1.An animal model of extrahepatic portal hypertension.
Hong Gi LEE ; Sung Eun JUNG ; Kwi Won PARK
Journal of the Korean Surgical Society 1992;42(1):7-14
No abstract available.
Animals*
;
Hypertension, Portal*
;
Models, Animal*
2.Histochemical and ultrastructural changes of cyclosporin A and prednisolone on proximal tubules and glomeruli in rabbit kidney.
Korean Journal of Urology 1991;32(4):519-529
This experiment was designed to investigate the histochemical and ultrastructural changes of the proximal tubules and glomeruli of rabbits treated with cyclosporin A (CsA) or cyclosporin A and concomitant administration of prednisolone (PD). Rabbits were given with CsA for 1 week (CsAlW) and for 2 weeks (CsA2W) and CsA plus PD for 1 week (CsA +PDIW) and for 2 weeks (CsA+PD2W). The dose of CsA was 5mg/kg/day i.v. and PD was 1 mg/kg/day i.m. At 1 week and 2 weeks after the treatments, the following items were studied of alkaline phosphatase (ALPase). peroxidase, 5'-nucleotidase (SNU) with the ultrastructural enzymatic changes and electron microscopic changes. CsAlW, CsA2W and CsA +PD2W groups showed a decrease of ALPase activity and CsA+PD2W and CsA2W groups showed weakly increased peroxidase activity CsA2W and CsA+PD2W showed a decrease of 5NU activity. Ultrastructural changes of CsAlW CsA2W and CsA+PD2W groups revealed swollen and disrupted mitochondria, loss of brush border in the proximal tubules and thickening of basement membranes, edematous podocytes and fusion of root processes of podocytes in the glomeruli showing the early stage of nephrotoxicity. The concomitant treatment of PD with CsA eased the nephrotoxicity of CsA within 1 week after the treatment.
5'-Nucleotidase
;
Alkaline Phosphatase
;
Basement Membrane
;
Cyclosporine*
;
Kidney*
;
Microvilli
;
Mitochondria
;
Peroxidase
;
Podocytes
;
Prednisolone*
;
Rabbits
3.A Case of Embryonal Rhabdomyosarcoma of the External Female Genitalia.
Sung Koan CHOI ; Gi Young SEONG ; Do Won KIM ; Sang Lip CHUNG
Korean Journal of Dermatology 1988;26(6):928-933
We report a case of embryonal rhabdomyosarcoma with palpable right inguinal lymph node in a 6-year-old girl which developed rapidly on the right labia minora over a period of 2 montha. Histopathological study showed characteristic findings of spindle shaped rhabdomyoblast with hyperchromatic nuclei and cytoplasmicprocesses. After a preoperative chemotherapy with vincristine, actinomycin D, and cytoxan, the size of the mass was reduced, and lymph nodes were not palpable. And then, simple vulvectomy. postoperhtive cheirnatherapy and radiotherapy were done.
Child
;
Cyclophosphamide
;
Dactinomycin
;
Drug Therapy
;
Female
;
Female*
;
Genitalia, Female*
;
Humans
;
Lymph Nodes
;
Radiotherapy
;
Rhabdomyosarcoma, Embryonal*
;
Vincristine
4.STA-MCA Anastomosis: 9 Cases.
Myung Soo AHN ; Gi Won SUNG ; Chang Rak CHOI
Journal of Korean Neurosurgical Society 1983;12(4):657-665
Since 1967 the STA-MCA anastomosis has been popular procedure in neurosurgical operation. The meurosurgical teams at St. Paul's Hospital, Catholic Medical College, recently operated on 8 patients employing 9 times of this technique. The patients were diagnosed as four patients with complete stroke, one with traumatic middle cerebral stenosis, two with moyamoya disease, and one with huge aneurysm at intracavernous portion of ICA. The results were very encouraging of the 8 patients, 7 had favorably improved clinically, and proved by follow-up cerebral angiographies, CT Scanning, EEG or MEP recordings. The remaining one patient had intracerebral and intracerebellar hematoma, two months later after discharge, thus the result was poor. The authors would like to share with you their experiences employing the STA-MCA anastomosis technique, indications the results and the prognosis.
Aneurysm
;
Cerebral Angiography
;
Constriction, Pathologic
;
Electroencephalography
;
Follow-Up Studies
;
Hematoma
;
Humans
;
Moyamoya Disease
;
Prognosis
;
Stroke
;
Tomography, X-Ray Computed
5.Effect of Cisapride on ATP-sensitive K Channel of Ventricular Cell.
Sung Gi MOON ; Byeong Hyun IN ; Won Ho KIM ; Jae Ki KO
Korean Circulation Journal 1998;28(1):76-81
BACKGROUND: It has been generally accepted that Cisapride (Prepulsid?or propulsid?), a widely used gastrointestinal prokinetic agent, is associated with Torsades de Points, a life-threatening arrhythmia. Recently, cisapride-induced APD (action potential duration)-prolongation was inhibited by glibenclamide, a KATP channel blocker. But the direct effect of cisapride on K(ATP) channels has not been studied until now. Therefore, we investigated cisapride's effects on KATP channels of isolated rat ventricular myocytes. METHODS: After the isolation of rat ventricular myocytes, we analysed the single channel current with patch pipettes. The method of analysis was the student t-test. RESULTS: 1) Cisapride (10(-6) M- 10(-4) M) inhibited KATP channel opening without changing channel conductance Ki was about 20micronM, and Hill coefficient was 0.75. 2) Cisapride inhibited pinacidil-induced KATP channel opening in the cell attached mode. CONCLUSIONS: These results suggest that cisapride-induced APD prolongation and arrythmic effects may be partly related to KATP channel inhibition.
Animals
;
Arrhythmias, Cardiac
;
Cisapride*
;
Glyburide
;
Humans
;
KATP Channels
;
Muscle Cells
;
Rats
6.A Case of Congenital Generalized Linear Porokeratosis.
Ho Joon KIM ; Gi Young SUNG ; Do Won KIM ; Jae Bok JUN
Korean Journal of Dermatology 1989;27(1):94-98
Linear porokeratosis is a rare variant of porokerstosis and usually occurs after childhood. We report herein a case of linesr porokeratosis in an 18-year-old female. The lesions had developed since birth and were found on the nearly whole body, including the face, neck, axilla, chest, abdomen, back, and upper and lower extremities. Palms and soles were also affected. Biopsy specirnens from the left forearm and right sole showed typical cornoid lamellae. We could not see any improvement with a course of oral etretinate for 6 weeks.
Abdomen
;
Acitretin
;
Adolescent
;
Axilla
;
Biopsy
;
Etretinate
;
Female
;
Forearm
;
Humans
;
Lower Extremity
;
Neck
;
Parturition
;
Porokeratosis*
;
Thorax
7.The Alignment and Deformity of the Upper Extremity in Hereditary Multiple Exostoses.
Young Woo CHUNG ; Gi Heon PARK ; Hyeong Won PARK ; Sung Taek JUNG
The Journal of the Korean Bone and Joint Tumor Society 2011;17(1):11-16
PURPOSE: This study was aimed to analyze the incidence and the anatomical distributions of HME (Hereditary Multiple Exostoses) on upper limbs and its related change in alignment of the upper limbs in HME patients. MATERIALS AND METHODS: Thirty eight patients who had been diagnosed HME between 2001 and 2009, were categorized into two groups; (1) group A (1-2 involvements); (2) group B (> or =3 involvements). We checked the carrying angle, VAS (Visual Analogue Scale), limitations in daily activities, cosmetic satisfaction according to the number of exostoses invasion. RESULTS: Among the 38 patients, 23 patients (43 cases) had exostoses in the upper limbs. The locations of exostoses in the upper limbs were proximal humerus in 33 cases (30%), distal ulna in 31 cases (28.2%), and distal radius in 24 cases (21.8%). The carrying angle of group A and B was 10.7degrees, 13.8degrees, VAS was 1.3, 3.5, and the limitations in daily activities was 7.3, 6.6 of 8 points. The cosmetic satisfactory cases were 13 and 10 cases, respectively. CONCLUSION: The deformity in upper limbs was observed in 65% of the HME patients. As the number of invasion increases, carrying angle and VAS were increased but limitations in daily activities and cosmetic satisfaction were decreased.
Congenital Abnormalities
;
Cosmetics
;
Exostoses
;
Exostoses, Multiple Hereditary
;
Humans
;
Humerus
;
Incidence
;
Lifting
;
Radius
;
Ulna
;
Upper Extremity
8.A Case of Desmoplastic Trichoepithelioma.
Young Doo KIM ; Gi Young SUNG ; Do Won KIM ; Jae Bok JUN
Korean Journal of Dermatology 1989;27(4):470-473
We report herein a case of desmoplastic trichoepithelioma in a 73-year-old female, who is the oldest among the patients of the disease reported in Korea. She had an asymptomatic, hard, annular lesion, measuring 0.6 x 0.7 cm with an elevated border and a depressed center on the left nasolsbial fold. Histopathological findings showed narrow strands of basaloid tumor cells, horn cysts and a desmoplastic stroma.
Aged
;
Animals
;
Female
;
Horns
;
Humans
;
Korea
9.Portal flow steal after liver transplantation.
Bohyun KIM ; Kyoung Won KIM ; Gi Won SONG ; Sung Gyu LEE
Clinical and Molecular Hepatology 2015;21(3):314-317
Portal flow steal occasionally persists even after the liver transplantation, which may reduce the portal flow and thus threaten the patients' outcome. Therefore, pre- and peri-operative detection of portal steal phenomenon requiring radiological or surgical interruption is essential for the liver transplantation candidates as well as for the recipients.
Adult
;
Hepatitis B, Chronic/complications
;
Humans
;
Liver Cirrhosis/etiology/*therapy
;
*Liver Transplantation
;
Male
;
Mesenteric Veins/*ultrasonography
10.Multiple endocrine neoplasm, type I.
Sung Won CHUN ; In Sung MOON ; Jun Gi KIM ; Woo Bae PARK ; Jung Soo CHUN ; Won Sang PARK ; Kyo Yong LEE ; Chang Suck KANG
Journal of the Korean Surgical Society 1991;40(5):684-690
No abstract available.