Objective To study the effects of family integrated care ( FIcare ) in the neonatal intensive care unit ( NICU) on preterm infants and their mothers′physical and mental health.Method From Jan 2016 to Dec 2016, preterm infants(birth weight 1000~2000 g;gestational age 26~34 weeks stabilized in NICU were randomly assigned into two groups:FIcare group and control group .The incidences of major diseases in infants , their mothers′depression score and anxiety score were studied .Result A total of 40 infants were assigned into two groups respectively .No significant differences existed between the two groups in gender , gestational age , brith weight , age, breastfeeding rate and their mothers′depression score and anxiety score (P>0.05).At discharge, the breastfeeding rate (90.0%vs.52.5%) and weight gain [(2258 ±112) g vs.(2105 ±103) g] of the FIcare group were significantly higher than the control group, and the hospital stay duration [(42.0 ±15.7) d vs.(43.5 ±14.3) d], hospitalization expenses [(40,000 ±18,000) RMB vs.(44,000 ±19,000) RMB], oxygen therapy duration [(10.4 ±5.7) d vs. (11.7 ±7.9) d], CPAP duration [(7.2 ±4.3) d vs.(8.1 ±5.0) d], mothers′depression score [(48.7 ±3.0) vs.(57.6 ±2.7)] and anxiety score [(49.4 ±1.1) vs.(61.1 ±1.9)]of the FIcare group were significantly lower than the control group ( P <0.05 ) . Conclusion Family-integrated care is beneficial for the recovery of preterm infants and their mother′s physical and mental health .