BACKGROUND: Granisetron, a new 5-HT3 receptor antagonist, was reported as a highly effective antiemetics, especially in combination with dexamethasone, in the prevention of acute emesis induced by cisplatin. But there is lack of data about effectiveness in the prevention of delayed emesis. In this study, the efficacy of granisetron plus dexamethasone in the prevention of delayed emesis induced by cisplatin was evaluated. MATERIALS AND METHODS: Sixty-four patients who were to receive high-dose cisplatin containing chemotherapy regimen were enrolled in this study. They were received 20 mg of dexamethasone and 3 mg of granisetron at 30 min and 10 minutes prior to cisplatin infusion, respectively. They were monitored for 5 days, first 24 hours for acute nausea/ vomiting and the subsequent 4 days for delayed nausea/vomiting. Antiemetic effect of granisetron was evaluated according to the criteria of Italian Group of Antiemetic Research. RESULTS: Control of delayed nausea and vomiting was achieved in 58% and 84%, respectively. Eastern Cooperative Oncology Group performance status was a statistically significant prognostic factor for control of acute vomiting and delayed nausea/vomiting. There were no stastically significant differences between control of delayed nausea/ vomiting and other prognostic factors, including sex, age, and prior history of cisplatin therapy. The antiemetic effect was greater in the patients who had controled acute nausea/ vomiting than those who had not. CONCLUSION: Granisetron plus dexamethasone is an excellent regimen in the control of not only acute emesis but also delayed emesis induced by high-dose cisplatin chemotherapy.
Antiemetics ; Cisplatin ; Dexamethasone* ; Drug Therapy ; Granisetron* ; Humans ; Nausea* ; Receptors, Serotonin, 5-HT3 ; Serotonin ; Vomiting*

BACKGROUND: The purpose of this study is to assess the prevalence of falls and to correlate if the fear of falling results in avoidance of activities in a rural community elderly population. METHODS: A cross-sectional study was done in 299 rural residents in Korea aged >60 years, between June 19, 2007 and June 21, 2007. Questionnaires about basic demographics, falling events, fear of falling (K-ABC), and limitations of daily activities (K-IADL) were completed. RESULTS: Among the 299 participants, 26.1% had experienced a fall. 197 participants confirmed that they experienced fear of falling (66.9%). This was further broken down to participants who were 'a little concerned'(31.4%), 'much concerned' (20.7%), and 'very much concerned' (13.7%). 183 people (61.2%) had limited daily activities caused by a fear of falling. Fallers experienced higher levels of anxiety and fear of falling than non-fallers (p<0.001). Comparing fear of falling with limited daily activities shows that the greater the fear of falling, the larger the limitation in daily activities and the lower the K-IADL score. After adjusting for falling, multiple linear regression showed that fear of falling and limited daily activities were positively correlated (p<0.001). Among groups with fear of falling, non-fallers, exercise group (p=0.024), and good perceived health group (p=0.022) had no limitations in activities compared with the control groups. CONCLUSION: Modifying drinking habits, diet habits, and social activities associated with perceived health states may improve daily activity levels in the elderly residing in rural communities, even though they have the fear of falling.
Aged ; Anxiety ; Cross-Sectional Studies ; Demography ; Drinking ; Food Habits ; Humans ; Korea ; Linear Models ; Prevalence ; Surveys and Questionnaires ; Rural Population