Some investigators suggest that the pancreatic proteinase kallikrein plays an important role in the regulation of spermatozoal motility. Particularly, oral kallikrein therapy exerted a favorable effect on Sperm motility in oligozoospermia and asthenozoospermia. We have carried out a similar clinical investigation of the efficacy of kallikrein, taken orally 60 kU per day for 3-9 months, on the quantitative and qualitative motility of spermatozoa in normogonadotropic infertile men. with 15 idiopathic oligozoospermia and 18 idiopathic asthenozoospermia. Number of spermatozoa increased more than double number of basic levels (over 40 x 10(6)/ml) in the 5 patients (33%) and pregnancy occurred in the 3 patients (20%) out of the 15 patients with idiopathic oligozoospermia (less than 20 x 10(6)/ml) after the kallikrein therapy. In these responded 5 patients, the sperm concentration changed from 13.6 x 10(6)/ml to 54.0 x 10(6)/ml, Motility and viability of spermatozoa improved more than 30% in the 5 patients (28%) and pregnancy occurred in the 2patients (11%) out of the 18 patients with idiopathic asthenozoospermia (less than 20% of sperm motility) after the therapy. In these. improved 5 patients, the sperm motility changed from 9.0% to 45.0%. No remarkable side effect was detected.
Asthenozoospermia ; Humans ; Infertility, Male* ; Kallikreins ; Male ; Male* ; Oligospermia ; Pregnancy ; Research Personnel ; Semen* ; Sperm Motility ; Spermatozoa

Some investigators suggest that the pancreatic proteinase kallikrein plays an important role in the regulation of spermatozoal motility. Particularly, oral kallikrein therapy exerted a favorable effect on Sperm motility in oligozoospermia and asthenozoospermia. We have carried out a similar clinical investigation of the efficacy of kallikrein, taken orally 60 kU per day for 3-9 months, on the quantitative and qualitative motility of spermatozoa in normogonadotropic infertile men. with 15 idiopathic oligozoospermia and 18 idiopathic asthenozoospermia. Number of spermatozoa increased more than double number of basic levels (over 40 x 10(6)/ml) in the 5 patients (33%) and pregnancy occurred in the 3 patients (20%) out of the 15 patients with idiopathic oligozoospermia (less than 20 x 10(6)/ml) after the kallikrein therapy. In these responded 5 patients, the sperm concentration changed from 13.6 x 10(6)/ml to 54.0 x 10(6)/ml, Motility and viability of spermatozoa improved more than 30% in the 5 patients (28%) and pregnancy occurred in the 2patients (11%) out of the 18 patients with idiopathic asthenozoospermia (less than 20% of sperm motility) after the therapy. In these. improved 5 patients, the sperm motility changed from 9.0% to 45.0%. No remarkable side effect was detected.
Asthenozoospermia ; Humans ; Infertility, Male* ; Kallikreins ; Male ; Male* ; Oligospermia ; Pregnancy ; Research Personnel ; Semen* ; Sperm Motility ; Spermatozoa

No abstract available.
Leiomyoma*

OBJECTIVE: The study of 467 cases of amniocentesis have been done at the department of Genetics, Taegu Cheil Hospital from Oct. 1997 to May 1999 for the purpose of analysis of abnormal karyotype according to the indication and age distribution, METHODS: We collected amniotic fluid using 22G spinal needle and measured amniotic alphafetoprotein and acetylcholine esterase in supematant and performed cytogenetic analysis. RESULTS: Positive Down screeing(positive triple test) was the most common indication of amniocentesis (61.5%) and abnormal karyotypes were 24 cases(5.1%) in 467 cases. Among 24 abnormal cases, 10 cases(2.1%) of 21 trisomy were observed. Abnormal karyotypes were most common in the group of abnormal ultrasonogram finding and the gmup of maternal age between 31 to 35 years old, which consists of 25% and 7.7% respectively. CONCLUSION: More attention for the abnormal karyotype should be paid to the group of abnormal ultrasonogram finding and the group of maternal age between 31 to 35 years old as well as above 35 years old.
Abnormal Karyotype ; Acetylcholine ; Adult ; Age Distribution ; Amniocentesis ; Amniotic Fluid ; Cytogenetic Analysis* ; Cytogenetics* ; Daegu ; Female ; Genetics ; Humans ; Karyotype ; Maternal Age ; Needles ; Trisomy ; Ultrasonography

Bile* ; Choledochal Cyst* ; Humans ; Infant* ; Peritonitis*

No abstract available.
Animals ; Enalapril* ; Nicardipine* ; Nitroprusside* ; Rats* ; Skin*

Postoperative endophthalmitis is one of the devastating complications following cataract surgery. Ocular flora has been presumed to be a major source of infectious organisms in postoperative endophthalmitis. We compared the efficacies of various chemical preparation methods that decrease or eradicate ocular flora effectively before surgery. 355 eyes undergoing cataract surgery were randomly divided into 4 groups according to chemical preparation methods. 0.3% gentamicin eyedrop was used in group 1, 0.3% ciprofloxacin eyedrop in group 2, 0.3% gentamicin eyedrop and 5.0% povidone-iodine solution in group 3, and 0.3% ciprofloxacin eyedrop and 5.0% povidone-iodine solution were used in group 4 to prepare eye before surgery. Cultures of eyelid-conjunctival swab and aqueous humor were performed just before operation and at the time of wound closure, respectively, and then compared among 4 groups. The culturepositive rate was the lowest in group 4 and increased in group 3, group 2, and group 1 in a order. The culture-positive rate from the eyelid-conjunctiva in group 2 was significantly lower than that in group 1(p<0.05). The culture positive rates in the groups(group 3, 4) using the combination of antibiotics eyedrop and povidone-iodine solution for chemical preparation were significantly lower than those in the groups(group 1, 2) using antibiotics eyedrop only(p<0.05). The culture results of aqueous humor showed similar pattern as those from the eyelid-conjunctival swab. This study suggests that combined use of 0.3% ciprofloxacin eyedrop and 5.0% povidone-iodine solution is an effective and recommendable preoperative chemical preparation.
Anti-Bacterial Agents ; Aqueous Humor ; Cataract* ; Ciprofloxacin ; Endophthalmitis ; Gentamicins ; Povidone-Iodine ; Wounds and Injuries

No abstract available.
Axilla* ; Female* ; Humans ; Neck*

Thirty three patients with congenital agenesis of the vas deferens were investigated in Seoul National University Hospital for the past 10 years. These patients correspond to 2.4% of 1,398 infertile males and 14.8% of 223 azoospermic patients due to epididymal obstruction. These anomalies were confirmed by surgical explorations, They were consisted of 24 patients with bilateral agenesis of the vas deferens and 9 patients with unilateral agenesis(5 in right side, 4 in left side). Type 2 anomaly, vas agenesis without defects of epididymis, was found in 25(44%) of a total of 57 anomalies of the vas deferens. Type 1 anomaly, vas agenesis with defects on body or tail of epididymis, was found in 21(37%), and type 3 in which the head of epididymis and distal vas are identified but body and tail of epididymis and proximal vas are absent, was found in 11(19%). The histological examination of the testis showed normal spermatogenesis in the most of the patients, The seminal volume was reduced in 24 patients, and normal in 9 patients. The seminal fructose was reduced in 13 patients. It is suggested that vas agenesis would be associated with the absence of seminal vesicle in patients with reduced seminal volume and reduced seminal fructose level. In seven patients with unilateral agenesis of the vas deferens, the obstructive lesions of epididymal tails of contralateral side were corrected by epididymovasostomy under surgical microscope. The results were successful in 2 patients. In three patients with bilateral agenesis of the vas deferens of type 3, epididymovasostomy could be performed. Successful results were obtained in 2 patients. In conclusion, the results of this clinical investigation emphasize the importance of careful scrotal examination in the diagnosis of an infertile males and in the preparative examination of vasectomy operation.
Diagnosis ; Epididymis ; Fructose ; Head ; Humans ; Male ; Seminal Vesicles ; Seoul ; Spermatogenesis ; Testis ; Vas Deferens* ; Vasectomy

We report a case of Hunter's syndrome in an 8-year-old boy, who presented with ivory-white colored papules and ridges on the left chest area, which were regarded as pathognomonic cutaneous markers for Hunter's syndrome. He also showed growth retardation, dear corneas, hepatosplenomegaly and fair intellect. The histopathological findings of papular lesions revealed loosely arranged collagen fibers with massive mutinous material which stained positively with alcian blue at both pH 2.0 and 0.5. On quantitation of glycosaminoglycans by hexuronic add assay in 24-hour urine, excessive excretion of creatinine was noted. To the best of our knowledge, this is the first case in Korea.
Alcian Blue ; Child ; Collagen ; Cornea ; Creatinine ; Glycosaminoglycans ; Humans ; Hydrogen-Ion Concentration ; Korea ; Male ; Mucopolysaccharidosis II* ; Thorax