1.Prescriptions and indications of hormone replacement therapy.
Korean Journal of Medicine 2005;68(4):469-472
No abstract available.
Hormone Replacement Therapy*
;
Prescriptions*
2.Effects of dexamethasone on proliferation, collagen synthesis and alkaline phosphatase activity of normal human bone marrow stromal cells.
Journal of Korean Society of Endocrinology 1993;8(1):59-65
No abstract available.
Alkaline Phosphatase*
;
Bone Marrow*
;
Collagen*
;
Dexamethasone*
;
Humans*
;
Mesenchymal Stromal Cells*
3.Autoantigenic Role of Variant Thyroperoxidase
Young Kee SHONG ; Dae Hyuk MOON ; Ghi Su KIM
Journal of Korean Society of Endocrinology 1996;11(1):61-67
Background: Thyroperoxidase(TPO) is one of the most important autoantigens in autoimmune thyroid disorders and autoantibody to TPO is found in almost every patients with various autoimmune thyroid diseases. Human TPO was already cloned and the completed nucleotide sequences are well known. In human thyroid tissues, several variants mRNA's of TPO are found in addition to the wild type. Especially the variants lacking exon 10(TPOΔexon10) and exon 16(TPOΔ exon16) are found in very large amount in both normal and Graves thyroid tissues. The significance of these variants TPO mRNAs are largely unknown. The authors tried to investigate the autoantigenic role of these variant TPO. Methods : To produce variant TPO cDNAs, oligonucleotide directed mutagenesis was performed using cDNA for wild type human TPO as template. The produced variants cDNAs were transfected into Cos-7 cells and variants TPO proteins were tested against patients sera showing high titers of anti-TPO antibody. Results: Seven of 12 Graves sera reacted with TPOΔexon 10 and 8 Graves sera with TPOΔ exonl6. Eight of 15 Hashimoto sera reacted TPOΔexon16 and 9 with TPOΔexon16. The reactivity with variants TPO was not related to clinical findings. Conclusion: These two variant TPOs, that is TPOexon10 and TPOΔexon16, could act as an autoantigen if they were translated in vivo, and could play a role in autoimmune thyroid disease. Their exact role in the pathogenesis of autoimmune thyroid disorders are to be clarified.
Animals
;
Autoantigens
;
Base Sequence
;
Clone Cells
;
COS Cells
;
DNA, Complementary
;
Exons
;
Humans
;
Mutagenesis, Site-Directed
;
RNA, Messenger
;
Thyroid Diseases
;
Thyroid Gland
4.Effects of Interleukin-6 on mRNA Expression of Alkaline Phosphatase, Osteopontin, Decorin and a1(1)-collagen in Human Bone Marrow Stromal Cells
Chul Hee KIM ; Dong Kwan KIM ; Seung Il PARK ; Kwang Hyun SOHN ; Ghi Su KIM
Journal of Korean Society of Endocrinology 1996;11(2):156-162
Background: Inter1eukin-6(IL-6) is known to be produced by osteoblastic cells and to have impartant role in regulation of bone remodelling, Most previous studies indicated that IL-6 bas a major role in stimulating osteoclastic resorption by increasing recruitment and proliferation of preosteoclasts. But its autocrine effect on osteoblastic cells has not been well established yet. Therefore, we studied the effects of IL-6 on messenger RNA (mRNA) expression of proteins that are characteristic of osteoblastic cells in human bone marrow stromal (osteoprogenitor) cells (hRMSC). Methods: The expression of mRNAs for alkaline phosphatase, al(1)-collagen, osteopontin and decorin were studied by northern blot analysis after 3 7 days' treatrnent with IL-6 in the concenttation range of 101,000 U/ml. Results: The mRNA levels for any of the osteoblastic proteins studied did not change significantly by IL-6 treatment up to the concentration of 1,000 U/ml. Conclusion: These results suggest that IL-6 does not have a significant role in differentiatian or activities of human bone rnarrow stromal.
Alkaline Phosphatase
;
Blotting, Northern
;
Bone Marrow
;
Decorin
;
Humans
;
Interleukin-6
;
Mesenchymal Stromal Cells
;
Osteoblasts
;
Osteoclasts
;
Osteopontin
;
RNA, Messenger
5.Autonomously functioning thyroid nodules.
Young Kee SHONG ; Ki Up LEE ; Ghi Su KIM ; Munho LEE
Journal of Korean Society of Endocrinology 1992;7(2):121-126
No abstract available.
Thyroid Gland*
;
Thyroid Nodule*
7.A case of isolated ACTH deficiency.
Seung Won CHOI ; Ki Up LEE ; Dong Wan SEO ; Ghi Su KIM ; Munho LEE
Journal of Korean Society of Endocrinology 1992;7(4):397-401
No abstract available.
Adrenocorticotropic Hormone*
8.Aging and Hormone: Estrogen, Parathyroid hormone and Bone Metabolism.
Korean Journal of Medicine 1998;55(4):523-522
No abstract available.
Aging*
;
Estrogens*
;
Metabolism*
;
Parathyroid Hormone*
9.Aging and Hormone: Estrogen, Parathyroid hormone and Bone Metabolism.
Korean Journal of Medicine 1998;55(4):523-522
No abstract available.
Aging*
;
Estrogens*
;
Metabolism*
;
Parathyroid Hormone*
10.A case of pituitary stone eith hypopituitarism combined with primary hypothyroidism.
Hyoung Eun IM ; Chi Yuel KIM ; Young Bum KIM ; Young Suk CHUNG ; Min Hwa CHUNG ; Ghi Su KIM ; Suk CHO
Journal of Korean Society of Endocrinology 1991;6(3):266-270
No abstract available.
Hypopituitarism*
;
Hypothyroidism*