1.The Analysis of Methylenetetrahydrofolate Reductase Mutation in Recurrent Spontaneous Abortion.
Yoon Sung NAM ; Kwang Yul CHA ; Nam Keun KIM ; Sun Hee KIM ; Jin Woo LIM ; Geum Duk KANG ; Myung Seo KANG ; Se Hyun KIM ; Doyeun OH
Korean Journal of Fertility and Sterility 2001;28(3):247-
OBJECTIVE: To analyze the methylenetetrahydrofolate reductase (MTHFR) mutation in patients with recurrent spontaneous abortion. MATERIAL AND METHOD: The blood samples of patients with recurrent spontaneous abortion were tested by PCR-RFLP method. RESULTS: Of 51 cases of study group, 14 (27.5%) were normal, 25 (49.0%) were heterozygosity, and 12 (23.5%) were homozygosity. Of 58 cases of control group, 20 (34.5%) were normal, 30 (51.7%) were heterozygosity, and 8 (13.8%) were homozygosity. But the difference between two groups was not significant (p=0.190). CONCLUSION: Hyperhomocysteinemia due to MTHFR mutation is a cause of recurrent spontaneous abortion. Therefore, the study for MTHFR mutation should be included in the workup of recurrent spontaneous abortion.
Abortion, Spontaneous*
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Female
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Humans
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Hyperhomocysteinemia
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Methylenetetrahydrofolate Reductase (NADPH2)*
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Pregnancy
2.Prognostic Factors of Necrotizing Enterocolitis.
Dong Won KANG ; Geum Hee GWAK ; Keun Ho YANG ; Byung Noe BAE ; Ki Hwan KIM ; Se Whan HAN ; Hong Joo KIM ; Young Duk KIM ; Myeung Jae CHOI
Journal of the Korean Association of Pediatric Surgeons 2008;14(2):144-152
Necrotizing enterocolitis (NEC) is the most common gastrointestinal emergency in the neonatal population. The aim of this study is to evaluate surgical indication and prognostic factors of NEC. Clinical data of seventy patients, diagnosed as NEC between January 2000 & January 2007, were reviewed retrospectively. Fifty-seven patients had medical treatment and 7 of them died. Thirteen patients who presented with pneumoperitoneum on plain abdominal film or were refractory to medical treatment received surgical treatment, and 5 of them died. All the expired 12 patients weighed less than 2500g. Twenty out of seventy patients showed thrombocytopenia, and 11 patients of them died. The finding of pneumoperitoneum and thrombocytopenia could be the most important surgical indication. Prematurity, low birth weight and thrombocytopenia were related to a bad prognosis. NEC patients who presents with these findings must be considered for close observation and intensive care.
Emergencies
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Enterocolitis, Necrotizing
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Humans
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Infant, Low Birth Weight
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Infant, Newborn
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Pneumoperitoneum
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Prognosis
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Retrospective Studies
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Thrombocytopenia