1.Viability of calvarial bone grafts according to the contact surface.
Seong Geun PARK ; Joong Won SONG ; Ki Hwan HAN ; Jin Sung KANG ; Kwan Kyu PARK
Journal of the Korean Society of Plastic and Reconstructive Surgeons 1991;18(3):437-447
No abstract available.
Transplants*
2.The antitumor effect of various cytokines on human neuroblastoma cell lines SK-N-SH, IMR-32, and SK-N-MC.
Tae Sook HWANG ; Hyung Geun SONG ; Seong Hoe PARK ; Eui Keun HAM
Journal of the Korean Cancer Association 1992;24(1):35-46
No abstract available.
Cell Line*
;
Cytokines*
;
Humans*
;
Neuroblastoma*
3.Multidisciplinary Diagnostic Approach and Etiologic Evaluation of Patients with Developmental Disorders.
Ji Hyun YOON ; Jong Geun SONG ; Dong Ho SONG ; Young Key KIM ; Seong Woo KIM ; Hee Jung CHUNG
Journal of the Korean Child Neurology Society 2005;13(2):232-242
PURPOSE: The prevalence of developmental delay is 5-10% of the total pediatric population and early diagnosis and proper intervention are essential but a challenge for clinicians. We performed this study for several purposes. First is to know the distribution & characteristics of developmental disorders in Korea. Second is to identify all possible causes of these disorders through a multidisciplinary diagnostic approach, and thus to find out the clinical variables that are helpful in finding the etiology. And finally to develop a useful protocol that eliminates the cost of unnecessary tests and raises the diagnostic rate of the cause. METHODS: 518 patients(M 349, F 169) were studied who visited Ilsan Hospital Developmental Disorder Clinic(DDC) for the evaluation of developmental delay from April 2001 to Jan 2005. RESULTS: The mean age was 51.5+/-32.9 months, ranging from 2 months to 16.0 years of age with a majority of the preschool children(<6 yr)(79.3%). Phenomenological diagnosis consisted of 133 cases of mental retardation, 122 cases of autistic disorders, 101 cases of delayed language disorders, 27 cases of cerebral palsies, and 91 cases labeled as simple developmental delay requiring follow up due to age less than 2 years of age. Etiologic diagnosis was obtained in 119 cases(22.9%) out the 518 cases of developmental delays. 37 cases of chromosomal anomalies, 23 cases of Periventricular leukomalacia and hypoxic ischemic encephalopathy, 21 cases of syndromes, 7 cases of malformation of cortical development, 4 cases of myopathies, 4 cases of neuropathies, and 4 cases of cerebral infarctions were found. Among the clinical variables, low birth weight, facial dysmorphism, hypotonia, focal neurologic signs, and abnormalities in MRI, chromosome, EEG and EMG studies contributed to the yields of etiologic diagnosis significantly. CONCLUSION: Possible etiology was determined in about 23% of the subjects. The most important part of the assessment for the identification of etiology is thorough history taking, physical and neurologic examination. Neuroimaging study is useful in case of micro or macrocephaly, focal neurologic signs. Genetic studies increasingly produce a yield, when there is family history of inherited disorder and there are dysmorphic features. Routine metabolic screening test has limited utility. Development of a useful screening protocol adequate for Korean situation is required.
Cerebral Infarction
;
Diagnosis
;
Early Diagnosis
;
Electroencephalography
;
Follow-Up Studies
;
Humans
;
Hypoxia-Ischemia, Brain
;
Infant, Low Birth Weight
;
Infant, Newborn
;
Intellectual Disability
;
Korea
;
Language Disorders
;
Leukomalacia, Periventricular
;
Macrocephaly
;
Magnetic Resonance Imaging
;
Mass Screening
;
Muscle Hypotonia
;
Muscular Diseases
;
Neuroimaging
;
Neurologic Examination
;
Neurologic Manifestations
;
Paralysis
;
Prevalence
4.A Case of Malignant Lymphoma with Cardiac Involvement at Initial Presentation.
Geun Chan LEE ; Jae Geun CHO ; Sung Jun CHOI ; Jae Kwan SONG ; Jae Joong KIM ; Seong Wook PARK ; Seung Jung PARK ; Jong Koo LEE
Korean Circulation Journal 1994;24(6):899-903
Lymphomatous involvement of the heart, occurring at initial diagnosis and presentation, is extremely rare. We report here a case of 58 year old man who presented with generalized edema, pericardial effusion, and a large right atrial mass detected by transesophageal echocardiography. There is no other evidence of disseminated lymphoma in this patient. Tumor removal and pulmonary embolectomy was done. Pathologically, the mass was malignant lymphoma, diffuse large cell type. Unfortunately, we have no chance to perform the intensive chemotherapy. The patient discharged in moribund state.
Diagnosis
;
Drug Therapy
;
Echocardiography, Transesophageal
;
Edema
;
Embolectomy
;
Heart
;
Humans
;
Lymphoma*
;
Middle Aged
;
Pericardial Effusion
5.Macular Thickness Changes with Age in Normal Subjects Measured by Optical Coherence Tomography.
Jae Hoon KANG ; Sun A KIM ; Woo Geun SONG ; Hee Seong YOON
Journal of the Korean Ophthalmological Society 2004;45(4):592-598
PURPOSE: To evaluate the retinal thickness changes of the macula with age in normal subjects using optical coherence tomography. METHODS: Included were 56 patients with no systemic disease and no ophthalmoscopic evidence of retinopathy and who had a best corrected visual acuity of 1.0 or better. The measurement of the retinal thickness obtained by OCT III was analyzed using the computerized topographic mapping protocol (6 mm diameter map) according to age, refraction error, sex and macular region. We analyzed how they correlated to each other. RESULTS: The mean standard deviations of foveal thickness and retinal thickness within 1 mm diameter of the center were 182 +/- 26 micro meter and 208 +/- 18 micro meter in normal eyes, respectively. There was no statistically significant change with age (p>0.01). But the measurements at 3 and 6 mm from the fovea showed reduced retinal thickness with age (p<0.01). And the retinal thickness in the macular area did not correlate significantly with the refractive error nor with sex (p>0.01). There was a significant difference between the nasal quadrant and temporal quadrant within the 3 mm diameter of the center, and there was also a significant difference between the superior quadrant and inferior quadrant, and between the nasal quadrant and temporal quadrant within the 6 mm diameter of the center (p<0.01). CONCLUSIONS: Retinal thickness around the fovea as measured by OCT showed a decrease with age, although the fovea and the region within 1mm diameter of the center showed no statistical associations with age.
Humans
;
Refractive Errors
;
Retinaldehyde
;
Tomography, Optical Coherence*
;
Visual Acuity
6.LENGTHENING OF SHORT TUBULAR BONE IN HAND.
O Hyun HWANG ; Jun Sik KIM ; Jae Woo PARK ; Seong Geun PARK ; Young Hwan KIM ; Hae Rong SONG
Journal of the Korean Society of Plastic and Reconstructive Surgeons 1997;24(5):1100-1109
No abstract available.
Hand*
7.Case of Raynaud Syndrome after the Use of Methimazole.
Yunkyung KIM ; Hee Sang TAG ; Geun Tae KIM ; Seung Geun LEE ; Eun Kyung PARK ; Ji Heh PARK ; Seong min KWEON ; Song I YANG ; Jeong Hoon KIM
Journal of Rheumatic Diseases 2018;25(3):203-206
Raynaud syndrome is a medical condition that causes pain, numbness, and changes in skin color at the distal extremities. Raynaud syndrome can be subdivided into primary Raynaud's and secondary Raynaud's. The former is diagnosed when the cause is unknown and the latter is caused by an underlying condition, such as connective tissue diseases, injury, smoking, or certain medications. Both cancer chemotherapy and β-blockers are relatively common causes of Raynaud syndrome but there are no reports of its association with methimazole administration. The authors encountered a 43-year old woman with hyperthyroidism who developed digital ulcers associated with Raynaud syndrome after a methimazole treatment. Her digital ulcers and Raynaud syndrome were improved after methimazole was replaced with propylthiouracil and conventional therapy. This paper reports this case along with a review of the relevant literature.
Connective Tissue Diseases
;
Drug Therapy
;
Extremities
;
Female
;
Humans
;
Hyperthyroidism
;
Hypesthesia
;
Methimazole*
;
Propylthiouracil
;
Skin Pigmentation
;
Smoke
;
Smoking
;
Ulcer
8.Influence of radiation therapy on T lymphocyte and subsets in peripheral blood of various cancer patients.
Chang Geun JEONG ; Woo Song HA ; Soon Tae PARK ; Soon Chan HONG ; Ho Seong HAN ; Sang Beom KIM ; Kyu Young CHAE ; Ok Jae LEE
Journal of the Korean Surgical Society 1993;45(5):765-774
No abstract available.
Humans
;
Lymphocytes*
9.Comparison of 3 Phenotypic-detection Methods for Identifying Plasmid-mediated AmpC beta-lactamase-producing Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis Strains.
Wookeun LEE ; Bochan JUNG ; Seong Geun HONG ; Wonkeun SONG ; Seok Hoon JEONG ; Kyungwon LEE ; Hyo Sun KWAK
The Korean Journal of Laboratory Medicine 2009;29(5):448-454
BACKGROUND: Plasmid-mediated AmpC beta-lactamases (PABLs) have been detected in the strains of Escherichia coli, Klebsiella spp., Proteus mirabilis, and Salmonella spp. PABLs may be difficult to detect and might interfere in the therapeutic and infection-control processes. Although several PABL-detection methods based on phenotypes have been reported, the Clinical and Laboratory Standards Institute currently does not recommend a routine detection method for PABLs. The aim of this study is to compare the performances of 3 phenotypic PABL detection methods. METHODS: Total 276 non-duplicated clinical isolates of E. coli (N=97), K. pneumoniae (N=136), and P. mirabilis (N=43) were collected from 14 hospitals in Korea between April and June 2007 in a non-consecutive and non-random manner. Multiplex PCR was performed to detect the PABL genes. Further, 3 phenotypic detection methods-cephamycin-Hodge test, Tris-EDTA (TE) disk test, and combination-disk test with 3-aminophenylboronic acid (BA)-were performed using cefoxitin and cefotetan disks. RESULTS: PABL genes were detected by multiplex PCR in 122/276 isolates, including 14/97 E. coli, 105/136 K. pneumoniae, and 3/43 P. mirabilis isolates. The combination-disk test with BA showed higher sensitivity (98.4%), specificity (92.2%), and efficiency (96.3%) than the cephamycin-Hodge (76.2%, 96.1%, and 88.6%, respectively) and the TE-disk (80.3%, 91.6%, and 87.9%, respectively) tests. CONCLUSIONS: The combination-disk test with BA is a simple, efficient, and interpretable test that can be applicable in clinical laboratories involved in the detection of PABLs in clinical isolates of E. coli, K. pneumoniae, and P. mirabilis.
Anti-Bacterial Agents/pharmacology
;
Bacterial Proteins/*analysis
;
Cefotetan/pharmacology
;
Cefoxitin/pharmacology
;
Disk Diffusion Antimicrobial Tests/*methods
;
Escherichia coli/genetics/*isolation & purification
;
Humans
;
Klebsiella pneumoniae/genetics/*isolation & purification
;
Phenotype
;
Plasmids
;
Proteus mirabilis/genetics/*isolation & purification
;
Sensitivity and Specificity
;
beta-Lactamases/*analysis
10.Successful Management of Periampullary Diverticular Bleeding with Hemoclipping Using Side-viewing Endoscope during Endoscopic Retrograde Cholangiopancreatography.
Bo Geun PARK ; Young Wook YOO ; Joon Cheol SONG ; Sung Hee GAM ; Mi Sung KIM ; Byeong Seong KO
The Korean Journal of Gastroenterology 2016;67(3):146-149
Periampullary diverticulum is commonly found during endoscopy and can occur at any age although its prevalence increases with age. Periampullary diverticular bleeding is a rare and difficult to diagnose during clinical practice because of its unique appearance and location. This often can lead to massive bleeding and interfere with adequate bleeding control. Endoscopic management on duodenal diverticular bleeding is limited compared to colonic diverticular bleeding due to lack of experience. Herein, we report a case of active bleeding from a periampullary diverticulum during bile duct stone extraction diagnosed by side-viewing endoscope and successfully controlled using hemoclips without any complications.
Aged
;
Ampulla of Vater/surgery
;
Cholangiopancreatography, Endoscopic Retrograde
;
Diverticulum/*diagnosis/surgery
;
Gastrointestinal Hemorrhage/etiology/*therapy
;
Humans
;
Male
;
Surgical Instruments
;
Tomography, X-Ray Computed