Sang LEE ; Sokbom KANG ; Seok Ju SEONG ; Jae Weon KIM ; Byoung Gie KIM
Journal of Gynecologic Oncology 2015;26(4):277-283
OBJECTIVE: To identify current practice patterns for unresolved issues in the surgical and adjuvant management of endometrial cancer in Korea. METHODS: We designed and conducted a survey of all 218 active members of the Korean Gynecologic Oncology Group to try to identify how they would manage various case scenarios for endometrial cancer. Data were collected using an Internet survey database. RESULTS: A total of 108 members (49.5%) responded to the survey. Laparoscopy (81.6%) was the most commonly used mode of surgery in early-stage endometrial cancer. Of all the respondents, 19.8% stated that lymphadenectomy could be omitted and 21.7% recommended selective lymphadenectomy based on sentinel biopsy or frozen results for patients with presumed stage IA/grade 1 disease. On the other hand, 71.9% of respondents recommended para-aortic lymphadenectomy for patients with presumed stage IB/grade 1 disease and 86.4% recommended this treatment for presumed stage IB/grade 3 disease. The majority of respondents performed adjuvant therapy for stage IB/grade 2 (91.7%), IB/grade 3 (99.0%), and stage II (89.6%). Whole pelvic radiotherapy and vaginal brachytherapy were the most frequently used options among these patients. All respondents administered adjuvant therapy when node metastasis was found, and concurrent chemoradiotherapy (53.2%) was the most preferred option for stage IIIC1 disease. CONCLUSION: There is broad variation in both the surgical and adjuvant treatment of endometrial cancer among Korean gynecologic oncologists.
Adult
;
Combined Modality Therapy
;
Endometrial Neoplasms/pathology/*therapy
;
Female
;
*Gynecology
;
Humans
;
Incidental Findings
;
Lymph Node Excision/methods
;
Lymphatic Metastasis
;
Magnetic Resonance Imaging/methods
;
Male
;
Middle Aged
;
Neoadjuvant Therapy
;
Personal Satisfaction
;
Practice Patterns, Physicians'
;
Republic of Korea
;
Robotic Surgical Procedures
8.Early Metabolic Response Assessed Using 18F-FDG-PET/CT for Image-Guided Intracavitary Brachytherapy Can Better Predict Treatment Outcomes in Patients with Cervical Cancer
Nalee KIM ; Won PARK ; Won Kyung CHO ; Duk-Soo BAE ; Byoung-Gie KIM ; Jeong-Won LEE ; Tae-Joong KIM ; Chel Hun CHOI ; Yoo-Young LEE ; Young Seok CHO
Cancer Research and Treatment 2021;53(3):803-812
Purpose:
This study aimed to identify the prognostic value of early metabolic response assessed using 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) during radiation therapy (RT) for cervical cancer.
Materials and Methods:
We identified 116 patients treated with definitive RT, including FDG-PET/CT–guided intracavitary brachytherapy, between 2009 and 2018. We calculated parameters including maximum (SUVmax) and mean standardized uptake values (SUVmean), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) for baseline FDG-PET/CT (PETbase) and image-guided brachytherapy planning FDG-PET/CT (PETIGBT). Multivariable analyses of disease-free survival (DFS) and overall survival (OS) were performed.
Results:
We observed a time-dependent decrease in PET parameters between PETbase and PETIGBT; ΔSUVmax, ΔSUVmean, ΔMTV, and ΔTLG were 65%, 61%, 78%, and 93%, respectively. With a median follow-up of 59.5 months, the 5-year DFS and OS rates were 66% and 79%, respectively. Multivariable analysis demonstrated that ΔSUVmax ≥ 50% was associated with favorable DFS (hazard ratio [HR], 2.56; 95% confidence interval [CI], 1.14 to 5.77) and OS (HR, 5.14; 95% CI, 1.55 to 17.01). Patients with ΔSUVmax ≥ 50% (n=87) showed better DFS and OS than those with ΔSUVmax < 50% (n=29) (DFS, 76% vs. 35%, p < 0.001; OS, 90% vs. 41%, p < 0.001, respectively). Adenocarcinoma was frequently observed in ΔSUVmax < 50% compared to ΔSUVmax ≥ 50% (27.6% vs. 10.3%, p=0.003). In addition, models incorporating metabolic parameters showed improved accuracy for predicting DFS (p=0.012) and OS (p=0.004) than models with clinicopathologic factors.
Conclusion
Changes in metabolic parameters, especially those in SUVmax by > 50%, can help improve survival outcome predictions for patients with cervical cancer treated with definitive RT.
9.Early Metabolic Response Assessed Using 18F-FDG-PET/CT for Image-Guided Intracavitary Brachytherapy Can Better Predict Treatment Outcomes in Patients with Cervical Cancer
Nalee KIM ; Won PARK ; Won Kyung CHO ; Duk-Soo BAE ; Byoung-Gie KIM ; Jeong-Won LEE ; Tae-Joong KIM ; Chel Hun CHOI ; Yoo-Young LEE ; Young Seok CHO
Cancer Research and Treatment 2021;53(3):803-812
Purpose:
This study aimed to identify the prognostic value of early metabolic response assessed using 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) during radiation therapy (RT) for cervical cancer.
Materials and Methods:
We identified 116 patients treated with definitive RT, including FDG-PET/CT–guided intracavitary brachytherapy, between 2009 and 2018. We calculated parameters including maximum (SUVmax) and mean standardized uptake values (SUVmean), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) for baseline FDG-PET/CT (PETbase) and image-guided brachytherapy planning FDG-PET/CT (PETIGBT). Multivariable analyses of disease-free survival (DFS) and overall survival (OS) were performed.
Results:
We observed a time-dependent decrease in PET parameters between PETbase and PETIGBT; ΔSUVmax, ΔSUVmean, ΔMTV, and ΔTLG were 65%, 61%, 78%, and 93%, respectively. With a median follow-up of 59.5 months, the 5-year DFS and OS rates were 66% and 79%, respectively. Multivariable analysis demonstrated that ΔSUVmax ≥ 50% was associated with favorable DFS (hazard ratio [HR], 2.56; 95% confidence interval [CI], 1.14 to 5.77) and OS (HR, 5.14; 95% CI, 1.55 to 17.01). Patients with ΔSUVmax ≥ 50% (n=87) showed better DFS and OS than those with ΔSUVmax < 50% (n=29) (DFS, 76% vs. 35%, p < 0.001; OS, 90% vs. 41%, p < 0.001, respectively). Adenocarcinoma was frequently observed in ΔSUVmax < 50% compared to ΔSUVmax ≥ 50% (27.6% vs. 10.3%, p=0.003). In addition, models incorporating metabolic parameters showed improved accuracy for predicting DFS (p=0.012) and OS (p=0.004) than models with clinicopathologic factors.
Conclusion
Changes in metabolic parameters, especially those in SUVmax by > 50%, can help improve survival outcome predictions for patients with cervical cancer treated with definitive RT.
10.Changes in expression of cell cycle regulators after G1 progression upon repetitive thioacetamide treatment in rat liver.
Sook Hee HONG ; Gie Deug LEE ; Jun Young CHUNG ; Kyung Sook CHO ; Seok Hee PARK ; In Hoo KIM ; Jin Sook JEONG
Experimental & Molecular Medicine 2002;34(5):361-366
Repetitive low dose thioacetamide (TA) treatment of hepatocytes was found to induce cells in G2 arrest. In the present study, an attempt was made to investigate alterations in expression of cell cycle regulators after G1 progression in the same repetitive low dose TA treated hepatocytes system and to define the determinators involved in G2 arrest. TA was daily administered intraperitoneally, with a dose of 50 mg/kg for 7 days. Expression levels of cyclin E and CDK2 were similar, increased at day 1 and reached a peak at day 2. And they recycled from day 3 reaching a second peak at day 5. Expression level of cyclin A was similar to p27(Kip1) and p57(Kip2) but not to CDK2 and increased to a peak level at day 2. Expression levels of cyclin B1 and cdc2 were similar although the cyclin B1 level was generally low, decreased from day 1 to basal levels at day 3 and persisted at a low level till day 7. The expression level of cyclin G1 was similar to p53 that peaked at day 3 and again at day 6 elevated over basal level. BrdU-labeled hepatocytic nuclei increased from 12 h, reached a peak at day 2, then decreased, and were not detectable from day 6. The number of PCNA-labeled nuclei increased immediately, peaked at day 2, and maintained till day 7. These results suggest that G2 arrest induced by repeated TA treatment might be p53-dependent, via activation of cyclin G1, rather than inhibition of cyclin B1- cdc2 complex, and inhibitors holding S phase progression might be p27(Kip1) and p57(Kip2).
Animals
;
Bromodeoxyuridine/metabolism
;
CDC2 Protein Kinase/drug effects/metabolism
;
*CDC2-CDC28 Kinases
;
Cell Cycle/drug effects/*physiology
;
Cell Cycle Proteins/drug effects/metabolism
;
Cyclin-Dependent Kinases/antagonists & inhibitors/drug effects/metabolism
;
Cyclins/drug effects/metabolism
;
Dose-Response Relationship, Drug
;
G1 Phase/drug effects/*physiology
;
Liver/*drug effects/pathology
;
Male
;
Nuclear Proteins/drug effects/metabolism
;
Proliferating Cell Nuclear Antigen/metabolism
;
Protein p53/metabolism
;
Protein-Serine-Threonine Kinases/antagonists & inhibitors/drug effects/metabolism
;
Rats
;
Rats, Sprague-Dawley
;
Thioacetamide/administration & dosage/*pharmacology
;
Tumor Suppressor Proteins/drug effects/metabolism