1. Acute kidney injury in leptospirosis: Overview and perspectives
Geraldo DA SILVA JUNIOR ; José PINTO ; Geysa FARIAS ; Renan ALENCAR ; Nattachai SRISAWAT ; Nattachai SRISAWAT ; Gabriela GALDINO ; Ênio MACEDO ; Roberto PIRES NETO ; Elizabeth DE FRANCESCO DAHER ; Elvino BARROS
Asian Pacific Journal of Tropical Medicine 2018;11(10):549-554
Leptospirosis is a bacterial disease disseminated through the centuries in the whole world which causes symptoms that go from self-limited diseases to hemorrhagic manifestations and organ failure, including acute kidney injury (AKI), composing the severe disease known as the Weil's syndrome. Mortality rates varies according to the clinical presentation and usually increases when kidney injury is present, and is even higher in the setting of pulmonary hemorrhage. There are recent advances in the search for novel biomarkers of renal involvement and early detection of AKI in leptospirosis, as well as in its pathophysiology. We review in this article the clinical aspects of leptospirosis-associated AKI and the perspectives for future research.
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