Foot ; pathology ; Giant Cell Tumors ; diagnosis ; Humans ; Tendons ; pathology

Osteoclast-like giant cell tumor of the pancreas is a very rare tumor. Despite their striking morphologic resemblance to certain mesenchymal tumors of bone and tendon sheath, it has been suggested that these tumors may arise from epithelial precursors. This unusual tumor presents in the 6th or 7th decade with a nearly equal gender ratio. Pure forms of osteoclast-like giant cell tumor have a better prognosis because they have a predilection to local spread, are slower to metastasize and rarely metastasize to lymph nodes, but these forms are very rare. We present an osteoclast-like giant cell tumor arising in the body of the pancreas in a 71 year-old male patient. The tumor was composed of two major cell types: atypical mononuclear cells and abundant osteoclast-like multinucleated giant cells. Immunohistochemical studies showed that atypical cells were strongly reactive for vimentin and focally reactive for cytokeratin. In contrast, the giant cells were immunoreactive for CD68, but negative for cytokeratin. Three months later, the tumor size increased and liver metastasis was newly developed. He died at 11 months after the diagnosis.
Aged ; Giant Cell Tumors/*pathology ; Humans ; Male ; Osteoclasts/*pathology ; Pancreatic Neoplasms/*pathology

Bone Neoplasms ; pathology ; Female ; Giant Cell Tumors ; pathology ; Humans ; Middle Aged ; Petrous Bone ; pathology

The authors report a typical case of tenosynovial giant cell tumor of the right middle finger of a 31-year-old man. Histologically, this tumor is characterized by a discrete proliferation of rounded synovial-like cells accompanied by a variable number of multinucleated giant cells, inflammatory cells, and xanthoma cells. Clinicopathologically, this tumor is a benign lesion that nonetheless possesses a capacity for local recurrence. Local excision with a small cuff of normal tissue is the treatment of choice in this tumor.
Adult ; Case Report ; Fingers* ; Giant Cell Tumors/surgery ; Giant Cell Tumors/pathology* ; Histocytochemistry ; Human ; Male ; Muscle Neoplasms/surgery ; Muscle Neoplasms/pathology* ; Neoplasm Recurrence, Local ; Synovial Membrane/pathology*

Localized forms of giant cell tumor are known to arise commonly in the synovial membrane of the finger joints. Multinucleated giant cells are its characteristic pathology finding, giant cell tumor shows a low rate of recurrence after complete excision. When occurring at the knee joints, giant cell tumor manifests a wide form of symptoms, from no symptom at all, to intermittent locking. Complete excision is possible by arthroscopy, but if done incompletely, it is reported to recur in 45% of cases. We present here a case of giant cell tumor that has arisen from the anterior portion of the posterior cruciate ligament, excised by arthroscopy and followed by pathologic confirmation.
Arthroscopy ; Finger Joint ; Giant Cell Tumors* ; Giant Cells ; Knee Joint* ; Pathology ; Posterior Cruciate Ligament* ; Recurrence ; Synovial Membrane

PURPOSE: Giant cell tumor is the second most common benign neoplasm in upper extremity. Unlike usual chief complaint of painless mass, an atypical case with giant cell tumor presented a distinguishing characteristics of which accompany pain and tenderness and is histologically giant-cell free. METHODS: A 31-year-old male patient complained of a rapid growing painful mass on the proximal phalanx of the left ring finger. Under microscopic operation, a 1.6 x 1.3cm sized mass was found to be surrounded by areolar tissue and attached to a tendon sheath, encircling the digital nerve and artery. Diagnostic confirmation was assisted by positive finding in histologic immunohistochemical stain-CD68. Characteristic pathologic finding is an atypical distribution of spindle cells & histiocytes without giant cells in fascicular pattern. RESULTS: Giant cell tumor was carefully removed under microscopic approach, while preserving digital nerve & artery. In postoperative 13th month, the patient presented with a 6mm of static two-point discrimination test, similar to that of the adjacent fingers. CONCLUSION: We report an atypical case with painful mass on tendon sheath, surrounding the digital nerve and artery that was diagnosed of giant cell tumor, but without giant cells on pathology. This case provides broader understanding of the giant cell tumor that should not only rely its typical findings of the painless mass and positive sign on H&E stain.
Adult ; Arteries ; Discrimination (Psychology) ; Fingers ; Giant Cell Tumors* ; Giant Cells* ; Histiocytes ; Humans ; Male ; Pathology ; Tendons ; Upper Extremity

Adult ; Elbow ; Giant Cell Tumors ; diagnosis ; pathology ; physiopathology ; surgery ; Humans ; Magnetic Resonance Imaging ; Male ; Tendons

Adult ; Bone Neoplasms ; Female ; Giant Cell Tumors ; Humans ; Temporal Bone ; pathology

Giant cell tumors are distinctive neoplasms characterized by a profusion of multinucleate giant cells scattered throughout a stroma of mononuclear cells. Most giant cell tumors are found at the epiphyses of long bones, especially around the knee joint. Flat bone involvement is rare. However, a case of giant cell tumor with secondary aneurysmal bone cyst was encountered at the scapula of a 25-year-old man. Since the occurrence of a giant cell tumor with secondary aneurysmal bone cyst on flat bones (i.e., the scapula) is extremely rare, the above-mentioned case is worthy of reporting.
Adult ; Bone Cysts/*etiology/pathology ; Bone Neoplasms/*complications/pathology ; Giant Cell Tumors/*complications/pathology ; Humans ; Male ; Scapula

Adult ; Angiofibroma ; chemistry ; pathology ; Giant Cell Tumors ; chemistry ; pathology ; Humans ; Laryngeal Neoplasms ; chemistry ; pathology ; Male ; Middle Aged ; Vocal Cords