This clinical & histopathological study was performed with 48 cases of cutaneous tuberculoeis among 44460 cases of out patient in Dermatologic clinc of St. Mary's hospital, Catholic Medical College, from 1970 to l974. These 48 cases were consistent with skin tuberculosis in histological and clinical findings. The results are follows. I. Clinieal observation. 1) The incidence of skin tuberculosis is 0. 1%, among 44460 cases of out patients. 2) Localized type of skin tuberculosis is l. 4 times more than disseminated type. 3) The ratio between male and female is 2. 4: l. 4) The age of onset is different from type to type, but 70. 8% of all cases occured before the age of 29. 5) Common skin tuberculosis is Erythema induratum (31. 3%),Lupus Vulgaris (20.8%) and Papulonerotic tuberculid (12.5%)II. Histopathological observation. 1) Only 12. 5% of the cases showes typical structure of tubercle in dermis and subcutis. 2) Caseation necrosis showes in 47% and their amounts are different between the types. 3) About 75% of cases showes Langhans giant cells but some of the cases show foreign body giant cells in tubercle or tuberculoid structures. 4) Vessels are involved in all of the cases. Main changes are wall proliferation, degeneration and perivascular infiltration. 5) A.F.B. stain showes negative in all cases.
Age of Onset ; Dermis ; Erythema Induratum ; Female ; Giant Cells, Foreign-Body ; Giant Cells, Langhans ; Humans ; Incidence ; Male ; Necrosis ; Outpatients ; Skin* ; Tuberculosis, Cutaneous*

No abstract available.
Dextrans ; Giant Cells ; Granuloma, Foreign-Body

Recently, we have experienced two cases of xanthogranuloma in adults presenting either a solitary papule or multiple papules. Laboratory findings including blood lipid substances such as cholesterol and triglyceride were within normal limits. In both cases, we could not find any other extracutaneous manifestations. Granulomatous infiltrates containing foam cells, foreign body giant cells and Touton giant cells as well as histiocytes and lymphocytes were revealed by histopathologic findings.
Adult* ; Cholesterol ; Foam Cells ; Giant Cells ; Giant Cells, Foreign-Body ; Histiocytes ; Humans ; Lymphocytes ; Triglycerides

Juvenile xanthogranuloma (JXG) is a benign self-limited histiocytic proliferative disorder that usually occurs in early childhood. JXG appears as reddish to yellow, papules, or nodules, and although the head, neck, and trunk are the most frequent locations, it can occur at any body site. However, JXG involving the finger is rare. Histologically, JXG is characterized by an ill-defined, unencapsulated, dense histiocytic infiltrate within the dermis, some of which is contained in Touton giant cells, foreign body giant cells and foamy cells. Because the cutaneous lesions spontaneously regress, treatment is not usually indicated. The authors report a case of JXG in a 4-year-old girl who had tender, yellowish papule on the ventral aspect of the MCP joint of the right fourth finger consistent with JXG.
Dermis ; Fingers ; Giant Cells ; Giant Cells, Foreign-Body ; Head ; Joints ; Neck ; Preschool Child ; Xanthogranuloma, Juvenile

We studied the foregin body reaction to the implanted intraocular lens(IOL) and IOL acceptance in the patient's eye by biomicroscopic examination of precipitates on the IOL surface in 432 cases. We divided the cellular and pigment precipitates of the posterior chamber lens(PCL) showed grade 3 until seven days postoperative and then slowly decreased; but, that of the anterior chamber lens(ACL) persisted a little longer. Pigment precipitates on ACL was less than that of PCL, and pigment precipitates stayed longer than cellular precipitates. Round, bipolar small cellular precipitates seem to be identical to fibroblast-like cells, and large, irregular shaped cellular precipitates seem to be foreign body giant cells. A large number of foreign body giant cells precipitated and persisted longer in cases of prolonged postoperative inflammation.
Anterior Chamber ; Giant Cells, Foreign-Body ; Inflammation ; Lenses, Intraocular*

We studied the foregin body reaction to the implanted intraocular lens(IOL) and IOL acceptance in the patient's eye by biomicroscopic examination of precipitates on the IOL surface in 432 cases. We divided the cellular and pigment precipitates of the posterior chamber lens(PCL) showed grade 3 until seven days postoperative and then slowly decreased; but, that of the anterior chamber lens(ACL) persisted a little longer. Pigment precipitates on ACL was less than that of PCL, and pigment precipitates stayed longer than cellular precipitates. Round, bipolar small cellular precipitates seem to be identical to fibroblast-like cells, and large, irregular shaped cellular precipitates seem to be foreign body giant cells. A large number of foreign body giant cells precipitated and persisted longer in cases of prolonged postoperative inflammation.
Anterior Chamber ; Giant Cells, Foreign-Body ; Inflammation ; Lenses, Intraocular*

Juvenile Xan anuloma is granulomatous, benign disseminated Xanthomatous disease, which i r cytosis of unknown origin, due to lipid, metabolism disturbance. Spontaneous remi. is possible authors have reported some cases of JXG involving only skin or combii extracutaneous lesions, In our country, cases involving onIy skin have bcen reported. This I-year-old norered healthy male baby has yellowish brown coloxed pinhead to rice sizeci gers of well defined. round, dome shaped smooth surface in face, trunk, lower abdomen without any subjective symptomes. Serum lipid level i iid chest p-A,urinalysis, CBC, L.F.T. are normal. Family history showed ific finding and physical examina.tion shows nothing remarkable except for skeen lesions. EIistopathologically, hi;tiocyte, lymphocyte, eosinophile, foam cell, foreign body giant cell, typical Toutor giant cell are seen.
Abdomen ; Eosinophils ; Foam Cells ; Giant Cells ; Giant Cells, Foreign-Body ; Humans ; Lymphocytes ; Male ; Metabolism ; Skin ; Thorax ; Xanthogranuloma, Juvenile*

BACKGROUND: Pilomatricoma is a rare benign follicular tumor in Asians OBJECTIVE: purpose of this study was to assess the clinical and histopathological features of the tumor. METHODS: The hospital charts and slides of 13 patients with pilomatricoma over a 12-year period at Ewha Womans University Tongdaemun Hospital were retrospectively reviewed. RESULTS: The age of patients ranged from 5 to 76 years with a mean of 21.5 years. The maleto-female ratio was 1:3.3. Seventy-seven percent of the tumors were located on the upper and lower extremities, followed by the face and neck. Most tumors appeared as a pea-sized hard movable skin-colored nodule. At histopathologic level, the most common morphological stage was the early regressive stage (stage 3), followed by late regressive (stage 4), fully developed (stage 2), and early (stage 1) stages. Foreign body giant cells, calci6cation, ossification were seen in 69.2%, 84.6%, and 7.7%, respectively; giant cells and inflammatory infiltrate were mostly seen in stage 3 tumors, calcification in stage 3 and 4 tumors, and ossification, only in the sole stage 4 tumor. Anetodermic changes of overlying dermis were seen in 2 cases (15.4%). CONCLUSION: The various histopathologic features of pilomatricoma can be explained by its chronological, morphological stages.Most pilomatricomas present for longer than 6 months are already in stage 3, and one can expect the histopathological features accordingly.
Asian Continental Ancestry Group ; Dermis ; Female ; Giant Cells ; Giant Cells, Foreign-Body ; Humans ; Lower Extremity ; Neck ; Pilomatrixoma* ; Retrospective Studies

PURPOSE: To analyze the results of the foreign body reaction to polyethylene, polymethylmethacrylate, and metal debris and effect on bone by comparing histopathologic finding of pseudomembrane (interface membrane) which was obtained from failed cemented or cementless THA by aseptic loosening. MATERIALS AND METHODS: Of total 50 cases, we analyzed results between 25 cases of cemented THA and 25 cases of cementless THA. Follow-up period between primary and revision THA was average 8 years 5 months. Tissue specimens were harvested, stained with Hematoxylin-Eosin, and examined by light microscope. Histologic study of various items was done. RESULTS: The fibrous membrane between bone-to-cement or bone-to-metal could be roughly divided into three distinct histological layers in cross section histopathology. These tissues were characterized by histiocytes, infiltration of foreign body giant cells and fibrosis in all specimens, and infiltration of lymphocytes and plasma cells was relatively rare, and aggregation of polymorphonuclear leukocytes was invisible. CONCLUSION: Although there were no significant differences in histologic findings between the regions of ten tissue specimens, there was significant difference between the degree of polyethylene or cement debris in numbers and the degree of foreign body reaction associated with increased infiltrations of giant cells, and foreign body reaction to polyethylene debris seems to be main cause of aseptic loosening of prosthesis.
Arthroplasty, Replacement, Hip* ; Fibrosis ; Follow-Up Studies ; Foreign-Body Reaction ; Giant Cells ; Giant Cells, Foreign-Body ; Histiocytes ; Lymphocytes ; Membranes ; Neutrophils ; Plasma Cells ; Polyethylene ; Polymethyl Methacrylate ; Prostheses and Implants

Frontal sinusitis can lead to severe and life-threatening disorders. Complications may involve intracranial structures, orbit and adjacent bone and soft tissue structures. Bone wax has been used since the turn of the century as a mechanical aid to hemostasis following surgical procedures. That it may produce a foreign body giant cell reaction in significant proportion of cases is well known. We experienced a woman who had recurrent frontal sinusitis due to bone wax. She was treated by endoscopic frontal sinusotomy with foreign body removal.
Female ; Foreign Bodies ; Frontal Sinus* ; Frontal Sinusitis* ; Giant Cells, Foreign-Body ; Hemostasis ; Humans ; Orbit