Henoch-Schonlein Purpura (HSP) is a systemic vasculitis involving small vessels with the deposition of immune complexes containing IgA and C3, which is characterized by associated skin, joint, renal, and gastrointestinal manifestations. Although there were several causes such as autoimmunity, infection, and drugs, it also can be presented as a form of vasculitidies associated with malignancies. We report a case of HSP developed during treatment for non-small cell lung cancer in a 66-year-old man. Multiple purpuric skin lesions occurred in both legs after the first cycle of chemotherapy, which was diagnosed as HSP by clinical and pathologic examinations. Due to the itching sensation, topical steroid was applied and the patient was improved 3 weeks later without a scheduled change in chemotherapy.
Aged ; Antigen-Antibody Complex ; Autoimmunity ; Carcinoma, Non-Small-Cell Lung ; Humans ; Immunoglobulin A ; Joints ; Leg ; Lung ; Lung Neoplasms ; Pruritus ; Purpura, Schoenlein-Henoch ; Sensation ; Skin ; Systemic Vasculitis ; Vasculitis