1.Ginsenoside Rg1 ameliorates blood-brain barrier disruption and traumatic brain injury
Kefeng ZHAI ; Hong DUAN ; Wei WANG ; Siyu ZHAO ; Ghulam Jilany KHAN ; Mengting WANG ; Yuhan ZHANG ; Kiran THAKUR ; Xuemei FANG ; Chao WU ; Jianbo XIAO ; Zhaojun WEI
Acta Pharmaceutica Sinica B 2021;11(11):3493-3507
During the traumatic brain injury (TBI), improved expression of circulatory miR-21 serves as a diagnostic feature. Low levels of exosome-miR-21 in the brain can effectively improve neuroinflammation and blood-brain barrier (BBB) permeability, reduce nerve apoptosis, restore neural function and ameliorate TBI. We evaluated the role of macrophage derived exosomes-miR-21 (M-Exos-miR-21) in disrupting BBB, deteriorating TBI, and Rg1 interventions. IL-1
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