1.Trends in the Diagnosis of Osteoporosis in Patients with Distal Radius Fractures Based on a National Claims Database
Dae Geun KIM ; Gi Won SEO ; Hye Won NAM
Journal of Bone Metabolism 2019;26(4):247-252
BACKGROUND: A history of osteoporotic fractures is strongly associated with the subsequent osteoporotic fractures. To prevent subsequent fractures, the diagnosis and treatment of osteoporosis following osteoporotic fractures are very important. A distal radius fracture (DRF) is the second most common type of osteoporotic fracture in South Korea. We analyzed the rate of osteoporosis diagnosis within 6 months post-DRF.METHODS: We used data from the Korean Health Insurance Review and Assessment Service nationwide claims database from 2010 to 2016. International Classification of Diseases, 10th revision codes and procedures codes were used to identify patients aged over 50 years with newly diagnosed DRFs; the osteoporosis assessments of these patients were then analyzed. We used Cochran-Armitage trend test to examine trends in osteoporosis diagnosis.RESULTS: A search of database identified 77,209 DRFs in patient aged above 50 years of age from 2011 to 2016. Among these patients, only 19,305 (25.0%) underwent diagnostic examination for osteoporosis. The number of osteoporosis examinations increased slightly, but not significantly, every year (P=0.061).CONCLUSIONS: Clinicians who treat DRFs shoulder also evaluated patients for osteoporosis after DRFs.
Diagnosis
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Humans
;
Insurance, Health
;
International Classification of Diseases
;
Korea
;
Osteoporosis
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Osteoporotic Fractures
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Radius Fractures
;
Radius
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Shoulder
2.Successful Live Birth of Woman with Antiphospholipid Syndrome.
Ho Yeul LEE ; Jung Ho SEO ; Sang Won LEE ; Young Gi LEE ; Min Whan KOH ; Tae Hyung LEE
Yeungnam University Journal of Medicine 1996;13(1):141-145
The antiphospholipid antibodies are characterized by prolonged phospholipid-dependent coagulation test (known as APTT or Russel viper venom), thrombosis, thrombocytopenia, and fetal loss. The association of antiphospholipid antibodies with one or more of these characteristic clinical features has been termed the i antiphospholipid syndrome. We have experienced a case of successful live birth after treated a woman with heparin and aspirin who has experienced spontaneous abortion four times with antiphospholipid antibodies and present it with the review of literature.
Abortion, Spontaneous
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Antibodies, Antiphospholipid
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Antiphospholipid Syndrome*
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Aspirin
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Female
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Heparin
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Humans
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Live Birth*
;
Pregnancy
;
Thrombocytopenia
;
Thrombosis
3.Clinical analysis of cleft palate patients.
Yang Gi MIN ; Sun O CHANG ; Ha Won JUNG ; Ic Tae KIM ; Chae Seo RHEE ; Hong Ryul JIN
Korean Journal of Otolaryngology - Head and Neck Surgery 1992;35(2):321-327
No abstract available.
Cleft Palate*
;
Humans
4.A Case of Turner Syndrome Associated with Autoimmune Thyroiditis and Empty Sella
Hong Seung KIM ; Joo Won BYUN ; Do Sik YOON ; Byung Gi SEO ; Young Goo SHIN ; Choon Hee CHUNG
Journal of Korean Society of Endocrinology 1996;11(1):114-118
No abstract available.
Thyroiditis, Autoimmune
;
Turner Syndrome
5.Evolving trends in treatment patterns for hepatocellular carcinoma in Korea from 2008 to 2022: a nationwide population-based study
Ji Won HAN ; Won SOHN ; Gwang Hyeon CHOI ; Jeong Won JANG ; Gi Hyeon SEO ; Bo Hyun KIM ; Jong Young CHOI
Journal of Liver Cancer 2024;24(2):274-285
Background:
s/Aims: The treatment landscape for hepatocellular carcinoma (HCC) has significantly evolved over the past decade. We aimed to analyze trends in treatment patterns for HCC using a nationwide claims database from the Korean Health Insurance Review and Assessment Service.
Methods:
This retrospective population-based cohort study analyzed 171,002 newly diagnosed HCC patients between 2008 and 2022. Etiologies and treatment modalities were categorized based on the ICD-10 codes and insurance data.
Results:
The annual incidence decreased from 11,814 in 2008 to 10,443 in 2022. However, patients aged ≥70 increased noticeably, with those aged ≥80 rising from 3.8% in 2008 to 13.1% in 2022. From 2008 to 2022, the predominant cause of hepatitis B virus decreased from 68.9% to 59.7%, whereas nonalcoholic fatty liver disease increased from 8.9% to 15.8%. The initial treatment trends shifted: surgical resection and systemic therapy increased from 12.2% to 21.3% and from 0.2% to 9.6%, whereas transarterial therapy decreased from 49.9% to 36.6%. Best supportive care decreased from 31.7% to 21.3%. In the subgroup analysis, laparoscopic resection rate increased from 10.6% to 60.6% among the surgical resections. Sorafenib initially accounted for 100%, lenvatinib peaked at 36.5% in 2021, and atezolizumab-bevacizumab became the most widely used (63.1%) by 2022 among the systemic therapies.
Conclusions
This study demonstrates the temporal changes in the treatment patterns of Korean HCC patients. Surgical resection, particularly laparoscopic liver resection, and systemic therapy has increased significantly. These changes may have been influenced by reimbursement policies and advances in clinical research.
6.Change in Medication of Osteoporosis in a University Hospital after Women's Health Initiative (WHI) Clinical Trial.
Tae Hoon KIM ; Gi Won SEO ; Young Sik KIM ; Sung SUNWOO
Journal of the Korean Academy of Family Medicine 2007;28(11):824-829
BACKGROUND: Recent evidence had shown from randomized trials published in July 2002 that demonstrated adverse cardiovascular disease events and other risks with hormone therapy in the form of oral estrogen combined with progestin caused limitation of its use. The purpose of this study was to describe change in medication of osteoporosis at an university hospital after the WHI clinical trial. METHODS: The study subjects were 644 and 656 women who underwent bone mass densiNometry (BMD) at an university hospital outpatient clinic in January 2002 and January 2003, respectively, with had no underlying disease for secondary osteoporosis. This study regarded January 2002 as before and Jan 2003 as after the publication of the WHI clinical trial. We analyzed change of Hormone replacement therapy (HRT), bisphosphonate, selective estrogen receptor modulator (SERM), tibolone, etc. RESULTS: More than one drug was prescribed for 425 (66%, before WHI) and 436 (66.5%, after WHI) patients among the two groups of study subjects, respectively. HRT was prescribed for 213 (33.07%) and 96 (14.63%) patients, respectively. The usage of the drugs decreased considerably after the publication of WHI clinical trial. This result was mainly due to the decline of combined estrogen/progesterone hormone therapy. The increase of bisphosphonate, SERM, calcium and vitamin D prescription was statistically significant. However, prescription for tibolone (livial) did not change. CONCLUSION: Combined estrogen/progesrerone therapy was considerably decreased after the publication of the Women's Health Initiative (WHI) clinical trial in accordance with the conclusion of the trial.
Calcium
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Cardiovascular Diseases
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Estrogens
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Female
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Hormone Replacement Therapy
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Humans
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Osteoporosis*
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Osteoporosis, Postmenopausal
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Outpatient Clinics, Hospital
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Prescriptions
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Publications
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Selective Estrogen Receptor Modulators
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Vitamin D
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Women's Health*
7.Can Motor Evoked Potentials Be an Objective Parameter to Assess Extremity Function at the Acute or Subacute Stroke Stage?.
Gi Wook KIM ; Yu Hui WON ; Sung Hee PARK ; Jeong Hwan SEO ; Myoung Hwan KO
Annals of Rehabilitation Medicine 2015;39(2):253-261
OBJECTIVE: To investigate whether motor evoked potential (MEP) amplitude ratio measurements are sufficiently objective to assess functional activities of the extremities. We also delineated the distribution between the presence or absence of MEPs and the Medical Research Council (MRC) scale for muscle strength of the extremities. METHODS: We enrolled 183 patients with first-ever unilateral hemiplegia after stroke. The MEP parameters were amplitude ratio (amplitude of affected side/amplitude of unaffected side) recorded at the first dorsal interosseous (FDI) and tibialis anterior (TA) muscles. We performed frequency analyses using the MRC scale for muscle strength and the presence or absence of evoked MEPs. Change on the MRC scale, hand function tests (HFTs), and the Modified Barthel Index (MBI) subscore were compared between the evoked MEP and absent MEP groups using the independent t-test. Receiver operating characteristic curves were used to determine the optimal cutoff scores for the MEP amplitude ratio using the HFT results and MBI subscores. Correlations between the MEP amplitude ratio and the MRC scale, HFTs, and MBI subscore were analyzed. RESULTS: About 10% of patients with MRC scale grades 0-2 showed evoked MEPs at the FDI muscle, and 4% of patients with MRC scale grades 3-5 did not show MEPs. About 18% of patients with MRC scale grades 0-2 showed evoked MEPs at the TA muscle, and 4% of patients with MRC scale grades 3-5 did not show MEPs. MEP amplitude increased with increasing MRC scale grade. The evoked MEP group had more significant changes on the MRC scale, HFT, and the climbing stair score on the MBI than those in the group without MEPs. Larger MEP amplitude ratios were observed in patients who had more difficulty with the HFTs and ambulation. The MEP amplitude ratio was significantly correlated with the MRC scale, HFT, and MBI subscore. CONCLUSION: We conclude that the MEP amplitude ratio may be useful to predict functional status of the extremities in patients who suffered stroke.
Activities of Daily Living
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Evoked Potentials, Motor*
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Extremities*
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Hand
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Hemiplegia
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Humans
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Motor Skills
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Muscle Strength
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Muscles
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ROC Curve
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Stroke*
;
Walking
8.Adrenaogenital Syndrome with Congenital Adrenal Hyperplasia.
Kyeong Rae MOON ; Yeong Bong PARK ; Sang Gi KIM ; Jin Heon KIM ; Chang Soo RA ; Jae Hong SEO ; Ho Won HWANG
Journal of the Korean Pediatric Society 1985;28(1):78-84
No abstract available.
Adrenal Hyperplasia, Congenital*
9.Effects of Rhodiola Sachalinensis on Nitric Oxide Synthesis by Macrophages, Hepatocytes, and Vascular Smooth Muscle Cells.
Hwa Kyung LEE ; Min Kyo SHIN ; Hyun Ock BAE ; Won Gil SEO ; Gi Su OH ; Byoung Sun AHN ; Hun Taeg CHUNG
Korean Journal of Immunology 2000;22(4):229-234
No abstract available.
Hepatocytes*
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Macrophages*
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Muscle, Smooth, Vascular*
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Nitric Oxide*
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Rhodiola*
10.ROM(Reducing Opposed Multilobed) Flap Repair for the Treatment of Medium Sized Skin Lesion.
Jong Je CHO ; Yoon Gi HONG ; Sang Won SEO ; Choong Hyun CHANG
Journal of the Korean Society of Plastic and Reconstructive Surgeons 2006;33(6):748-752
PURPOSE: Circular skin lesions between 10 and 35 mm in diameter generate problems often. Direct closure of the lesion risks excessive wound tension or wound dehiscence. Skin grafts heal slowly and often remain unsightly. Traditional skin flaps have a limited role. We treated this circular medium-sized skin lesion(10 - 35 mm sized) by reducing opposed multilobed(ROM) flap. METHODS: ROM flap involves a series of semicircular lobes extending both cephalic and caudal from the defect. Direction of the semicircular multilobed flap is set parallel to relaxed skin tension line(RSTL) to minimize scar formation. First semicircle is drawn 60% in diameter of the defect. Second semicircles are drawn at the cephalic and caudal aspects of the original semicircles. These semicircles are 60% in diameter of the first semicircle. Additional semicircles are repeatedly drawn until the tension of skin flaps becomes free. ROM flap has a length-to-base ratio of 0.5 resulting in lower theoretical risk of end flap necrosis than a random pattern flap with a large ratio. The technique involves lobes most distant from the primary defect being transposed in turn closer to the defect. RESULTS: The ROM flap reduces skin tension concerns, lowers the risk of flap necrosis and allows for quicker and more aesthetic healing. Results were generally good and major complications, such as dehiscence, infection, or delayed healing, did not occur. CONCLUSION: ROM flap repair allows the plastic surgeon an additional option when faced with a circular medium-sized skin lesion.
Cicatrix
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Necrosis
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Skin*
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Transplants
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Wounds and Injuries