PURPOSE: Rehabilitation of the incomplete dentition by means of osseointegrated dental implants represents a highly predictable and widespread therapy; however, little is known about potential risk factors that may impair long-term implant success. METHODS: From 2004 to 2012, a total of 13,147 implants were placed in 4,316 patients at the Academy for Oral Implantology in Vienna. The survival rates after 8 years of follow-up were computed using the Kaplan-Meier method, and the impact of patient- and implant-related risk factors was assessed. RESULTS: Overall implant survival was 97% and was not associated with implant length (P=0.930), implant diameter (P=0.704), jaw location (P=0.545), implant position (P=0.450), local bone quality (P=0.398), previous bone augmentation surgery (P=0.617), or patient-related factors including osteoporosis (P=0.661), age (P=0.575), or diabetes mellitus (P=0.928). However, smoking increased the risk of implant failure by 3 folds (P<0.001) and a positive history of periodontal disease doubled the failure risk (P=0.001). CONCLUSIONS: Summing up the long-term results of well over 10,000 implants at the Academy for Oral Implantology in Vienna it can be concluded that there is only a limited number of patients that do not qualify for implant therapy and may thus not benefit from improved quality of life associated with fixed implant-retained prostheses.
Dental Implantation, Endosseous ; Dental Implants ; Dental Prosthesis, Implant-Supported ; Dentition ; Diabetes Mellitus ; Follow-Up Studies* ; Humans ; Jaw ; Osteoporosis ; Periodontal Diseases ; Prostheses and Implants ; Quality of Life ; Rehabilitation ; Risk Factors* ; Smoke ; Smoking ; Survival Analysis ; Survival Rate

OBJECTIVETo evaluate the reliability of Bio-Oss particles as bone grafts in combination with membrane-technique.

METHODS6 small biopsy specimens were retrieved without causing iatrogenic damage in 6 patients (implant sites). The Donath's hard tissue section and micro grinding technique was adopted, and Leval Laczko staining method was used.

RESULTSThe histological results showed Bio-Oss particles were easily distinguished from the newly formed bone, but new bone was formed among different particles of Bio-Oss, no connective tissue was found. Intimate contact between newly formed bone and particles of the graft was present.

CONCLUSIONSBio-Oss appears to be highly biocompatible and osteoconductive. It can be used success fully as a bone substitute in combination with guided bone regeneration membrane technique.

Adult ; Bone Regeneration ; drug effects ; Bone Substitutes ; therapeutic use ; Bone Transplantation ; Female ; Guided Tissue Regeneration ; methods ; Humans ; Male ; Membranes, Artificial ; Middle Aged ; Minerals ; therapeutic use ; Oral Surgical Procedures ; methods ; Reproducibility of Results ; Time Factors