31 compounds (mainly sesquiterpenoids) were identified in the composition of the wood oil of Fokienia hodginsii (Dunn) Hery et Thomas, Cupressaceae, of Vietnam. Trans nerolidol (35.0%) and fokienol (25.2%) are the major constituents of the oil. A novel oxygenated sesquiterpen, farnesa-1, 8, 10-trien -3,7-oxide was isolated from the oil, their structure were characterized by MS, 1H- and 13C-NMR. For the first time, the antibacterial and antifungal activity against 15 microorganisms of the oil as well as the isolated sesquiterpenoids trans nerolidol, fokienol and a-cadinol was studied.
Anti-Bacterial Agents ; Antifungal Agents

Leaves of Pseuderanthemum palatiferum (Nees) Radlk., Acanthaceae, was traditionally used to treat various diseases, including digestive disorders, spastic colitis, stomach ache, traumatic bleeding, kidney and liver diseases. The extract of ethyl acetate and n-butanol soluble fractions (accounted for 1% of the dry material) were prepared from the leaves of P. palatiferum as the flavonoid-enriched fractions. The antioxidant activities of the flavonoid-enriched fractions were evaluated by their influences on the activities of the blood peroxidase. The results demonstrated that antioxidant activities of flavonoid-enriched fractions were depended on blood groups and had potent, selective effects. Moderate (of n-butanol fraction) to strong antibacterial activity (of ethyl acetate fraction) and insignificant antifungal activity (of both ethyl acetate and n-butanol fractions) against ten bacteria strains and two fungi Candida albicans and Candida stellatoides were observed using standard disc diffusion method. Strong sensitivity of Salmonella typhi 158, Shigella flexneri and Escherichia coli to the ethyl acetate fraction was noteworthy. The results showed the probable involvement of the flavonoids in the antioxidant and antibacterial activities of the ethyl acetate and n-butanol soluble fractions from the leaves of Pseuderanthemum palatiferum
Flavonoids ; Antioxidants ; Anti-Bacterial Agents ; Antifungal Agents

Chemico botanical properties and antibiotic – antifingal activities of machilus bonii. From methanol extract of the bark of Machilus bonii, dotriacontanoic acid, palmitic acid, betasitosterol were isolated and indentified. The esters of saturated and unsaturated carboxylic acids, ketones, anhydrids and hydrocarbones together with sesquiterpene hydrocarbone as major volalile constituent were revealed antibacterial and antifungal activities of n-hexane, ethylacetate and n-butanol soluble fractions were determined, the properties against Psendomonas aeruginosa, cherichiacoli and candida albicany
Medicine, Traditional ; Anti-Bacterial Agents ; Antifungal Agents ; Pharmaceutical Preparations

Background: Preeclampsia is a complex disease caused by pregnancy, with many complications for both mother and fetus, but there is no specific treatment. The purpose of the study is to describe clinical characteristics and survey some risk factors for preeclampsia. Materials and methods: The case-control study included 205 pregnant women with preeclampsia and 205 pregnant women without preeclampsia. Results: In the preeclampsia group, systolic blood pressure, diastolic blood pressure and BMI were 154.9 ± 15.5 mmHg, 96.0 ± 9.7 mmHg and 23.7 ± 3.5 kg/m2, respectively; edema (58.5%), history of preeclampsia (14.1%), early-onset preeclampsia (28.8%) and severe preeclampsia (42.4%). Early onset increased the risk of severe preeclampsia with OR = 3.98 (95% CI: 2.10 - 7.55). 10.8% had complications, in the mother including HELLP syndrome, eclampsia, coagulation disorders and in the fetus including fetal distress, intrauterine growth retardation and premature birth. Maternal age ≥ 35 years old, history of miscarriage, BMI were associated with preeclampsia, with OR 3.36 (95% CI: 2.06 - 5.46); 1.67 (95% CI: 1.04 - 2.67); 6.66 (95% CI: 4.19 - 10.59), respectively. Conclusion: Severe preeclampsia accounted for a high rate, was associated with early onset, and complications were recorded in both mother and fetus. Maternal age, history of miscarriage and overweight were factors that increase the risk of preeclampsia.