1.One case of correlation between the human herpesvirus 7 DNA load and the hemo hagocytic syndrome.
Peng CAI ; Chun-rong TONG ; Jun-fang YANG ; Ying LIU ; Guo-lin XU ; Gian-feng ZHANG ; Cheng-liang ZHEN ; Gun-fang LI ; Zhi-ping TENG
Chinese Journal of Experimental and Clinical Virology 2011;25(2):123-125
OBJECTIVETo research the relationship between human herpesvirus 7 (HHV-7) viral Load and the etiopathogenisis of hemophagocytic syndrome, in order to provide evidence for the clinical diagnosis of hemophagocytic syndrome and anti-virus therapy.
METHODSPeripheral blood of patient with hemophagocytic syndrome during different treatment periods, extracted DNA, Syntheticed the primers of HHV-7, gene sequence of PCR amplified fragments detected, determined HHV-7 viral Load by Real-time fluorescent quantitative PCR and the ferritin concentration in peripheral blood detected by chemiluminescence.
RESULTThe sequence result indicated that PCR amplified fragment was a part of HHV-7 gene, the ferritin concentration viried with the load of HHV-7.
CONCLUSIONThe occurrence of hemophagocytic syndrome is connetted with the load of HHV-7.
Ferritins ; metabolism ; Herpesvirus 7, Human ; genetics ; isolation & purification ; physiology ; Humans ; Lymphohistiocytosis, Hemophagocytic ; metabolism ; virology ; Viral Load
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