No abstract available.

We report a case of Mondor's disease, or superficial thrombophlebitis of the chest wall, which occured in a 35-year-old female after a mild blunt trauma of the right chest wall. She had 0.3 × 25 cm, firm, tender, bifurcated cord-like lesions on the right chest and upper abdomen for two weeks. The histopathologic findings corresponded to the “thrombus organization” stage of Mondor's disease, characterized by numerous small areas of recanalization with marked surrounding fibrosis. The patient was treated with non-steroidal antiinflammatory drugs and warm compresses. Within 7 weeks, the cord-like lesions virtually disappeared.
Abdomen ; Adult ; Female ; Fibrosis ; Humans ; Thoracic Wall ; Thorax ; Thrombophlebitis

We report a case of eosinophilic pustular folliculitis in a 18-year-old woman who had numerous mild pruritic erythematous plaques with follicular papules and pustules covering almost her whole body. Histopathologically intrafollicular, perifollicular and perivascular eosinophilic infiltrates were present with mild spongiosis. The blocd eosinophil count was 9%. The patient responded well to systemic administration of corticosteroid and dapsoni.
Adolescent ; Eosinophils* ; Female ; Folliculitis* ; Humans

PURPOSE: Newborn infants with diarrhea, metabolic acidosis and dehydration may develop methemoglobinemia without exposure to oxidizing agents. This study was undertaken to investigate clinical features in the development of methemoglobinemia in newborn infants with diarrhea. METHOD: This study involved 16 newborn infants with diarrhea who were admitted to NICU at Dong San Medical Center between January 1995 and June 1996. We investigated the age of onset of methemoglobinemia, sex ratio, level of methemoglobin in the blood, feeding methods, clinical manifestations, arterial blood gas findings, the results of culture findings and the response to therapy. RESULT: 1) The age of onset was beyond the second week of life in most cases, no sex predilection was noted and formula feeding was used in all cases. 2) Methemoglobin level in the blood was 10.1-20.0% in 7 cases, 20.1-30.0% in 6 cases, 30.1-40.0% in 2 cases and above 40.1% in one case. 3) Clinical rnanifestations on admission: moderate to severe dehydration developed in all patients with diarrhea along with respiratory distress in 13 cases, cyanosis in 6 cases, fever was noted in 5 cases, vomiting in 5 cases, while 2 cases presented with abdominal distention. Combined diseases included metabolic acidosis in most cases (93.8%), hypokalemia in 6, failure to thrive in 3, chronic diarrhea in 2, hyponatremia in 2, necrotizing enterocolitis in 1 and hepatitis was found in one case. 4) In all cases, there were no pathogenic organisms found in either blood or urine cultures along with similar negative findings in stool cultures, and Rotazyme test results using ELISA method were negative. 5) Rehydration and correction of acidosis with sodium bicarbonate was accomplished in all patients and 11 cases with greater than 15% methemoglobin were treated with methylene blue, 2mg/kg as a 1% solution in normal saline. Response to methylene blue was indicated in 1 to 2 hours in all cases although there was a reoccurrence of methemoglobinemia after an initial response in 2 cases, they both responded favorably with retreatment with methylene blue. CONCLUSION: In all newborn infant with diarrhea, dehydration and metabolic acidosis, screening tests for early diagnosis of methemoglobinemia should be considered with prompt fluid replacement therapy.
Acidosis ; Age of Onset ; Cyanosis ; Dehydration ; Diarrhea* ; Early Diagnosis ; Enterocolitis, Necrotizing ; Enzyme-Linked Immunosorbent Assay ; Failure to Thrive ; Feeding Methods ; Fever ; Fluid Therapy ; Hepatitis ; Humans ; Hypokalemia ; Hyponatremia ; Infant* ; Infant, Newborn* ; Mass Screening ; Methemoglobin ; Methemoglobinemia* ; Methylene Blue ; Oxidants ; Retreatment ; Sex Ratio ; Sodium Bicarbonate ; Vomiting

BACKGROUND: Squamous cell caircinoma(SCC) often shows acantholysis as a result of degenerative changes of neoplastic cells. Regurding the acantholytic changes of SCC most textbooks and literature describe the acantholysis-associated tubular or alveolar structures, which are diagnostic features of adenoid SCC. But the acantholytic changes of SCC are not always assaciated with tubular or alveolar structres. The general and detailed histologic features of acantholysis of SCC have not been reported. OBJECTIVE: We analyzed the histologic features of acantholysis of SCC . MEHTODS: Twenty six biopsy specimens from 26 patients with SCC were studied for the distributions and sites of acantholysis such as lefts and tubular or alveolar structurs on routine histologic staining. RESULTS: All 26 biopsy specimens showed acantholysis in their tumors ocal acantholysis was found in 12 cases, and diffuse, widesprcad acantholysis was found in 14 cascs. The foci of acantholysis were in the surface epidermis in 9 cases, in the follicular wall in 5 cases, and in both the surface epidermis and the follicuar wall in 12 cases. The types of acantholytic cells were either dyskeratotic cells or non-dyskeratotic squamous cells. Tuthular or alveolar structures were found in 5 cases. Clefts were found in 12 cases, one in the subcomealarea, the other 11 were within tumor mases, and one of them showed Darier-like feature with papillary projections of neoplastic cells into thc lumens. CONCLUSION: The acantholytic hanges of the SCC are more comrr on y found than expected. The acantholytic changes involve not only dyskeratotic cells but also non-dysL eratotic cells and often show glandular structures and clefts.
Acantholysis* ; Adenoids ; Biopsy ; Carcinoma, Squamous Cell* ; Dronabinol ; Epidermis ; Humans

Wiskott-Aldrich Syndrome is an X-linked disorder characterized by recurrent infection, thrombocypenia and eczema. Various defects in cell-mediated immunity and deficient antibody reponse to carbohydrate antigens have been described. We experienced a case of Wiskott-Aldrich Syndrome of 28 months old male patient. He has been suffered from multiple petechiae with bleeding, recurrent pyogenic infections and generalized eczema since 3 months of age. Immunological abnormalities are as follows: 1) Serum IgM was gradually decreased, while IgA and IgE were increased. 2) Antibody response against polysaccharide antigen (PRP) was not observed after 3 times of PRPT immunization. 3) CD4/CD8 ratio was reversed (0.6). 4) Proliferative response of mononuclear cells was significantly reduced, and CMI skin test also showed negative results. A brief review of literature was made.
Antibody Formation ; Child, Preschool ; Eczema ; Hemorrhage ; Humans ; Immunity, Cellular ; Immunization ; Immunoglobulin A ; Immunoglobulin E ; Immunoglobulin M ; Male ; Purpura ; Skin Tests ; Wiskott-Aldrich Syndrome*

Seborrheic keratosis is a benign epidermal lesion, that commony develops in the aged. It exhibits a remarkable spectrum of histologic variations. We evaluated one hundred and one cases of seborrheic keratoses according to the histologie typing by Lever and Schaurnburg-Lever. The most common histologic type was the acanthotic type(50.5%), and the next. most common one was hyperkeratotic type(33.7%). The rest of the caces were relatively uncommon, irritated type(6.9%), mixed type(4.9%), clonal type(3.9%), adenoidal type(2.0%), and melanoacanthoma(1.0%). In 2 cases, mixed type was found in a lesion.
Adenoids ; Keratosis, Seborrheic*

Chondrosarocoma is a malignant, relatively slow-growing cartilaginous tumor that generally has a long natural history. From Feb. 1986 to Jan. 1993, 29 cases of chondrosarcoma were registered in the Department of Orthopedic Suergery of Korea Cancer Center Hospital. We reviewed 23 cases of chondrosarcoma which were treated surgically, aimed at curative procedure. Fourteen patients were male and 9 female. The average age at the time of diagnosis was 31.9(17-59) years. The pelvis was the most frequent site(7 patients) followed by femur(6), scapula(4), tibia(2), and each one case of spine, rib, humerus, and finger. The Enneking s surgical stage was II B (18 cases), II A (1), I B (3) or I A (1). The histological grades were as follows : 4 cases of grade 1; 3 grade 2 and 16 grade 3. Local resection with or without reconstruction were done for 20 cases and amputation or disarticulation 3. Chemotherapy was done in four cases and was not effective. The average follow-up period was 34.2(9-81) months. As complications, local recurrence occurred in 4(17.3%) cases, infection 2(8.7%), fracture 1(4.3%), lymphedema 1 and rediation necrosis of soft tissue 1, Distant metastasis occurred in 7(30.0%) cases: 6 cases to lung and 1 to brain. At final follow up 15 cases were continuous disease free, 3 alive with disease, 4 died of disease and 1 no evidence of disease. The Kaplan-Meier's estimated 5-year actuarial survival rate of total 23 cases was 66. 9%. Seven cases with histopathologic grade less than 2 showed 100% of 5 year actuarial survival rate, even one case is alive with disease at final follow up of 62 months. Fifteen cases of surgical stage II B with histopathologic grade 3 had 55.4% of 5 year actuarial survival rate: ten cases with wide surgical margin 87.5%o five cases with intralesional or marginal surgical margin 25%. Early surgical excision of chondrosarcoma with enough wide surgical margin can prevent local recurrence and metastasis.
Amputation ; Brain ; Chondrosarcoma ; Diagnosis ; Disarticulation ; Drug Therapy ; Female ; Fingers ; Follow-Up Studies ; Humans ; Humerus ; Korea ; Lung ; Lymphedema ; Male ; Natural History ; Necrosis ; Neoplasm Metastasis ; Orthopedics ; Pelvis ; Recurrence ; Ribs ; Spine ; Survival Rate

No abstract available.
Drainage* ; Pancreatic Pseudocyst*

No abstract available.
Histiocytoma, Malignant Fibrous*