No abstract available.
Abdominal Pain* ; Child* ; Gastritis* ; Helicobacter pylori* ; Helicobacter* ; Humans

A case of postirradiation extraskeletal osteosarcoma with aggressive fibromatosis of the overlying soft tissue of radiation field is reported in a 57 year old house wife who was treated with operation and radiation therapy for cervix carcinoma of the uterus 23 years ago. The overlying aggressive fibromatosis showed characteristic radiation angiitis and atrophic vascular changes such as hyaline degeneration and obliteration of the capillaries which were highly campatible with radiation changes. She also had multiple osteogenic sarcoma in pelvic cavity, occurring in the mesentery bed. As for the histogenesis in this case, we thought the possiblity that fibroblasts went through a process of differentiation into osteoblasts that were responsible for bone formation in the process of malignant change of the aggressive fibromatosis.

No abstract available.
Cisplatin* ; Hearing Loss* ; Hearing*

No abstract available.
Arthritis, Infectious* ; Hip Joint* ; Hip*

To study the biology of the endothelium and the media of the vascular wall, full layer vascular wall model was constructed in vitro. In the experimental vascular wall model, endothelial cell (EC)s were grown on a collagen lattice containing multilayers of smooth muscle cell (SMC)s and a EC-free portion was made by a cloning ring on the culture disc. As conditioned culture media of ECs-SMCs contain biologic mediators that may promote the growth of SMCs, the availability of this vascular wall model promptly us to examine the extent to which ECs regulate the migration and proliferation of SMCs when these cells are maintained with or without covering EC lining in coculture. Morphologic characteristics of full layer vascular wall model was a whitish, non-transparent membrane. Outer boundaries and the zone of no EC were thicker than that of central portion. By light microscope imaging, luminal surface was composed of EC monolayer, and SMCs and collagen fibers were distributed between the polyethylene terephtalate (PET) membrane and EC monolayer. SMCs and collagen fibers were mainly located near the PET membrane. Venous SMCs were densely infiltrated as compared to arterial SMCs. By scanning electron microscopy, EC monolayer and dense collagen fibers in the zone of no EC were clearly shown. On the effects of platelet derived growth factor (PDGF) in the proliferation of SMCs and modeling of full layer vascular wall model, no effect on SMC in the zone of EC covering was seen however, active migration and proliferation of SMCs were noted in the zone of no EC. Wall thickness was two times greater than that of control. On the effects of EGF, it was observed that EGF markedly stimulated migration of SMCs with or without EC coverings in contrast to the control group. On the effects of FGF, results were similar to the PDGF group. Results on the effect of IGF-1 were similar to the PDGF group. As conclusions, full layer vascular wall model in this study was proved to be a good laboratory model for basic vascular research. And SMCs migration and proliferation were more active in venous SMCs compared to arterial SMCs. The collagen fibers were also richer and the wall was more thickened. EGF was most the potent SMC stimulator. PDGF, FGF, and IGF-1 were moderate SMC stimulator in the zone of no EC covering. These results strongly support why intimal hyperplasia eventually occured in autogenous venous bypass graft.
Biology ; Clone Cells ; Cloning, Organism ; Coculture Techniques ; Collagen ; Culture Media, Conditioned ; Endothelial Cells ; Endothelium ; Epidermal Growth Factor ; Hyperplasia ; Insulin-Like Growth Factor I ; Membranes ; Microscopy, Electron, Scanning ; Muscle, Smooth ; Myocytes, Smooth Muscle ; Phenobarbital ; Platelet-Derived Growth Factor ; Polyethylene ; Transplants

Though the lung is the main site of infection with Paragonimus Westermani, during the migration periods of the larva, any place of the body including brain, orbit, liver, intestinal wall, diaphragm, subcutaneous tissues, and etc. may be infected with the larva. But the ectopic Paragonimus westermani in the scrotum is very rare instance. Recently, we found an ectopic Paragonimus westermani in the scrotum from 55 years old male patient who admitted to our hospital under the impression of scrotal mass. Although the histopathological findings bore some resemblance to the changes of the infection with tuberculosis, the definite clue in differentiation from tuberculosis was the discovery of the adult worm and eggs of the Paragonimus westermani in the lesions.
Adult ; Brain ; Diaphragm ; Eggs ; Humans ; Larva ; Liver ; Lung ; Male ; Middle Aged ; Orbit ; Ovum ; Paragonimus westermani* ; Paragonimus* ; Scrotum* ; Subcutaneous Tissue ; Tuberculosis

PURPOSE: End-stage ankle arthritis is frequently combined with ankle-hindfoot deformity or ankle instability and therefore additional surgical procedures are often required when performing total ankle arthroplasty. We report the short term clinical and radiographic results of the total ankle arthroplasty with/without the combined adjunctive surgical procedures. MATERIALS AND METHODS:The study is based on the 17 ankles (16 patients) of end-stage ankle arthritis that were treated with HINTEGRA(R)Total ankle prosthesis (Newdeal, Lyons, France) total ankle arthroplasty (TAA) from 2004 to 2007 with at least 12 months follow-up. The combined adjunctive procedures as well as the VAS pain score, AOFAS score, radiographic measurements and patient satisfactions were evaluated. RESULTS:Average follow-up period was 29 months (13~55 months) , and the age was average 62 years (39~75 years) old. Among total of 17 ankles, varus deformity and lateral ankle instability were found in 4 cases and 3 cases respectively. Twenty additional procedures such as Achilles triple hemisection (9), calcaneal displacement osteotomy (4) and lateral ankle ligament reconstruction (3) were performed in adjunct to TAA in 13 ankles. VAS pain score improved from preoperative average 8.4 (7~10) to 2.0 (0~5) and the AOFAS functional score improved from 41.8 points (13~71 points) to 90.6 (77~100 points) at final follow-up. Ninety-four percent of the patients were satisfied with the surgery. CONCLUSION: We confirmed that many adjunctive combined surgical procedures are often necessary in addressing the end-stage ankle arthritis (74%) with total ankle arthroplasty. We also achieved quite good clinical and radiographic short term results, although the long term follow-up study with larger number of cases are needed in the future.
Animals ; Ankle ; Arthritis ; Arthroplasty ; Congenital Abnormalities ; Displacement (Psychology) ; Follow-Up Studies ; Humans ; Ligaments ; Osteotomy ; Prostheses and Implants

PURPOSE: To evaluate the clinical outcome of proximal plantar fasciitis after nonoperative treatment, and also to find the correlation of the heel pain with the plantar fascia thickness measured by ultrasonography. MATERIALS AND METHODS: The study is based on 41 patients, 46 feet of the proximal plantar fasciitis that were treated conservatively with at least 12 months follow-up. All were treated with heel pad, Achilles and plantar fascia stretching and pain medications for at least 3 months. Heel ultrasonography was performed at the beginning of the treatment to measure the plantar fascia (PF) thickness and the echogenicity. PF thickness over 4 mm and less were grouped in to group A and B respectively to compare the clinical outcome. RESULTS: Average thickness of the PF at the calcaneal attach was 5.2 mm. Symptom duration before the treatment was average 13.2 month; group A being 14.6 months and group B being 9.0 months with no significant difference (p=0.09). As functional evaluation, Roles-Maudsley score improved from 3.4 initially to 2.3 at final follow-up, while morning heel pain also improved from average VAS pain score of 7.2 to 4.0. However Maudsley and VAS score both didn't show statistical difference between the 2 groups (p>0.05). CONCLUSION: Plantar fasciitis improved substantially with the nonoperative treatments. However, the 2 groups, divided according to 4 mm thickness by ultrasonography, didn't show significant difference in either symptom duration or in the clinical outcomes.
Fascia ; Fasciitis, Plantar ; Follow-Up Studies ; Foot ; Heel ; Humans

This study analyzed 88 patients who sustained a cervical spine injury during the past 4 years(Jan, 1993-May, 1996) in whom had 33 anterior, 21 posterior interventions were underwent and 34 remaining patients recieved conservative treatment with halovest. In 45 cases of upper cervical injuries, 16 operations were done. Among these, anterior approach was used in 3 patients and posterior approach in 13 patients. In 43 cases of lower cervical injuries, 39 operations were done. The anterior approach was used in 30 patients, posterior approach in 9 patients, and bilateral approached in remaing 4 cases. For patients with a predominent posterior ligamentous or osteoligamentous lesion, we selected anterior approach, when closed reduction was possible. Whenever the facet joint remained interlocked, a posterior approach was chosen. This report does not mentioned priority of anterior procedure at any case. Although clinical experience does not support the experimental data, we examined the reliability of anterior approach with use of internal fixation.
Humans ; Ligaments ; Spine* ; Zygapophyseal Joint

We managed a 27-year-old woman, who suffered from a type II odontoid fracture, with a halo-vest. After 12 weeks, we confirmed bony fusion on cervical spine CT and managed her with a neck collar. During the OPD follow up, we checked the cervical spine film every 1 month. After two and half months, displaced odontoid process was noted on routine cervical film, and a bony gap was found at the previous fracture wite on cervical spine CT. There is only one report in the literlature describing a nonunion after radiographically confirmed healing of a type II odontoid fracture. We report this case in order to emphasize the importance of scheduled follow up examination and evaluate precipitating factors of delayed nonunion of odontoid fracture.
Adult ; Female ; Follow-Up Studies ; Humans ; Neck ; Odontoid Process ; Precipitating Factors ; Spine