1.A Case of Transient Acrodermatitis Enteropathica in a Full-Term Breast-Fed Infant.
Jee Youn WON ; Gi Bong JUNG ; Young Min JEON ; Jee Bum LEE ; Eun Sup SONG
Korean Journal of Dermatology 1999;37(6):790-793
We herein report a case of transient acrodermatitis enteropathica in a 3-month-old, breast-fed, full-term infant. The patient was presented with a 2-month history of diarrhea and crusted erythema- tous patches on the periorificial area. Similar lesions were seen in his siblings. His serum zinc level and the zinc level in his mother's breast milk were markedly reduced. Diarrhea and skin lesions disappeared promptly with oral zinc supplementation and did not recur when zinc was discontinued after three weeks. Our case indicates that even full-term infants, who feed excl-usively on mothers milk, run a risk of developing zinc deficiency, if the concentration of zinc in the breast milk is very low.
Acrodermatitis*
;
Diarrhea
;
Humans
;
Infant*
;
Milk
;
Milk, Human
;
Mothers
;
Siblings
;
Skin
;
Zinc
2.Breast Parenchymal Change on Mammography Following Postmenopausal Hormone Replacement Therapy.
Kyung Sang LEE ; Hee Soo KIM ; Jong Yoon WON ; Pyoung JEON ; Sun Jung KIM ; Jae Beom NA ; Jae Whan WON ; Yong Gi MIN
Journal of the Korean Radiological Society 1994;31(5):983-988
PURPOSE: To determine the frequency and distribution of parenchymal changes on mammography before and after hormone replacement therapy. MATERIALS AND METHODS: Mammograms of 100 postmenopausal women who underwent hormone replacement therapy without breast disease were evaluated. Mammograms obtained annually after hormone replacement were analysed and compared with that of pretreatment. In addition, mammograms of control group and treatment group were compared. RESULTS: An increase in density of breast parenchyma was seen on the mammogram of 20 women(20%) receiving therapy. The mammograms from the control group showed no change. Mammographic changes were detected at first year in 13 women, 2nd year in 4 women, 3rd year in 2 women, and 4th year in 1 woman (average,19 months). CONCLUSION: We conclude that increase in mammographic density following postmenopausal hormone replacement therapy is not uncommon(20%).
Breast Diseases
;
Breast*
;
Estrogen Replacement Therapy*
;
Female
;
Hormone Replacement Therapy
;
Humans
;
Mammography*
3.The Role of Inducible Nitric Oxide Synthase in the Development of Nasal Hyper-responsiveness of the Rhinosinusitis Rat Model.
Jin Pyeong KIM ; Sea Yuong JEON ; Seong Ki AHN ; Won Hyo HWANG ; Byung Gi SUNG ; Eun Ah KIM
Korean Journal of Otolaryngology - Head and Neck Surgery 2003;46(1):35-41
BACKGROUND AND OBJECTIVES: Hyper-responsiveness to nonspecific stimuli is a characteristic finding of all allergic diseases. It is probably due to eosinophil infiltration, release of cytotoxic proteins, and epithelial damage in the airway mucosa. However, the whole mechanism has not been clearly established. We aimed to understand the role of inducible nitric oxide synthase (iNOS) expression in nasal hyper-responsiveness of rhinosinusitis. MATERIALS AND METHOD: 1) To develop a platelet activating factor (PAF)-induced rhinosinusitis rat model, 50 micro liter of 16 micro gram/ml PAF was applied into the nose of rats. At days 1, 3 and 5, the rats were killed. 2) To demonstrate the hyper-responsiveness to topically applied capsaicin, 30 micro liter of 10 micro M capsaicin was applied intranasally and the amount of microvascular leakage in the nasal mucosa was measured with Evans blue assay at days 1, 3 and 5 in the rhinosinusitis model and the control rats. 3) To examine the effect of iNOS, 75 mg/kg of aminoguanidine was pretreated systemically 1 hour before the application of capsaicin. 4) To localize the expression of iNOS, immunohistochemical staining was performed using the avidin-biotin-peroxidase method with an anti-iNOS antibody. RESULTS: Induction of rhinosinusitis by application of PAF was confirmed with histology. A significant infiltration of eosinophils and loss of the epithelium, varied according to the time interval, were observed. A significant enhancement of microvascular leakage was clearly demonstrated by topically applied capsaicin, which was completely blocked by aminoguanidine, the iNOS inhibitor in the PAF-induced rhinosinusitis. The expression of iNOS was localized in the inflammatory cells infiltrated in the mucosa. CONCLUSION: The expression of iNOS in the inflammatory cells as well as epithelial damage related to eosinophil infiltration may cause nasal hyper-responsiveness.
Animals
;
Capsaicin
;
Eosinophils
;
Epithelium
;
Evans Blue
;
Models, Animal*
;
Mucous Membrane
;
Nasal Mucosa
;
Nitric Oxide Synthase
;
Nitric Oxide Synthase Type II*
;
Nose
;
Platelet Activating Factor
;
Rats*
;
Sinusitis
4.Pulse pressure during the initial resuscitative period in patients with septic shock treated with a protocol-driven resuscitation bundle therapy
Sang-Hun LEE ; Youn-Jung KIM ; Gi Na YU ; Jae Cheon JEON ; Won Young KIM
The Korean Journal of Internal Medicine 2021;36(4):924-931
Background/Aims:
Maintaining a mean arterial pressure (MAP) ≥ 65 mmHg during septic shock should be based on individual circumstances, but specific target is poorly understood. We investigated associations between time-weighted average (TWA) hemodynamic parameters during the initial resuscitative period and 28-day mortality.
Methods:
Prospectively collected data were obtained from a septic shock patient registry, according to the Sepsis-3 definition, between 2016 and 2018. The TWA systolic blood pressure, diastolic blood pressure, MAP, shock index, and pulse pressure (PP) during the first 6 hours after shock recognition were compared. Multivariable regression analysis was performed to assess associations between these parameters and 28-day mortality.
Results:
Of 340 patients with septic shock, 92 died. Only the median TWA PP differed between the survivors and non-survivors (39.2 mmHg vs. 43.0 mmHg, p = 0.020), whereas the other indexes did not. When PP was divided into quartiles (< 34, 34 to 40, 40 to 48, and > 48 mmHg), the mortality rate was higher in the highest quartile (41.2%). Multivariable logistic analysis revealed that PP (odds ratio [OR], 1.28; 95% confidence interval [CI], 1.012 to 1.622; p = 0.039) and PP of > 48 mmHg (OR, 2.25; 95% CI, 1.272 to 3.981; p = 0.005) were independently associated with 28-day mortality.
Conclusions
PP was significantly associated with 28-day mortality in patients with septic shock and MAP maintained at > 65 mmHg during the first 6 hours. Further studies are warranted to optimize strategies for maintaining PP and MAP at > 65 mmHg during the early resuscitative period.
5.Complete response in hepatocellular carcinoma with lymph node metastasis by combination therapy of atezolizumab and bevacizumab: a case report
Sang Youn HWANG ; Sun Mi LEE ; Jeong Woo LIM ; Gi Jung JEON ; Hye Won LEE
Journal of Liver Cancer 2021;21(2):177-180
Sorafenib is the oldest first line systemic treatment in patients with advanced hepatocellularcarcinoma (HCC) and has been used exclusively for nearly 10 years. The superiority ofadministering a combination of atezolizumab plus bevacizumab (AteBeva) compared tosorafenib as first line systemic treatment for unresectable HCC was recently proven duringthe IMbrave150 Phase III randomized trial. While clinicians can expect improved responsesand treatment outcomes due to the good results of the IMbrave 150 trial, they must alsoconsider that atezolizumab can cause various immune-related adverse events (IrAEs). Basedon the above suggestions, we herein present a case of HCC with lymph node metastasiswho achieved complete remission following treatment with AteBeva and developed an IrAE(adrenal insufficiency). Further study of real-life data regarding combination therapy withAteBeva is needed to manage patients with advanced HCC.
6.Complete response in hepatocellular carcinoma with lymph node metastasis by combination therapy of atezolizumab and bevacizumab: a case report
Sang Youn HWANG ; Sun Mi LEE ; Jeong Woo LIM ; Gi Jung JEON ; Hye Won LEE
Journal of Liver Cancer 2021;21(2):177-180
Sorafenib is the oldest first line systemic treatment in patients with advanced hepatocellularcarcinoma (HCC) and has been used exclusively for nearly 10 years. The superiority ofadministering a combination of atezolizumab plus bevacizumab (AteBeva) compared tosorafenib as first line systemic treatment for unresectable HCC was recently proven duringthe IMbrave150 Phase III randomized trial. While clinicians can expect improved responsesand treatment outcomes due to the good results of the IMbrave 150 trial, they must alsoconsider that atezolizumab can cause various immune-related adverse events (IrAEs). Basedon the above suggestions, we herein present a case of HCC with lymph node metastasiswho achieved complete remission following treatment with AteBeva and developed an IrAE(adrenal insufficiency). Further study of real-life data regarding combination therapy withAteBeva is needed to manage patients with advanced HCC.
7.Pulse pressure during the initial resuscitative period in patients with septic shock treated with a protocol-driven resuscitation bundle therapy
Sang-Hun LEE ; Youn-Jung KIM ; Gi Na YU ; Jae Cheon JEON ; Won Young KIM
The Korean Journal of Internal Medicine 2021;36(4):924-931
Background/Aims:
Maintaining a mean arterial pressure (MAP) ≥ 65 mmHg during septic shock should be based on individual circumstances, but specific target is poorly understood. We investigated associations between time-weighted average (TWA) hemodynamic parameters during the initial resuscitative period and 28-day mortality.
Methods:
Prospectively collected data were obtained from a septic shock patient registry, according to the Sepsis-3 definition, between 2016 and 2018. The TWA systolic blood pressure, diastolic blood pressure, MAP, shock index, and pulse pressure (PP) during the first 6 hours after shock recognition were compared. Multivariable regression analysis was performed to assess associations between these parameters and 28-day mortality.
Results:
Of 340 patients with septic shock, 92 died. Only the median TWA PP differed between the survivors and non-survivors (39.2 mmHg vs. 43.0 mmHg, p = 0.020), whereas the other indexes did not. When PP was divided into quartiles (< 34, 34 to 40, 40 to 48, and > 48 mmHg), the mortality rate was higher in the highest quartile (41.2%). Multivariable logistic analysis revealed that PP (odds ratio [OR], 1.28; 95% confidence interval [CI], 1.012 to 1.622; p = 0.039) and PP of > 48 mmHg (OR, 2.25; 95% CI, 1.272 to 3.981; p = 0.005) were independently associated with 28-day mortality.
Conclusions
PP was significantly associated with 28-day mortality in patients with septic shock and MAP maintained at > 65 mmHg during the first 6 hours. Further studies are warranted to optimize strategies for maintaining PP and MAP at > 65 mmHg during the early resuscitative period.
8.Antibacterial effect of mouthwash containing CPC against dental caries caused bacteria
Won-Ho CHO ; Ja-Won CHO ; Hyun-Jun YOO ; Kyong-Hoon SHIN ; Gi-Hae SHIN ; Yeol-Mae JEON ; Jong-Cheon LEE
Journal of Korean Academy of Oral Health 2021;45(2):87-91
Objectives:
The purpose of this study was to evaluate and report the antibacterial efficacy in relation to oral disease-causing bacteria using a mouthwash containing 0.05% CPC in an in vitro test.
Methods:
The sterilization test and susceptibility assay of mouthwash containing 0.05% CPC were investigated against Streptococcus mutans, Streptococcus sobrinus, and Lactobacillus acidophilus;Streptococcus sanguinis as oral bacteria related to dental caries; Enterococcus faecalis as apical periodontitis-related bacteria; and Actinomyces israelii, Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum, Prevotella intermedia, Prevotella nigrescence, Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, and Filifactor alocis as periodontal disease-related bacteria.
Results:
In the sterilization test, most of the bacteria had more than 99.99% sterilizing power for all samples but compared to other bacteria, the sterilizing power of these samples was not successful for L. acidophilus and E. faecalis bacteria. When comparing the sterilization power between the samples, sample 3 (0.05% CPC+20% ethanol) was the strongest.
Conclusions
In the antimicrobial activity test, sample 3 inhibited growth at the lowest concentration overall.
9.Antibacterial effect of mouthwash containing CPC against dental caries caused bacteria
Won-Ho CHO ; Ja-Won CHO ; Hyun-Jun YOO ; Kyong-Hoon SHIN ; Gi-Hae SHIN ; Yeol-Mae JEON ; Jong-Cheon LEE
Journal of Korean Academy of Oral Health 2021;45(2):87-91
Objectives:
The purpose of this study was to evaluate and report the antibacterial efficacy in relation to oral disease-causing bacteria using a mouthwash containing 0.05% CPC in an in vitro test.
Methods:
The sterilization test and susceptibility assay of mouthwash containing 0.05% CPC were investigated against Streptococcus mutans, Streptococcus sobrinus, and Lactobacillus acidophilus;Streptococcus sanguinis as oral bacteria related to dental caries; Enterococcus faecalis as apical periodontitis-related bacteria; and Actinomyces israelii, Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum, Prevotella intermedia, Prevotella nigrescence, Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, and Filifactor alocis as periodontal disease-related bacteria.
Results:
In the sterilization test, most of the bacteria had more than 99.99% sterilizing power for all samples but compared to other bacteria, the sterilizing power of these samples was not successful for L. acidophilus and E. faecalis bacteria. When comparing the sterilization power between the samples, sample 3 (0.05% CPC+20% ethanol) was the strongest.
Conclusions
In the antimicrobial activity test, sample 3 inhibited growth at the lowest concentration overall.
10.Treatment of Partial Thickness Skin Defect with Cultured Allogenic Keratinocytes (Kaloderm.).
Sang Won SEO ; Choong Hyun CHANG ; Min Su CHO ; Yoon Gi HONG ; Sae Wha JEON
Journal of the Korean Society of Traumatology 2007;20(1):1-5
PURPOSE: Grafting with autograft skin remains the most effective method for treating skin defects. When insufficient donor sites are present or patients are afraid of the operation, a skin graft is impossible. Cultured allogenic keratinocytes speed wound healing by providing cover and by producing growth factors and extracellular matrix protein. We report an application of cultured allogenic keratinocytes (Kaloderm., Tegoscience, Seoul, Korea) in the treatment of an acute partial thickness skin defect. METHODS: From March 2005 to January 2006, 20 patients with a partial thickness skin defect were treated with cultured allogenic keratinocytes. The wound was covered with a sheet of cultured allogenic keratinocytes and ointment with Bactigras. gauze. The wound was inspected every two or three days. We regarded completion of epithelialization as wound healing. RESULTS: The mean period between time of injury and time of Kaloderm. application was 7.5 days. The time taken from application of Kaloderm. to complete closure of the wounds was 7.2 days. CONCLUSION: In view of the favorable outcome, cultured allogenic keratinocytes are safe and effective biologic dressing materials for use in the treatment of open wounds.
Autografts
;
Biological Dressings
;
Extracellular Matrix
;
Humans
;
Intercellular Signaling Peptides and Proteins
;
Keratinocytes*
;
Seoul
;
Skin*
;
Tissue Donors
;
Transplants
;
Wound Healing
;
Wounds and Injuries