Background and Objectives: Previous studies reported abnormalities in MRI as a poor prognostic indicator of sudden sensorineural hearing loss (SSNHL). Since abnormalities in three-dimensional (3D) fluid-attenuated inversion recovery (FLAIR) are strongly correlated with the initial hearing function, the prognostic value of the 3D FLAIR images should be carefully evaluated to avoid collinearity. We aimed to evaluate abnormalities on the 3D FLAIR images as an independent prognostic factor in the matched SSNHL groups.Subjects and Method We retrospectively reviewed medical records of 179 patients with SSNHL who underwent temporal MRI, including the 3D FLAIR sequence, between January 2015 and December 2019. Patients were divided based on the presence of cochlear abnormalities on the 3D FLAIR images. Hearing prognosis was evaluated with and without matching for initial hearing and treatment interval. Results: The groups were similar in sex (p=0.091), age (p=0.925), treatment interval (p= 0.216), and MRI interval (p=0.828). Notably, patients with cochlear abnormalities on the 3D FLAIR images showed distinctly more severe hearing loss (p<0.001) at the initial pure tone average (PTA) assessment and poorer outcomes (p<0.001) compared to those without abnormality. After matching for initial hearing and treatment interval, the hearing outcome, measured by PTA, was similar between the groups (p=0.681). Conclusion Cochlear signal abnormality in 3D FLAIR MRI was associated with poor initial hearing. However, it did not affect hearing recovery outcomes when the groups were matched.

Purpose: Septoturbinoplasty is frequently performed to correct nasal obstruction; however, there is still a lack of research on changes in nasal and nose-related symptoms early after septoturbinoplasty. Therefore, we aimed to investigate changes in subjective outcomes within 6 months after septoturbinoplasty. Materials and Methods: The medical records of patients who underwent septoturbinoplasty at Gangnam Severance Hospital were retrospectively analyzed. Symptom scores were evaluated using the Sino-nasal Outcome Test (SNOT-22) and obstruction scores.The SNOT-22 and obstruction scores were investigated before surgery and at 1, 3, and 6 months after surgery. Results: We noted significant decreases in both SNOT-22 and obstruction scores at 1 month after surgery, compared to those before surgery (p<0.001). However, there were no significant changes at 3 and 6 months after surgery, compared to scores at 1 month after surgery. Using multivariate logistic regression analysis, a larger difference between SNOT-22 scores preoperatively and 1 month after surgery was significantly associated with a significant improvement in symptoms at 3 or 6 months after septoturbinoplasty (p=0.029). Conclusion These results imply that subjective outcomes and degree of improvement in the first month after septoturbinoplasty can be used as a predictor of the results thereof and for counseling patients about its progress.

Carcinoma of Gall bladder remains a terminal illness in most patients despite improved diagnostic capabilities, better perioperative care and a more aggresive surgical approch based on improved knowledge of this tumors natural histiory. Overall 5-year survival rates remain below 5%. This failure to significantly improve patient oucome is largely due to late recognition of gall badder cancer. Authors experienced 21 cases of gall bladder cancer confirmed by operation at the Kwang Ju Christian hospital from march 1983 to March 1991, and the results obtained were summarized as follows. (continue...)
Gallbladder Neoplasms ; Gwangju ; Humans ; Perioperative Care ; Survival Rate ; Urinary Bladder*

Malignant Leydig cell tumor of the testis is a very rare condition. A case of the malignant Leydig cell tumor arised from the right testis of seventy-year-old man is reported. The patient presented painless, 4 x 8 x 5 cm sized, mass without endocrinological manifestations and the mass was removed and diagnosed as a malignant Leydig cell tumor histologically showing frequent mitosis, pleomorphic cells in trabecular pattern with nuclear atypia, clear cells with foamy cytoplasm, and vascular invasion of tumor emboli in tumor capsule. No Reinke`s crystalloid was seen. The patient is now being followed in disease free state.
Cytoplasm ; Humans ; Leydig Cell Tumor* ; Mitosis ; Testis

Hemangiopericytoma is uncommon vascular neoplasm that arises from pericytes arround the capillary walls. It was first described as a distinct vascular neoplasm by Stout and Murray in 1942 The anatomic distribution is widespread throughout the body, with approximately one third occur in the head and neck. No sex predilection has been found. Although middle age appears to be the most prevalent time of onset, this neoplasm has been found in all age groups. The differentiation between benign and malignant hemangiopericytoma can be difficult. Although the majority of these tumors are benign, there are malignant variants that can metastasize. Metastasis of seemingly benign tumors may appear year of decade later, so long term close follow-up is needed The treatment of choice is complete surgical excision of the tumor. Despite their vascular origin, these tumors are relatively radioresistant. Radiation therapy is reserved for inoperable metastases or treatment of postoperative surgical fields. Here we present a case of hemangiopericytoma occuring on the Lt. buccal mucosa.
Capillaries ; Follow-Up Studies ; Head ; Hemangiopericytoma* ; Humans ; Middle Aged ; Mouth Mucosa* ; Neck ; Neoplasm Metastasis ; Pericytes ; Vascular Neoplasms

No abstract available.
Carcinogenesis ; DNA, Complementary ; Gene Expression Profiling ; Gene Expression ; Humans ; Oligonucleotide Array Sequence Analysis ; Salivary Glands

PURPOSE: This study was performed to investigate the clinical features of neuroendocrine lung cancer. MATERIALS AND METHODS: We performed a retrospective review of the histopathology and clinical information of 21 patients diagnosed as having neuroendocrine lung cancer between 1995 and 1999. RESULTS: Nineteen cases were male and 2 were female. The median age was 64 years (range: 45~80). Pathologic classification were atypical carcinoid (AC) in 2 cases, large cell neuroendocrine carcinoma (LCNEC) in 7 cases, and intermediate cell neuroendocrine carcinoma (ICNC) in 12 cases. Nine patients received tumor resection as first line therapy; adjuvant chemotherapy was given to 3 patients. Concurrent chemoradiotherapy was given to 1 patient. Six patients received palliative chemotherapy. The chemotherapy regimen included etoposide cisplatin in 5 cases and vinorelbine+cisplatin in 1 case. The median survival times were 11, 16 and 59 weeks for AC, LCNEC and ICNC, respectively. The estimated 2-year survival rates were AC 0%, LCNEC 22% and ICNC 31%. CONCLUSION: Surgery may have a positive effect on survival in patients with early stage cansers. Further investigation is required to improve survival in cases of advanced stage cancer.
Carcinoid Tumor ; Carcinoma, Neuroendocrine ; Chemoradiotherapy ; Chemotherapy, Adjuvant ; Cisplatin ; Classification ; Drug Therapy ; Etoposide ; Female ; Humans ; Lung Neoplasms* ; Lung* ; Male ; Retrospective Studies ; Survival Rate

PURPOSE: Eventhough cadaveric renal grafts are increasing, kidneys from living donors remain as the major mode of renal transplantations and there is a need to establish theoretical bases for securing the safety of the donors. Follow-up of donors was done for a year using several indices of renal function to evaluate the function of the remaining kidneys after donor nephrectomies. MATERIALS AND METHODS: Two hundred and sixty one living donors were included in this study. Blood urea nitrogen(BUN), serum creatinine, 24 hour creatinine clearance, 24 hour urine protein, and blood pressure were checked preoperatively. The same indices were checked at one, six, and twelve months after the operation. These indices were compared with those before the operation. RESULTS: Although some increase was observed in serum BUN, creatinine, and 24hr urine protein, and decrease in creatinine clearance after donor nephrectomies, all were within normal limits, which did not show clinically significant differences. All indices did not deviate from the normal limits through-out one year. CONCLUSIONS: Renal indices varied within normal limits and donor nephrectomies seemed to cause no significant harmful effect on the donors. Prospective and long term follow-up of the donors after donor nephrectomies are needed to ensure a high quality life of living donors.
Blood Pressure ; Cadaver ; Creatinine ; Follow-Up Studies* ; Humans ; Kidney ; Kidney Transplantation ; Living Donors ; Nephrectomy* ; Tissue Donors* ; Transplants ; Urea

Encephalitozoon cuniculi is a microsporidian parasite commonly found in rabbits that can infect humans, causing encephalitozoonosis. The prevalence of encephalitozoonosis is not well documented, even when many clinics suspect pet rabbits as being highly infected. This study investigated the seropositivity of E. cuniculi using ELISA. The examination of 186 rabbits using ELISA showed that 22.6% (42/186) were seropositive against E. cuniculi. In analysis with healthy status, all 42 seropositive sera were collected from clinically normal rabbits. Moreover, the gender and age of pet rabbits did not have anysignificant effect on E. cuniculi infection. To the best of our knowledge, this is the first report to describe the seroprevalence of E. cuniculi in pet rabbits and suggests that pet rabbits could act as an important reservoir of encephalitozoonosis for both pet animals and humans in Korea.
Animals ; Antibodies, Fungal/*blood ; Encephalitozoon cuniculi/*immunology ; Encephalitozoonosis/epidemiology/*veterinary ; Enzyme-Linked Immunosorbent Assay ; Female ; Korea/epidemiology ; Male ; *Pets ; Rabbits ; Seroepidemiologic Studies